Members

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Principle Investigator

 

Jindrich (Henry) Kopecek

Distinguished Professor of Pharmaceutics and Pharmaceutical Chemistry, and of Bioengineering

Henry’s research interests are focused on biorecognition of macromolecules, bioconjugate chemistry, drug delivery systems, and self-assembly of hybrid macromolecules. Henry and his coworkers focused on the synthesis, stimuli sensitivity, biocompatibility and clinical applications of hydrogels (reviewed in J. Polym. Sci. Part A: Polym. Chem. 47, 5929, 2009), followed by the design and development of backbone degradable N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers as anticancer drug carriers (reviewed in J. Controlled Release 190, 288, 2014). Recently the focus is on self-assembly of hydrogels from block or graft copolymers mediated by coiled-coil and beta-sheet protein domains (see Biomacromolecules 7, 1187, 2006; Ang. Chem. Int. Ed. 51, 7396, 2012) and the design of a new paradigm in polymer therapeutics – drug-free macromolecular therapeutics (reviewed in Biomaterials Sci. 3, 908, 2015). Kopecek CV

     

    Research Professors

     

    Jiyuan (Jane) Yang

    Research Professor

    Jane, received her B.S. in Chemical Engineering from Tsinghua University, Beijing in 1986, M.S. in Polymer Materials from Dalian Technical University in 1989, and Ph.D. in Biomedical Polymer Science from Peking University in 2001. She joined our lab in 2003 following a postdoctoral fellowship at the Department of Physical Chemistry, Institute Curie in Paris, France. Jane’s research focuses on hydrogels formed by self-assembly of graft copolymers mediated by coiled-coil domains, as well as design and synthesis of backbone degradable N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-anticancer drug conjugates.

      Postdoctoral Fellows

       

        Lian Li

        Lian received his B.S. and Ph.D. in pharmaceutics at Sichuan University, China in 2012 and 2016, respectively. His research will focus on drug-free macromolecular therapeutics and relationship between the structure of HPMA copolymer-anticancer drug conjugates and their biological properties.

            Libin Zhang

            Libin received his B.S. in applied chemistry and biotechnology, respectively, at Jilin University in 2007. He received his Ph.D. in organic chemistry from Institute of Chemistry the Chinese Academy of Sciences, Beijing, China in 2012. Libin joined our lab at the beginning of 2015 following a postdoctoral fellowship at the Department of Biomedical Engineering, School of Medicine, Tsinghua University (Beijing, China). His research focuses on the protein-polymer conjugates and antibody-polymer drug conjugates.

               

              Graduate Students

               

              Chris Radford

              Chris is a Ph.D. student in the Department of Bioengineering. He received his B.S. degree in Biomedical Engineering from Duke University. His research focuses on the in vivo fate of backbone degradable polymer carriers of anticancer drugs using the FRET technique.

                Jiawei Wang

                Jiawei is Ph.D. student in the Department of Pharmaceutics and Pharmaceutical Chemistry. She received a B.S. degree in Biological Sciences from the East China University of Science and Technology in Shanghai in 2012 and a M.S. degree in Pharmaceutical Sciences from the University of Southern California in Los Angeles in 2014. After rotating through four laboratories during her year as a student in the Biological chemistry program, she joined our laboratory to study drug-free macromolecular therapeutics.

                   

                  Staff

                   

                  Leigh Ann Bauman

                  Leigh Ann is our Project Coordinator. She coordinates research in our lab, orders supplies, helps to prepare new grant applications and grant progress reports, as well as publication records. In addition, she takes care of financial management reports.

                     

                    Professor Emeriti

                     

                    Pavla Kopeckova

                    Pavla retired in March 2011. She was appointed Research Professor Emerita. She is still involved in Kopecek group research life, attending group meetings, reviewing reports, proposals, and manuscripts.

                       

                      Senior and Visiting Scientists/Students

                       

                        Yixin Fang

                        Dr. Fang obtained her Ph.D. in Organic Chemistry from the Institute of Chinese Chemistry, Chinese Academy of Sciences, Beijing, China in 2015. As a visiting scholar, her research focuses on the design, synthesis and evaluation of endosomolytic polymers.

                            Susumu Hama

                            Dr. Hama is a visiting professor in our lab from Kyoto Pharmaceutical University, Kyoto, Japan.

                               

                              Undergraduate Students

                               

                                Mai Doan

                                Mai is an undergraduate student in the Department of Bioengineering.  She studies targeted HPMA copolymer conjugates for drug delivery applications.

                                    Christian Kodele

                                    Christian is an undergraduate student in the Department of Bioengineering. His research is on drug-free macromolecular therapeutics.