You Han Bae

Title: Professor

Contact Information:

University of Utah
College of Pharmacy
421 Wakara Way, #315
Salt Lake City, UT 84108
PHONE: 801-585-1518
FAX: 801-585-3614

Email address: you.bae@utah.edu

Website: https://sites.google.com/site/baelabtestsite/home

Education and Training:

Ph.D., Pharmaceutics and Pharmaceutical Chemistry,
University of Utah
Salt Lake City, UT, 1980
B.s., Chemical Engineering,
Seoul National University
Korea, 1980

Research Interests:

Our main research interests are as follows:

Polymeric delivery systems for low molecular and macromolecular drugs and cells.

Selected Publications:

J.H. Maeng, D.H. Lee, K.H. Jung, Y.H. Bae, I.S. Park, S. Jeong, Y.S. Jeon, C.K. Shim, W. Kim, J. Kim, J. Lee, Y.M. Lee, J.H. Kim, W.H. Kim, S.S. Hong. "Multifunctional doxorubicin loaded superparamagnetic iron oxide nanoparticles for chemotherapy and magnetic resonance imaging in liver cancer", Biomaterials. 2010 (18): 4995-5006.
H.C. Kang, O. Samsonova, Y.H. Bae. "Trafficking microenvironmental pHs of polycationic gene vectors in drug-sensitive and multidrug-resistant MCF7 breast cancer cells", Biomaterials. 2010 31(11): 3071-8
V. Nadithe, Y.H. Bae, "Low p50 hemoglobin conjugated with antioxidant enzymes via poly (ethylene glycol) cross-linker (Hb-SOD-CAT) for protection of isolated cells in hypoxia". Biomacromol (submitted)
V. Nadithe, Y.H. Bae, "Synthesis and characterization of hemoglobin conjugates with antioxidant enzymes via poly(ethylene oxide) crosslinker (Hb-SOD-CAT) for protection from free radical stress", Biomacromol (submitted)
H. Yin, S.-W. Kang, Y.H. Bae*, "Polymersome formation from AB₂ type 3-miktoarm star copolymers", Macromolecules, 2009, 42(19), 7456-7464.
D. Kim, Z. Gao, E.S. Lee, Y.H. Bae*, "In vivo evaluation of doxorubicin loaded polymeric micelle targeting folate receptor and early endosomal pH with drug resistant ovarian cancer", Mol. Pharm. 2009, 6(5), 1353-1362.
S.-W. Kang and Y.H. Bae*, "Cryopreservable and tumorigenic three dimensional tumor culture in porous poly(lactic-co-glycolic acid) microsphere", Biomaterials 2009, 30, 4227-4232.
H.C. Kang, Y.H. Bae*, "Transfection of rat pancreatic islet tissue by polymeric gene vectors", Diab. Tech. & Thera. 2009, 11, 443-449.
H.C. Kang, Y.H. Bae*, "Transfection of insulin-secreting cell line and rat islets by functional polymeric gene vector", Biomaterials, 2009, 30, 2837-2845.
K.M. Park, H.C. Kang, J.K. Cho, I.-J. Chung, S.-H. Cho, Y.H. Bae, and K. Na*, "All-trans-retinoic acid (ATRA)-grafted polymeric gene carriers for nuclear translocation and cell growth control", Biomaterials 2009, 30, 2642-2652
Y.H. Bae*, "Drug targeting and tumor heterogeneity (perspective)", J. Control. Rel., 2009, 133, 2-3.
H. Yin, Y.H. Bae*, "Physicochemical aspects of doxorubicin-loaded pH-sensitive polymeric micelle formulations", Eur. J. Pharm. Biopharm. 2009, 71, 223-230.
D. Kim, Y.H. Bae, "Polymeric carriers for anticancer drugs", in Yi Lu, Ram I. Mahato (Eds.), Pharmaceutical Perspectives of Cancer Therapeutics, Springer, New York, USA. 2009, pp.207-244.
Y.S. Youn, K.C. Lee, Y.H. Bae, K. Na, E.S. Lee, "Advanced pulmonary delivery of peptides or proteins using polymeric particles", in L. Jorgenson and H. M. Nielson (Eds.), Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines, Wiley & Sons, Ltd., West Sussex, United Kingdom, 2009, pp.227-244.
H.C. Kang, E.S. Lee, K. Na, Y.H. Bae, "Stimuli-Sensitive Nanosystems: For Drug and Gene Delivery", in Vladimir P. Torchilin (Ed), Series: Fundamental Biomedical Technologies, Vol. 4. Multifunctional Pharmaceutical Nanocarriers, Springer, New York, USA. 2008, pp. 161-199.
D. Kim, E.S. Lee, K.T. Oh, Z. Gao, Y.H. Bae*, "Doxorubicin-loaded polymeric micelle overcomes multidrug resistance of cancer by double-targeting folate receptor and early endosomal pH", Small 2008, 4, 2043-2050.
Y.H. Bae*, H. Yin, "Stability issues of polymeric micelles (perspective)", J. Control. Rel. 2008, 131, 2-4.
E.S. Lee, Y.H. Bae*, "Recent Progress in Tumor pH Targeting", J. Control Rel., 2008, 132, 164-170. (review article).
