The Department of Pharmaceutics & Pharmaceutical Chemistry

Publications

2013 Publications

          • DL Stirland, JW Nichols, S Miura, YH Bae
            Mind the gap: A survey of how cancer drug carriers are susceptible to the gap between research and practice
            Journal of Controlled Release 172 (3), 1045-1064
          • pH-responsive and charge shielded cationic micelle of poly(l-histidine)-block-short branched PEI for acidic cancer treatment
            J Hu, S Miura, K Na, YH Bae
          • Journal of Controlled Release 172 (1), 69-76
            H Yim, S Park, YH Bae, K Na
            Biodegradable cationic nanoparticles loaded with an anticancer drug for deep penetration of heterogeneous tumours
            Biomaterials 34 (31), 7674-7682
          • L Tian, HC Kang, YH Bae
            Endosomolytic reducible polymeric electrolytes for cytosolic protein delivery
            Biomacromolecules 14 (8), 2570-2581
          • HS Hwang, HC Kang, YH Bae
            Bioreducible Polymers As a Determining Factor for Polyplex Decomplexation Rate and Transfection
            Biomacromolecules 14 (2), 548-556
          • V.H. Lee, H. Ghandehari, Advanced Drug Delivery: Perspectives and Prospects. Preface, Advanced Drug Delivery Reviews, 65:1-2 (2013)
          • G.Thiagarajan, S. Sadekar, K. Greish, A. Ray, H. Ghandehari, Evidence of Oral Translocation of Anionic G6.5 Dendrimers in Mice. Molecular Pharmaceutics, 10: 988-98 (2013)
          • A.J. Gormley, N. Larson, A. Banisadr, R. Robinson, N. Frazier, A. Ray, H. Ghandehari , Plasmonic Photothermal Therapy Increases the Tumor Mass Penetration of HPMA Copolymers. Journal of Controlled Release, 166: 130-8 (2013)
          • H. Herd, N. Daum, A. Jones, H. Huwer, H. Ghandehari, C.M. Lehr, Nanoparticle Geometry and Surface Orientation Influence Mode of Cellular Uptake, ACS Nano, 7: 1961-1973 (2013)
          • J. Gustafson, R. Price, J. Frandsen, C.R. Henak, J. Cappello, and H. Ghandehari, Synthesis and Characterization of Matrix-Metalloproteinase Responsive Silk-Elastinlike Protein Polymer, Biomacromolecules, 14: 618-625 (2013)
          • S. Sadekar, O. Linares, G. J. Noh , D. Hubbard, A. Ray, M.M. Janát-Amsbury, C. M. Peterson, J. Facelli, and H. Ghandehari, Comparative Pharmacokinetics of PAMAM-OH Dendrimers and HPMA Copolymers In Ovarian-Tumor-Bearing Mice, Drug Delivery and Translational Research, 3: 260-271 (2013)
          • G. Thiagarajan, K. Greish, and H. Ghandehari, Charge Affects the Oral Toxicity of Poly(amidoamine) Dendrimers, European Journal Pharmaceutics and Biopharmaceutics, 84: 330-334 (2013)
          • A.Gormley, N. Larson, and H. Ghandehari, Enhanced Delivery of Polymer Therapeutics to Solid Tumors, In Tailored Polymer Architectures for Pharmaceutical and Biomedical Applications, American Chemical Society Publisher, Chapter 10, pp 151-185 (2013)
          • N. Larson, A. Gormley, N. Frazier, and H. Ghandehari, Synergistic Enhancement of Cancer Therapy Using a Combination of Heat Shock Protein Targeted HPMA Copolymer-Drug Conjugates and Gold Nanorod Induced Hyperthermia, Journal of Controlled Release, 170: 41-50 (2013)
          • N. Larson, J. Yang, A. Ray, D.L. Cheney, H. Ghandehari, and J. Kopecek, Biodegradable Multiblock Poly(N-2-Hydroxypropyl)Methacrylamide Gemcitabine and Paclitaxel Conjugates for Ovarian Cancer Cell Combination Treatment, International Journal of Pharmaceutics, 454: 435-443 (2013)
          • B. Buckway, N. Frazier, A.J. Gormley, A. Ray, and H. Ghandehari, Gold Nanorod-Mediated Hyperthermia Enhances the Efficacy of HPMA Copolymer-90Y Conjugates in Treatment of Prostate Tumors. Nuclear Medicine and Biology, 41: 282-289 (2014)
          • B. Buckway, Y. Wang, A. Ray, and H. Ghandehari, In Vitro Evaluation of HPMA-Copolymers Targeted to HER2 Expressing Pancreatic Tumor cells for Image Guided Drug Delivery. Macromolecular Bioscience, 14: 92-99 (2014)
          • D. Hubbard, D. J. Brayden, and H. Ghandehari, Nanopreparations for Oral Administration, In Frontiers of Nanobiomedical Research - Vol II, World Scientific Publishing Co Pte Ltd, Chapter 5, in press.
