Directors

Moody

David E. Moody, Ph.D.

Director, Center for Human Toxicology

Research Professor, Department of Pharmacology and Toxicology

Dr. Moody has long been involved in developing gas chromatographic or liquid chromatographic mass spectrometric techniques to detect and quantitate drugs, drug metabolites and endogenous small organic molecules in biological specimens.  He has used these techniques to perform personal research on the in vitro and in vivo metabolism of select opioids in humans.  Dr. Moody has also used these techniques to collaborate with other investigators for studies that explore drug action and drug safety.  He is always open to conversations with colleagues about potential collaborative projects that employ these analytical skills.  Dr. Moody also provides consultative advice on interpretation of physiological drug concentrations in forensic cases.


Wilkins

Diana G. Wilkins, Ph.D.

Associate Director, Center for Human Toxicology

Professor, Department of Pathology
Adjunct Professor, Department of Pharmacology and Toxicology

Dr. Wilkins has been actively engaged in numerous research and scholarly activities while at the University of Utah. Her current research interests include investigation of the disposition of selected environmental toxicants in biological matrices, mechanisms underlying the formation of protein adduct biomarkers of acetaminophen toxicity, pharmacokinetic studies of therapeutic drugs in pediatric populations, and general applications of mass spectrometry in biomedical research. While maintaining an active research and service program, Dr. Wilkins directs and participates in teaching both undergraduate and graduate courses in laboratory management, clinical and analytical toxicology, pharmacology and statistics at the University of Utah. Dr. Wilkins strongly believes in to creating a classroom and laboratory learning climate where both undergraduate and graduate students at any level of a program become increasingly comfortable with expressing their ideas, taking risks in forming independent opinions, and communicating those beliefs to others. In the context of learning at the University of Utah, she believes that students learn best when placed in a classroom and laboratory environment that provides a strong foundation of knowledge in the discipline, as well as practical experience in the application of those principles into practice.


Reilly

Christopher A. Reilly, Ph.D.

Associate Director, Center for Human Toxicology

Adjunct Associate Professor, Department of Anesthesiology
Associate Professor, Department of Pharmacology and Toxicology

Dr. Reilly is broadly interested in understanding the mechanistic basis of drug action in humans. Dr. Reilly has an active translational research program that utilizes a broad range of technologies that permit the development and application of diverse assays to study mechanism of xenobiotic action and metabolic clearance of xenobiotics from biological systems. Dr. Reilly’s specialties are in cell and animal models of human pathologies and conditions, genetic manipulation and analysis, mass spectrometry, and various aspects of drug metabolism, including reaction phenotyping, structural identification, and pharmacokinetics support. Dr. Reilly and staff are highly collaborative and welcome opportunities to work with collaborators on a multitude of research projects.


Douglas E. Rollins, M.D., Ph.D.

Director Emeritus, Center for Human Toxicology

Professor Emeritus, Department of Pharmacology and Toxicology



Moody

David M. Andrenyak, Ph.D., DABFT

Assistant Director and Research Toxicologist, Center for Human Toxicology

Bachelor of Science - Forensic Science, University of New Haven, 1978

Doctor of Philosophy - Pharmacology, University of Connecticut Health Center, 1984

Diplomate American Board of Forensic Toxicology, 1991

Dr. David M. Andrenyak is an Assistant Director and Research Toxicologist within the Center for Human Toxicology. He has been involved for over 25 years in the analysis for drugs, poisons, and metabolites in samples submitted to the lab. Most of this effort uses gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry, but expertise in other analytical techniques has been employed as needed. His work also involves analytical method development, data review, and interpretation of data. Dr. Andrenyak is Board Certified in Forensic Toxicology. He welcomes opportunities to review and comment on medico-legal cases involving forensic toxicology; he will also receive selected analytical forensic toxicology case work if it is within the realm of expertise at the Center.

Selected References (Dr. Andrenyak)

Slawson, M.H., Crouch,  D.J.,  Andrenyak, D.,  Rollins,  D.E.,   Lu, J. K.,  Bailey, P.L. Determination of Morphine,  Morphine-3-Glucuronide, and Morphine-6-Glucuronide in Plasma after Intravenous and  Intrathecal Morphine Administration  Using HPLC with Electrospray Ionization and Tandem Mass Spectrometry.  Journal of Analytical Toxicology.  23: 468-473  (1999). 

Huang, W., Moody, D.E., Andrenyak, D.M.,  Smith, E.K.,  Foltz, R.L., Huestis, M.A., Newton, J.F. Simultaneous Determination of ∆9-Tetrahydrocannabinol and 11-nor-∆9-Tetrahydrocannabinol in Human plasma by Solid-Phase Extraction and Gas Chromatography-negative Ion Chemical Ionization -Mass Spectrometry. Journal of Analytical Toxicology  25:531-537 (2001).

Moody, D.E, Fang, W.B., Andrenyak, D.M., Jones, C.  2006.  A Comparative Evaluation of the Instant-View 5-Panel Test Card with On Trak Testcup Pro 5: Comparison with Gas Chromatography-Mass Spectrometry.  Journal of Analytical Toxicology.  30: 50-56 (2006).

Hadlock, G.C., Webb, K.M.,  McFadden, L.M.,  Chu, P.W.,  Ellis, J.D.,  Allen, S.C.,  Andrenyak, D.M.,  Vieira-Block, P.L.,  German, C.L.,  Conrad, K.M.,   Hoonakker, A.J.,  Gibb, J.W.,  Wilkins, D.G.,  Hansen, G.R.,  and Fleckenstein, A.E.  4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse.  Journal of Pharmacology and Experimental Therapeutics.   339:530-536  (2012)

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