D. Kim, E.S. Lee, K.S. Park, I.C. Kwon, Y.H. Bae*, "Doxorubicin loaded pH-sensitive mixed micelle: antitumoral efficacy against ovarian A2780/DOX^R tumor", Pharm. Res., 2008, 5, 2074-2082.
B.S. Jin, H.C. Kang, D. Kim, K.H. Lee, Y.H. Bae*, "Synthesis of poly(cystine bisamide)-PEG block copolymers grafted with 1-(3-aminopropyl) imidazole and their phase transition behaviors", Polymer for Advanced Technologies, 2008, 19, 1558-1565.
E.S. Lee, Z. Gao, D. Kim, K. Park, I.C. Kwon, Y.H. Bae, "Super pH-sensitive multifunctional polymeric micelle for tumor pHe specific TAT exposure and multidrug resistance", J. Control. Rel. 2008, 129, 228-236.
K.T. Oh, E.S. Lee, D.I. Kim, H. Yin, Y.H. Bae, "L-Histidine based pH-sensitive anticancer drug carrier micelle: Reconstitution and brief evaluation of its systemic toxicity", Int. J. Pharm. 2008, 358(1-2), 177-183.
A. Taluja, Y.S. Youn, Y.H. Bae, "Role of a novel multifunctional excipient poly(ethylene glycol)-b-oligo (vinyl sulfadimethoxine) in protein delivery from poly(lactide-co-glycolide) microspheres", Int. J. Pharm. 2008, 358(1-2), 50-59.
H. Yin, E.S. Lee, K.T. Oh, D.I. Kim, Y.H. Bae, "Physicochemical properties of pH-sensitive poly(L-histidine)-b-poly(ethylene glycol)/ poly(L-lactide)-b-poly(ethylene glycol) mixed micelles", J. Control. Rel., 2008, 126(2), 130-138.
V.A. Sethuraman, M.C. Lee, Y.H. Bae*, "A biodegradable pH-sensitive micelle system for targeting acidic solid tumors", Pharm. Res. 2008, 25(3), 657-666. (JIF 3.441 in 2007)
E.S. Lee, D. Kim, Y.S. Youn, K.T. Oh, and Y.H Bae, "A novel virus-mimetic nanogel vehicle", Angew. Chem. Int. Ed., 2008, 47(13), 2418-2421.
Y.H. Bae, U.S. Patent 7,371,781, "Tumor environment-induced ligand expressing system" (2008)
E.S. Lee, Y.H. Bae, "pH-Sensitive micelles targeting tumor pH", in M. Amiji (Ed.), Nanotechnology for Cancer Therapeutics, CRC Press 2007, pp. 443-464.
H.C. Kang, M.H. Lee, Y.H. Bae, "Polymeric gene delivery vectors", in N.A. Peppas, J. Zach Hilt, and J. Brook (Eds), Nanotechnology in Therapeutics: Current Technology and Applications, Horizon Bioscience Press. 2007, pp. 131-161.
E.S. Lee, D. Kim, Y.S. Youn, K.T. Oh, and Y.H Bae, "A novel virus-mimetic nanogel vehicle", Angew. Chem. Int. Ed., 2008, 47(13), 2418-2421.
E.S. Lee, K.T. Oh, D. Kim, Y.S. Youn, Y.H. Bae*, "Tumor pH-responsive flower-like micelle of poly(L-lactic acid)-b-poly(ethylene glycol)-b-poly(L-histidine)". J. Control. Rel. 2007, 123(1), 19-26.
K. Na, E.S. Lee, Y.H. Bae*, "Self-organized nanogels responding to tumor extracellular pH: pH-dependent drug release and in vitro cytotoxicity against MCF-7 wild and resistant cells". Bioconj. Chem. 2007, 18(5), 1568-1574.
A. Taluja, Y.S. Youn, Y.H. Bae*, "Novel approaches in microparticulate PLGA delivery systems encapsulating proteins". J. Mater. Chem. 2007, 17, 4002-4014. (review article).
K.T. Oh, H. Yin, E.S. Lee, Y.H. Bae*, "Polymeric nanovehicles for anticancer drugs with triggering release mechanisms", J. Mater. Chem. 2007, 17, 3987-4001. (review article).
L. Qiu, Y.H. Bae*, "Self-assembled polyethylenimine-graft-poly(e-caprolactone) micelles as dual carrier of genes and anticancer drugs", Biomaterials, 2007, 28(28), 4132-4142.
G. Mohazer, E.S. Lee, Y.H. Bae*, "Enhanced Intercellular Retention Activity of a Novel pH-sensitive Polymeric Micelles in Wild and Multidrug Resistant MCF-7 Cells", Pharm. Res. 2007, 24(9), 1618-1627.
A. Taluja, Y.H. Bae*, "Role of a novel excipient poly(ethylene glycol)-b-poly(L-histidine) in retention of physical stability of insulin at the aqueous/organic solvent interface", Mol. Pharm. 2007, 4(4), 561-570.
A. Taluja, Y.H. Bae*, "Role of a novel excipient poly(ethylene glycol)-b-poly(L-histidine) in retension of physical stability of insulin in aqueous solutions", Pharm. Res. 2007, 24, 1517-26.
H.C. Kang, Y.H. Bae*, "pH-Tunable endosomolytic oligomers for enhanced nucleic acid delivery", Advanced Functional Materials, 2007, 17, 1263-1272.
V. Sethuraman and Y.H. Bae*, "TAT peptide based micelle system for active targeting of anti cancer agents to acidic solid tumors", J. Control. Rel., 2007, 118, 216-224.
Y.H. Bae, U.S. Patent 7,229,973, "pH-sensitive polymeric micelle for drug delivery" (2007)