          • D.W. Grainger, “Connecting drug delivery reality to smart materials design,” Int. J. Pharm, 454 (2013) 521-524; doi:10.1016/j.ijpharm.2013.04.061.
          • K.J. Smock, R.L. Schmidt, G. Hadlock, G. Stoddard, D.W. Grainger, M.A. Munger, “Assessment of Orally Dosed Commercial Silver Nanoparticles on Human ex vivo Platelet Aggregation,” Nanotoxicol., ePub, May, 2013 (PMID 2351708). DOI: 10.3109/17435390.2013.788749
          • M.A. Munger, P. Radwanski, G. Hadlock, G. Stoddard, A. Shaaban, J. Falconer, D.W. Grainger, G. Yost, “In vivo human time-exposure study of orally dosed commercial silver nanoparticles,” Nanomedicine: NBM, 2013;xx:1-9, http://dx.doi.org/10.1016/j.nano.2013.06.010.
          • D.W. Grainger, “All charged up about biomaterials,” (News and Views), Nature Biotechnol., 31, 507–509 (2013) doi:10.1038/nbt.2600.
          • A.E. Brooks, B.D. Brooks, S.N. Davidoff, P.C. Hogrebe, M.A. Fisher, and D.W. Grainger, “Polymer-controlled release of tobramycin from bone graft void filler,” Drug Deliv. Transl. Res., (2013) 3:518–530; DOI 10.1007/s13346-013-0155-x
          • D.W. Grainger, H.C. van der Mei, P.C. Jutte, J.J.A.M. van den Dungen, M.J. Schultz, B.F.A.M. van der Laan, S.A.J. Zaat, H.J. Busscher, “Critical factors in the translation of improved antimicrobial strategies for medical implants and devices”, Biomaterials, 2013 Dec;34(37):9237-43. doi: 10.1016/j.biomaterials.2013.08.043. Epub 2013 Sep 11, PMID: 24034505.
          • Y. Wang, D.W. Grainger, “Developing siRNA therapies to address osteoporosis“, Therap. Deliv., 4(10):1239-46 (2013). doi: 10.4155/tde.13.85.
          • M.N. Avula, A. Rao, L.D. McGill, F. Solzbacher, D.W. Grainger, “Modulation of the foreign body response to implanted sensor models through device-based delivery of the tyrosine kinase inhibitor, masitinib, Biomaterials 34 9737-9746 (2013), http://dx.doi.org/10.1016/j.biomaterials.2013.08.090.
          • B. Brooks, A.E. Brooks, D.W. Grainger, “Molded Polymer-Coated Composite Bone Void Filler Improves Tobramycin Controlled Release Kinetics", J. Biomed. Mat. Res. B (Appl. Biomaterials), in press, 2013.
          • F.J. Silva, D.J. Holt, V. Vargas, S. Boudina, J. Yockman, D. Atkinson, D.W. Grainger, M.P. Revelo, W. Sherman, D.A. Bull, A.N. Patel, “Metabolically active human brown adipose tissue derived stem cells”, Stem Cells, in press, 2013.
          • M. Avula, A. Rao, F. Solzbacher, D.W. Grainger, “Foreign Body Response To Subcutaneous Biomaterial Implants in a Mast Cell-deficient Kitw-Sh Murine Model,” Acta Biomateriala, in press, 2013.
          • S. Davidoff, B. Brooks, D.W. Grainger, A.E. Brooks, “Comparisions of release of several antibiotics from antimicrobial polymer-coated allograft bone void filler,” Intl J. Biomed. Mat. Res., in press, 2013.
          • B. Brooks, D.W. Grainger, B. Gale, “A Critical Comparison of Protein Microarray Fabrication Technologies”, Analyst, in press, (2013).
          • A. Rao, D.W. Grainger, “Biophysical aspects of nucleic acids on surfaces relevant to microarray performance, Biomaterials. Sci., in press (2013).
          • Y. Wang, J. Liu, J. Zhang, L. Wang, J. Chan, H. Wang, Y. Jin, L. Yu, D.W. Grainger, W. Ying, “A cell-based pharmacokinetics assay for evaluating tubulin-binding drugs,” Pharm. Res., submitted, 2013.
