Jindrich (Henry) Kopecek
Distinguished Professor of Pharmaceutics and Pharmaceutical Chemistry, and of Bioengineering
Henry’s research interests are focused on biorecognition of macromolecules, bioconjugate chemistry, drug delivery systems, and self-assembly of hybrid macromolecules. Henry and his coworkers focused on the synthesis, stimuli sensitivity, biocompatibility and clinical applications of hydrogels (reviewed in J. Polym. Sci. Part A: Polym. Chem. 47, 5929, 2009), followed by the design and development of backbone degradable N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers as anticancer drug carriers (reviewed in J. Controlled Release 190, 288, 2014). Recently the focus is on self-assembly of hydrogels from block or graft copolymers mediated by coiled-coil and beta-sheet protein domains (see Biomacromolecules 7, 1187, 2006; Ang. Chem. Int. Ed. 51, 7396, 2012) and the design of a new paradigm in polymer therapeutics – drug-free macromolecular therapeutics (reviewed in Biomaterials Sci. 3, 908, 2015). Kopecek CV
Jiyuan (Jane) Yang
Jane, received her B.S. in Chemical Engineering from Tsinghua University, Beijing in 1986, M.S. in Polymer Materials from Dalian Technical University in 1989, and Ph.D. in Biomedical Polymer Science from Peking University in 2001. She joined our lab in 2003 following a postdoctoral fellowship at the Department of Physical Chemistry, Institute Curie in Paris, France. Jane’s research focuses on hydrogels formed by self-assembly of graft copolymers mediated by coiled-coil domains, as well as design and synthesis of backbone degradable N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-anticancer drug conjugates.
Lian received his B.S. and Ph.D. in pharmaceutics at Sichuan University, China in 2012 and 2016, respectively. His research will focus on drug-free macromolecular therapeutics and relationship between the structure of HPMA copolymer-anticancer drug conjugates and their biological properties.
Libin received his B.S. in applied chemistry and biotechnology, respectively, at Jilin University in 2007. He received his Ph.D. in organic chemistry from Institute of Chemistry the Chinese Academy of Sciences, Beijing, China in 2012. Libin joined our lab at the beginning of 2015 following a postdoctoral fellowship at the Department of Biomedical Engineering, School of Medicine, Tsinghua University (Beijing, China). His research focuses on the protein-polymer conjugates and antibody-polymer drug conjugates.
Chris is a Ph.D. student in the Department of Bioengineering. He received his B.S. degree in Biomedical Engineering from Duke University. His research focuses on the in vivo fate of backbone degradable polymer carriers of anticancer drugs using the FRET technique.
Jiawei is Ph.D. student in the Department of Pharmaceutics and Pharmaceutical Chemistry. She received a B.S. degree in Biological Sciences from the East China University of Science and Technology in Shanghai in 2012 and a M.S. degree in Pharmaceutical Sciences from the University of Southern California in Los Angeles in 2014. After rotating through four laboratories during her year as a student in the Biological chemistry program, she joined our laboratory to study drug-free macromolecular therapeutics.
Senior and Visiting Scientists/Students
Dr. Fang obtained her Ph.D. in Organic Chemistry from the Institute of Chinese Chemistry, Chinese Academy of Sciences, Beijing, China in 2015. As a visiting scholar, her research focuses on the design, synthesis and evaluation of endosomolytic polymers.
Mai is an undergraduate student in the Department of Bioengineering. She studies targeted HPMA copolymer conjugates for drug delivery applications.