Current Publications

2015 Publications

  • Arauchi, C.-H. Yang, Y.-E. Sun, S. Cho, E.A. Jarboe, C.M. Peterson, Y.H. Bae, T. Okano, and M.M. Janát-Amsbury*, An immunocompetent, orthotopic mouse model of epithelial ovarian cancer utilizing tissue engineered tumor cell sheets, Tissue Eng. Part C: Methods, 2015, 21(1), 23-34.               
  • K. Yoon, H.C. Kang, L. Li, H. Cho, M.-K. Park, E. Lee, Y.H. Bae*, K.M. Huh* Amphiphilic poly(ethylene glycol)-poly(ε-caprolactone) AB2 miktoarm copolymers for self-assembled nanocarrier system: synthesis, characterization, and morphological effect on anti-tumor effect, Polymer Chemistry 2015, 6, 531-542. (cover page story).
  • J.-W. Choi, S.-J. Jung, D. Kasala, J.K. Hwang, J. Hu, Y.H. Bae*, C.-O.Yun* pH-sensitive oncolytic adenovirus hybrid targeting acidic tumor microenvironment and angiogenesis, J. Control. Release, 2015, 205, 134-143.
  • J.W. Park, S.J. Kim, D.S. Kwag, S. Kim, J. Park, Y.H. Bae, E.S. Lee*, Multifunctional delivery systems for advanced oral uptake of peptide/protein drugs, Current Pharmaceutical Design, 2015, 21(22), 3097-3110.
  • H. Park, S. Cho, Y.H. Han, M. Janat-Amsbury, S. Boudina, Y.H. Bae*, Combinatotial gene construct and non-viral delivery for antiobesity in diet induced obese mice, J. Control. Release, 2015, 207, 154-162.
  • H.C. Kang*, H. Cho, YH Bae*, DNA polyplex as a combinatory drug carrier of doxorubicin and cisplatin: In vitro study. Mol. Pharm., 2015, 12(8), 2845-2857.
  • D.L. Stirland, J.W. Nichols, E. Jarboe, M. Adelman, M. Dassel, M.-M. Janát-Amsbury, and Y.H. Bae* Uterine perfusion model for analyzing barriers to transport in fibroids, J. Control. Release, 2015, 214, 85-93.
  • H. Cho, Y.J. Lee, Y. H. Bae, H.C. Kang, Synthetic polynucleotides as endosomolytic agents and bioenergy sources J. Control Release (Concept Paper), 2015, 216, 30-36.
  • H. Park, S.Cho, M. Janat-Amsbury, Y.H. Bae, Enhanced thermogenic program by non-viral delivery of combinatory browning genes to treat diet-induced obesity, Biomaterials 2015, 73, 32-41.         
  • J.-W. Choi, D. Kasala, S.-J. Jung, J.K. Hwang, S.-H. Lee, D. Kim, J. Hu, Y.H. Bae*, C.-O.Yun* Enhanced anti-tumor efficacy and safety profile of tumor microenvironment-responsive oncolytic adenovirus nanocomplex by systemic administration, Acta Biomatrialia, 2015, 28, 86-98
  • S. Cho, H. Park, E.A. Jarboe, C.M. Peterson, Y.H. Bae, M. Janat-Amsbury*, Design and characterization of bioengineered cancer-like stem cells, PLoS ONE, 2015 10(10), e0141172.
  • Cho, S., Dong, S., Parent, K. N., & Chen, M. (2015). Immune-tolerant elastin-like polypeptides (iTEPs) and their application as CTL vaccine carriers. Journal of Drug Targeting
  • Mastria, E. M., Chen, M., McDaniel, J. R., Li, X., Hyun, J., Dewhirst, M. W., & Chilkoti, A. (2015). Doxorubicin-conjugated polypeptide nanoparticles inhibit metastasis in two murine models of carcinoma. Journal of Controlled Release
  • Zhang, J., Kale, V., & Chen, M. (2015). Gene-Directed Enzyme Prodrug Therapy. The AAPS journal, 17(1), 102-110.