          • A. Astashkina, D.W. Grainger, “Influence of drug hydrophobicity, cell confluence, and assay selection on toxicity assessment in vitro in primary and transformed kidney cell cultures", Cell Biol Toxicol, submitted, 2013.
          • L. Gamble, D.H. Radford, D.A. Fischer, D.G. Castner, D.W. Grainger, "Quantitative Evaluation of Perfluorinated Alkylthiol Molecular Order on Gold Surfaces", Langmuir, under revision (2012).
          • W. R. Schief, Jr., J. Shumaker-Parry, D.W. Grainger, V. Vogel, "Ordered Domains in Hydrocarbon/Perfluorocarbon Binary Mixed Lipid Monolayers at the Air-Water Interface", Langmuir, in preparation (2013).
          • F. Parsapour, D.W. Grainger, "Interfacial Properties of Bound Perfluoropolyether-grafted Polysiloxane Monolayers on Silicon Oxide", Macromolecules, in preparation, (2013).
          • Synergistically Combined Gene Delivery for Enhanced VEGF Secretion and Anti-Apoptosis, Y-W. Won, M. Lee, H.A. Kim, K. Nam, D.A. Bull, and S.W Kim
          • Hypoxia/Hepatome Dual Specific Suicide Gene Expression Plasmid Delivery Using Bio-reducible Polymer for Hepatocellular Carcinoma Therapy, H.A. Kim, K. Nam, M. Lee and S.W. Kim. Journal of Controlled Release, 171(1):1-10 (2013).
          • Human Erythropoietin Gene Delivery for Cardiac Remodeling of Myocardial Infarction in Rats, Y. Lee, A.N. McGinn, C.D. Olsen, K. Nam, M. Lee, S.K. Shin, and S.W. Kim. Journal of Controlled Release, 171(1):24-32 (2013).
          • Enhanced siRNA Delivery Using a Combination of an Arginine-grafted Bioreducible Polymer, Ultrasound, and Microbubbles in Cancer Cells, S. Florinas, H.Y. Nam and S.W. Kim. Molecular Pharmaceutics, 10(5):2021-2030 (2013).
          • Targeted Gene Delivery to Ischemic Myocardium by Homing Peptide-guided Polymeric Carrier, Y-W. Won, A.N. McGinn, M. Lee, D.A. Bull and S.W. Kim. Molecular Pharmaceutics, 10(1):378-385 (2013).
          • Anti-apoptotic Cardioprotective Effects of SHP-1 Gene Silencing Against Ischemia-Reperfusion Injury: Use of Deoxycholic Acid-modified Low Molecular Weight Polyethyleneimine as a Cardiac siRNA-carrier, D. Kim, J. Hong, H.H. Moon, H.Y. Nam, H. Mok, J.H. Jeong, S.W. Kim, D. Choi and S.H. Kim. Journal of Controlled Release, 168(2):125-134 (2013).
          • Therapeutic Targeting of Chitosan-PEG-folate-complexed Oncolytic Adenovirus for Active and Systemic Cancer Gene Therapy, O.J. Kwon, K. Kang, J.W. Choi, S.W. Kim, and C-O. Yun. Journal of Controlled Release, 169(3):257-265 (2013).
          • Y. Zhou, J. Yang, J. Rhim, J. Kopeček, HPMA Copolymer-based Combination Therapy Toxic to both Prostate Cancer Stem/Progenitor Cells and Differentiated Cells Induces Durable Anti-tumor Effects. J. Controlled Release 172, 946-953 (2013)
          • J. Kopeček, Polymer – Drug Conjugates: Origins, Progress to Date and Future Directions.Adv. Drug Delivery Rev. 65, 49-59 (2013).
          • H. Pan, M. Sima, S.C. Miller, P. Kopečková, J. Yang, J. Kopeček, Promotion of Bone Formation in Ovariectomized Rats by High Molecular Weight Backbone Degradable HPMA Copolymer – Prostaglandin E1 Conjugate. Biomaterials 34, 6528-6538 (2013).
          • R. Zhang, K. Luo, J. Yang, M. Sima, Y. Sun, M.M. Janát-Amsbury, J. Kopeček, Synthesis and Evaluation of a Backbone Biodegradable Multiblock HPMA Copolymer Nanocarrier for the Systemic Delivery of Paclitaxel. J. Controlled Release 166, 66-74 (2013).
          • Y. Zhou, J. Kopeček, Biological Rationale for the Design of Polymeric Anti-Cancer Nanomedicines. J. Drug Targeting 21, 1-26 (2013).
          • H. Pan, M. Sima, J. Yang, J. Kopeček, Synthesis of Long-Circulating Backbone Degradable HPMA Copolymer-Doxorubicin Conjugates and Evaluation of Molecular Weight Dependent Antitumor Efficacy. Macromol. Biosci. 13, 155-160 (2013).
          • Z.-H. Peng, M. Sima, M.E. Salama, P. Kopečková, J. Kopeček, Spacer Length Impacts the Efficacy of Targeted Docetaxel Conjugates in Prostate Specific Membrane Antigen Expressing Prostate Cancer. J. Drug Targeting 21, 968-980 (2013).
          • N. Larson, J. Yang, A. Ray, D.L. Cheney, H. Ghandehari, J. Kopeček, Biodegradable Multiblock Poly(N-2-hydroxypropyl)methacrylamide Gemcitabine and Paclitaxel Conjugates for Ovarian Cancer Cell Combination Treatment. Int. J. Pharmaceutics 454, 435-443 (2013).
          • Duangjai, K. Luo, Y. Zhou, J. Yang, J. Kopeček, Combination Cytotoxicity of Backbone Degradable HPMA Copolymer Gemcitabine and Platinum Conjugates toward Human Ovarian Carcinoma Cells. Eur. J. Pharmaceutics Biopharm. (2013); http://dx.doi.org/ 10.1016/ j.ejpb.2013.11.008
          • Y. Zhou, J. Yang, J. Kopeček, Cancer Stem Cells: Potential Target for Anti-Cancer Nanomedicines. In: Tailored Polymer Architectures for Pharmaceutical and Biomedical Applications, C. Scholz, J. Kressler, Eds., ACS Symposium Series 1135, American Chemical Society, Washington, D.C., (2013), chapter 9, pp. 127-149.
          • Bruno B.J., Miller G.D., and Lim CS. Basics and Recent Advances in Peptide and Protein Drug Delivery. Therapeutic Delivery, 2013 Nov; 4(11):1443-1467, PMID: 24228993
          • Matissek K.J., Mossalam M., Okal A., Lim C.S. The DNA Binding Domain of p53 Is Sufficient To Trigger a Potent Apoptotic Response at the Mitochondria. Molecular Pharmaceutics, 2013 Oct 7; 10(10):3592-602, PMID: 23968395
          • Okal A., Mossalam M., Matissek K.J., Dixon A.S., Moos P.J., Lim C.S. A Chimeric p53 Evades Mutant p53 Transdominant Inhibition in Cancer Cells. Molecular Pharmaceutics, 2013 Oct 7; 10(10):3922-33, PMID: 23964676
          • Miller G.D., Woessner D.W., Sirch M.J., Lim C.S. Multidomain Targeting of Bcr-Abl by Disruption of Oligomerization and Tyrosine Kinase Inhibition: Toward Eradication of CML. Molecular Pharmaceutics, 2013 Sept 3; 10(9):3475-83, PMID:23915432
          • Davis J.R., Mossalam M., Lim C.S. Controlled Access of p53 to the Nucleus Regulates Its Proteasomal Degradation by MDM2. Molecular Pharmaceutics, 2013 Apr 1; 10(4): 1340-9, PMID:23398638, PMCID in progress.
          • Reaz S., Mossalam M., Okal A., Lim C.S. A Single Mutant, A276S of p53, Turns the Switch to Apoptosis. Molecular Pharmaceutics, 2013 Apr 1; 10(4):1350-9, PMID: 23402381, PMCID in progress.
          • Woessner, D.W. and Lim, C.S. Disrupting BCR-ABL in Combination with Secondary Leukemia-Specific Pathways in CML Cells Leads to Enhanced Apoptosis and Decreased Proliferation, Molecular Pharmaceutics, 2013 Jan 7, 10 (1): 270–277 PMID:2321103; PMCID: PMC3604893 [Available on 2014/1/7]
          • Okal, A., Reaz, S., and Lim, C.S. Cancer Biology: Some Causes for a Variety of Different Diseases, invited book chapter in "Cancer Targeted Drug Delivery: Elusive Dream," editors Bae, Y.H., Mrsny, R., and Park, K. (Springer), 2013, XVII.
          • Click conjugated polymeric immuno-nanoparticles for targeted siRNA and antisense oligonucleotide delivery.
            Chan DP, Deleavey GF, Owen SC, Damha MJ, Shoichet MS.
            Biomaterials. 2013 Nov;34(33):8408-15. doi:10.1016/j.biomaterials.2013.07.019. Epub 2013 Aug 7. PMID: 23932248
          • Targeting HER2+ breast cancer cells: lysosomal accumulation of anti-HER2 antibodies is influenced by antibody binding site and conjugation to polymeric nanoparticles.