  • N. Frazier, R. Robinson, A. Ray, and H. Ghandehari, Effects of Heating Temperature and Duration by Gold Nanorod Mediated Plasmonic Photothermal Therapy on Copolymer Accumulation in Tumor Tissue, Molecular Pharmaceutics, 12:1605-14 (2015).
  • S.H. Jung, J.W. Choi, C.O. Yun, S.H. Kim, I.C. Kwon, and H. Ghandehari, Direct Observation of Interactions of Silk-Elastinlike Protein Polymer with Adenoviruses and Elastase. Molecular Pharmaceutics, 12:1673-1679 (2015).
  • H.L. Herd, K.T. Bartlett, J.A. Gustafson, L.D. McGill, and H. Ghandehari, Macrophage Silica Nanoparticle Response is Phenotypically Dependent, Biomaterials, 53:574-82 (2015).
  • A. Poursaid, R. Price, A. Tiede, E. Olson, E. Huo, L. McGill, H. Ghandehari*, and J. Cappello*, In Situ Gelling Silk-Elastinlike Protein Polymer for Transarterial Chemoembolization, Biomaterials, 57:142-52 (2015). *Corresponding Coauthors.
  • N. Frazier, and H. Ghandehari, Hyperthermia Approaches for Enhanced Delivery of Nanomedicines to Solid Tumors, Biotechnology and Bioengineering. 112:1967-83 (2015).
  • R. Price, A. Poursaid, J. Cappello, and H. Ghandehari, In Vivo Evaluation of Matrix Metalloproteinase Responsive Silk-Elastinlike Protein Polymers for Cancer Gene Therapy, Journal of Control Release, 213:96-102 (2015).
  • D.Hubbard, T. Bond, and H. Ghandehari. Regional Morphology and Transport of PAMAM Dendrimers Across Isolated Rat Intestinal Tissue. Macromolecular Biosciences, 15:1735-43 (2015).
  • H. Ghandehari, ADDR Editor's Collection. Advanced Drug Delivery Reviews, 91:1-2 (2015).
  • D. Hubbard, M. Enda, T. Bond, S.P. Moghaddam, J. Conarton, C. Scaife, E. Volckmann, and H. Ghandehari, Transepithelial Transport of PAMAM Dendrimers Across Isolated Human Intestinal Tissue, Molecular Pharmaceutics, 12:4099-107 (2015).
  • R. Robinson, W. Gerlach, and H. Ghandehari. Comparative Effect of Gold Nanorods and Nanocages for Prostate Tumor Hyperthermia, Journal of Control Release. 220(Pt A):245-52 (2015).
  • H. Herd, J. Gustafson, D. Holt-Casper, D. W. Grainger*, and H. Ghandehari*, Nanoparticle Uptake: The Phagocyte Problem, Nano Today, 10, 487-510 (2015). *Corresponding coauthors.
  • D.E. Jones, H. Ghandehari, J.C. Facelli, Beilstein Journal of Nanotechnology, Predicting Cytotoxicity of PAMAM Dendrimers Using Molecular Descriptors, 6:1886-96 (2015).
  • B. Buckway, N. Frazier, A.J. Gormley, A. Ray, and H. Ghandehari, Gold Nanorod-Mediated Hyperthermia Enhances the Efficacy of HPMA Copolymer-90Y Conjugates in Treatment of Prostate Tumors. Nuclear Medicine and Biology, 41: 282-289 (2014)
  • B. Buckway, Y. Wang,  A. Ray, and H. Ghandehari,  In Vitro Evaluation of HPMA-Copolymers Targeted to HER2 Expressing Pancreatic Tumor cells for Image Guided Drug Delivery. Macromolecular Bioscience, 14: 92-99 (2014)
  • D. Hubbard, D. J. Brayden, and H. Ghandehari, Nanopreparations for Oral Administration, In Frontiers of Nanobiomedical Research - Vol II, World Scientific Publishing Co Pte Ltd, Chapter 5, in press
  • B.D. Brooks, K.D. Sinclair, D.W. Grainger, A.E. Brooks, “A Resorbable Antibiotic-Eluting Polymer Composite Bone Void Filler for Perioperative Infection Prevention in a Rabbit Radial Defect Model,” PLoS One, 2015 Mar 27;10(3):e0118696. doi: 10.1371/journal.pone.0118696D. PMID: 25815727  
  • D. Holt, L.M. Chamberlain, M. Gonzalez-Juarrero, D.W. Grainger, “Extended culture of macrophages from different sources and maturation results in a common M2 phenotype”, J. Biomed. Mater. Res. A., (2015) doi: 10.1002/jbm.a.35415. [Epub ahead of print] PMID: 25684281.
  • H.-D. Volk, M.M. Stevens, D.J. Mooney, D.W. Grainger, G.N. Duda, Key elements for nourishing the translational research environment. Sci. Transl. Med. 7, 282cm2 (2015). PMID: 25855490
  • D.W. Grainger, “Wound healing: enzymatically crosslinked scaffolds,” Nature Materials 14, 662–663 (2015) doi:10.1038/nmat4337, 2015. (PMID 26099714)
  • M.  Hofmann-Amtenbrink, D.W. Grainger, H. Hofmann, “Nanoparticles in Medicine: Current Challenges Facing Inorganic Nanoparticle Toxicity Assessments and Standardizations,” Nanomedicine, 2015, 11(7) 1689–1694; DOI: http://dx.doi.org/10.1016/j.nano.2015.05.005. PMID: 26051651
  • D.W. Grainger, “Fat prospects for healing cutaneous wounds: new activities under the sheets,” Diabetes (commentary), 64 2717-2719 2015
  • J. Auer, D.W. Grainger, “Fracture management in horses: Where have we been and where are we going?”, Vet. J., ePub June 20, 2015; doi: 10.1016/j.tvjl.2015.06.002. (PMID 26095036)
  • J. Falconer, S. Lu, C. Jones, D.W. Grainger, “Carbon Nanomaterials Rescue Polyaromatic Hydrocarbon Toxicity in Zebrafish Embryo Cultures”, Environ. Sci. Nano, 2015, 2, 645 – 652; DOI: 10.1039/C5EN00111K.
  • D.J. Holt, A. Moreno, M. Warren, J.M. Theisen, D.W. Grainger, D.A. Bull, A.N. Patel, Highly cellularized three-dimensional human heart matrix-derived scaffolds, J. Trans. Med., 13:194, 2015. (PMID 26084398)
  • H. Herd Gustafson, D. Holt-Casper, D.W. Grainger, H. Ghandehari, “Nanoparticle Uptake: The Phagocyte Problem“, NanoToday, e-pub, 2015; doi:10.1016/j.nantod.2015.06.006. PMID: 26640510
  • K.D. Sinclair, Z.A. Farrell, B.D. Brooks, A.E. Brooks, D.W. Grainger, “A Resorbable Antibiotic-Eluting Polymer Composite Bone Void Filler for Periprosthetic Joint Infection Prevention”, J. Biomed. Mater. Res. B., ePub 2015; doi: 10.1002/jbm.b.33513. PMID: 25815727
  • M. Avula, D. Jones; A. Rao, D. McClain, L.D. McGill, D.W. Grainger; F. Solzbacher, “Local release of masitinib alters in vivo implantable continuous glucose sensor performance”, Biosensor Bioelectron. (2016) 77 149–156;10.1016/j.bios.2015.08.059, 2015. PMID: 26402593
  • J. L. Falconer, R.J. Christie, E.J. Pollard, S.C. Olsen, D.W. Grainger, “Live RB51 Vaccine Lyophilized Hydrogel Formulations with Increased Shelf Life for Practical Ballistic Delivery,” Int. J. Pharm, in press, 2015. PMID: 26705151
  • VEGF Therapeutic Gene Delivery Using Dendrimer Type Bio-reducible Polymer into Human Mesenchymal Stem Cells (hMSCs), H.Kim, K. Nam, J-P. Nam, H.S. Kim, Y.M. Kim, W.S. Joo, and S.W. Kim. Journal of Controlled Release, 220:222-228 (2015).
  • Heptoma Targeting Peptide Conjugated Bio-reducible Polumer Complexed with Oncolytic Adenovirus for Cancer Gene Therapy, J-W. Choi, H.A. Kim, K. Nam, Y. Na, and S.W. Kim.  Journal of Controlled Release, 220:691-703 (2015)
  • Poly(ethylenimine) Conjugated Bioreducible Dendrimer for Efficient Gene Delivery, K. Nam, S. Jung, J-P. Nam and S.W. Kim. Journal of Controlled Release, 220:447-455 (2015).
  • Polymeric Oncolytic Adenovirus for Cancer Gene Therapy, J-W. Choi, Y.S. Lee, C-O. Yun, and S.W. Kim. Journal of Controlled Release, 219:181-191 (2015).     PMCID: PMC4668934
  • Tuning Surface Charge and PEGylation of Biocompatible Polymers for Efficient Delivery of Nucleic Acid or Adenoviral Vector, J-W. Choi, J. Kim, Q.N. Bui, Y. Li, C-O.Yun, D.S. Lee and S.W. Kim. Bioconjugate Chemistry, 26(8):1818-1829 (2015)
  • Evaluation of Dendrimer Type Bio-reducible Polymer as a siRNA Delivery Carrier for Cancer Therapy, J-P. Nam, K. Nam, S. Jung, J-W. Nah, S.W. Kim.  Journal of Controlled Release, 209(10):179-185 (2015)
  • Effective Gene Delivery into HumanStem Cells with a Cell-Targeting Peptide-Modified Bioreducible Polymer, J. Beloor, S. Ramakrishna, K. Nam, C.S. Choi, J. Kim,S.H. Kim, H.J. Cho, H.S. Shin, H. Kim, S.W. Kim, S-K. Lee and P. Kumar. Small, 11(17): 2069–2079 (2015).
  • Development of Porous PLGA/PEI1.8k Biodegradable Microspheres for the Delivery of Mesenchymal Stem Cells (MSCs), Y.S. Lee, K.S. Lim, J-E. Oh, A-R. Yoon, W.S. Joo, H.S. Kim, C-O. Yun and S.W. Kim. Journal of Controlled Release, 205:128-133 (2015)
  • Dual Tumor Targeting with pH-sensitive and Bioreducible Polymer-complexed Oncolytic Adenovirus, C.Y. Moon, J-W. Choi, D. Kasala, S-J. Jung, S.W. Kim and C-O. Yun. Biomaterials, 41:53-68 (2015)
  • Safety Profiles and Antitumor Efficacy of Oncolytic Adenovirus Coated with Bioreducible Polymer in the Treatment of a CAR Negative Tumor Model, S-J. Jung, D. Kasala, J-W. Choi, S-H. Lee, J.K. Hwang, S.W. Kim and C-O. Yun. BioMacromolecules, 16(1):87-96 (2015).     PMCID: PMC4294585
  • T.-W. Chu, R. Zhang, J. Yang, M.P. Chao, P.J. Shami, J. Kopeček, A Two-Step Pretargeted Nanotherapy for CD20 Crosslinking May Achieve Superior Anti-Lymphoma Efficacy to Rituximab. Theranostics 5, 834-846 (2015).
  • J. Yang, R. Zhang D.C. Radford, J. Kopeček, FRET-Trackable Biodegradable HPMA Copolymer-Epirubicin Conjugates for Ovarian Carcinoma Therapy. J. Controlled Release 218, 36-44 (2015).
  • Z.-H. Peng, J. Kopeček, Enhancing Accumulation and Penetration of HPMA Copolymer Doxorubicin Conjugates in 2D and 3D Prostate Cancer Cells via iRGD Conjugation with an MMP-2 Cleavable Spacer. J. Am. Chem. Soc. 137, 6726-6729 (2015). 
  • R. Zhang, J. Yang, T.-W. Chu, J.M. Hartley, J. Kopeček, Multimodality Imaging of Coiled-Coil Mediated Self-Assembly in a “Drug-Free” Therapeutic System. Adv. Healthcare Mat. 4, 1054-1065 (2015). 
  • J.M. Hartley, T.-W. Chu, E.M. Peterson, R. Zhang, J. Yang, J. Harris, J. Kopeček, Super-Resolution Imaging and Quatitative Analysis of Membrane Protein/Lipid Raft Clustering Mediated by Cell Surface Self-Assembly of Hybrid Nanoconjugates. ChemBioChem 16, 1725-1729 (2015)
  • J. Yang, J. Kopeček, Polymeric Biomaterials and Nanomedicines. J. Drug Deliv. Sci. Technol. 30, 318-330 (2015)
  • S.A. Low, C.V. Galiford, J. Yang, P.S. Low, J. Kopeček, Biodistribution of Facture-Targeted GSK3β Inhibitor-Loaded Micelles for Improved Fracture Healing. Biomacromolecules 16, 3145-3153 (2015)
  • T.-W. Chu, J. Feng, J. Yang, J. Kopeček, Hybrid Polymeric Hydrogels via Peptide Nucleic Acid (PNA)/DNA Complexation. J. Controlled Release 220, 608-616 (2015)
  • T.-W. Chu, J. Kopeček, Drug-Free Macromolecular Therapeutics – A New Paradigm in Polymeric Nanomedicines. Biomaterials Sci. 3, 908-922 (2015). 
  • J. Yang, J. Kopeček, Backbone Degradable and Coiled-Coil Based Macromolecular Therapeutics. In: Bioinspired Systems for Drug, Protein and Gene Delivery, Z.W. Gu, Ed., Chapter 1, pp. 1-27, Wiley 2015; ISBN: 978-3-527-33420-9.
  • J. Yang, J. Kopeček, Design of Smart HPMA Copolymer-Based Nanomedicines. J. Controlled Release (2015) http://dx.doi.org/10.1016/j.jconrel.2015.10.003
  • R. Zhang, J. Yang, Y. Zhou, P.J. Shami, J. Kopeček, N-(2-Hydroxypropyl)methacrylamide Copolymer-drug Conjugates for Combination Chemotherapy of Acute Myeloid Leukemia. Macromol. Biosci. (2015) doi: 10.1002/mabi201500193
  • Lu P, Bruno BJ, Rabenau M, Lim CS (2015). Delivery of drugs and macromolecules to the mitochondria for cancer therapy. J. Ctrl Rel, in press.
  • Woessner DW, Eiring AM, Bruno BJ, Zabriskie MS, Reynolds KR, Miller GD, O'Hare T, Deininger MW, Lim CS (2015). A coiled-coil mimetic intercepts BCR-ABL1 dimerization in native and kinase-mutant chronic myeloid leukemia. Leukemia, 29(8):1668-75
  • Bruno BJ, Lim CS (2015). Inhibition of bcr-abl in human leukemic cells with a coiled-coil protein delivered by a leukemia-specific cell-penetrating Peptide. Mol Pharm, 12(5), 1412-21 
  • S.A. Fisher, P.N. Anandakumaran, S.C. Owen, M.S. Shoichet, Tuning the Microenvironment: Click‐Crosslinked Hyaluronic Acid‐Based Hydrogels Provide a Platform for Studying Breast Cancer Cell Invasion, Advanced Functional Materials, 2015, 25 (46), 7163-7172
  • J.R. McCombs, S.C. Owen, Antibody drug conjugates: design and selection of linker, payload and conjugation chemistry, The AAPS journal, 2015, 17 (2), 339-351



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