            Owen SC, Patel N, Logie J, Pan G, Persson H, Moffat J, Sidhu SS, Shoichet MS.J Control Release. 2013 Dec 10;172(2):395-404. doi: 10.1016/j.jconrel.2013.07.011. Epub 2013 Jul 21.PMID: 23880472
          • Hyaluronic acid click hydrogels emulate the extracellular matrix.
            Owen SC, Fisher SA, Tam RY, Nimmo CM, Shoichet MS.
            Langmuir. 2013 Jun 18;29(24):7393-400. doi: 10.1021/la305000w. Epub 2013 Feb 18.
            PMID: 23343008
          • Double click: dual functionalized polymeric micelles with antibodies and peptides.
            Chan DP, Owen SC, Shoichet MS.
            Bioconjug Chem. 2013 Jan 16;24(1):105-13. doi: 10.1021/bc300511a. Epub 2013 Jan 4.
            PMID: 23289801

2012 Publications

          • Biocompatible, pH-sensitive AB(2) Miktoarm Polymer-Based Polymersomes: Preparation,
            Characterization and Acidic pH-Activated Nanostructural Transformation.
            Yin H. Kang HC, Huh KM, Bae YH.
            J. Mater Chem. 2012 Sep 28; 91968-19178. [PubMed].
          • Thermo-sensitive Sol-Gel Reversible Hydrogels.
            Jeong B, Kim SW, Bae YH.
            Adv. Drug Deliv. Rev. 2012 Sep 13. Epub.
          • Interview with Dr. You Han Bae: Ligand -Mediated Versus 'Passive' Targeting Approaches in
            Nanparticle Oncology Research.
            Bae YH.
            Ther. Deliv. 2012 Aug;3(8):933-6. [PubMed].
          • Polymeric Nucleic Acid Carriers: Current Issues and Novel Design Approaches.
            Kang HC, Huh KM, Bae YH.
            J. Control Release. 2012 Jul 4.
          • Nanoscaled Buffering Zone of Charged (PLGA)n-b-bPEI Micelles in Acidic Microclimate for
            Potential Protein Delivery Application.
            Kang HC, Lee JE, Bae YH.
            J. Control Release. 2012 Jun 28;160(3):440-50. Epub 2012 Mar 3.
          • Influence of Geometry, Porosity, and Surface Characteristics of Silica Nanoparticles
            on Acute Toxicity: their Vasculature Effect and Tolerance Threshold.
            Yu T, Greish K, McGill LD, Ray A, Ghandehari H.
            ACS Nano. 2012 Mar 27;6(3):2289-301. Epub 2012 Mar 2.
          • Recombinant Protein-Based Polymers for Advanced Drug Delivery.
            Frandsen JL, Ghandehari H.
            Chem Soc Rev. 2012 Apr 7;41(7):2696-706. Epub 2012 Feb 17.
          • Transepithelial Transport and Toxicity of PAMAM Dendrimers: Implications for Oral Drug Delivery.
            Sadekar S,Ghandehari H.
            Adv Drug Deliv Rev. 2012 May 1;64(6):571-88. Epub.
          • Comparison of Silk-Elastinlike Protein Polymer Hydrogel and Poloxamer in Matrix-Mediated Gene Delivery.
            Price R, Gustafson J, Greish K, Cappello J, McGill L, Ghandehari H.
            Int. J. Pharm. 2012 May 1;427(1):97-104. Epub.
          • Guided Delivery of Polymer Therapeutics Using Plasmonic Photothermal Therapy.
            Gormley AJ, Larson N, Sadekar S, Robinson R, Ray A, Ghandehari H.
            Nano Today. 2012 Jun 1;7(3):158-167. Epub 2012 May 24.
          • Cationic PAMAM Dendrimers Aggressively Initiate Blood Clot Formation.
            Jones CF, Campbell RA, Brooks AE, Assemi S, Tadjiki S, Thiagarajan G, Mulcock C, Weyrich AS, Brooks BD, Ghandehari H., Grainger DW.
            ACS Nano. 2012 Oct 24. [Epub].
          • Polymeric Conjugates for Drug Delivery.
            Larson N, Ghandehari H.
            Chem Mater. 2012 Mar 13;24(5):840-853. Epub 2012 Jan 4. [PubMed]
          • High Resolution Epifluorescence and TOF-SIMS Chemical Imaging Comparisons of Single DNA
            Microarray Spots.
            Rao AN, Vandencasteele N, Gamble LJ, Grainger DW.
            Anal Chem. 2012 Nov 14. [Epub].
          • Cationic PAMAM Dendrimers Aggressively Initiate Blood Clot Formation.
            Jones CF, Campbell RA, Brooks AE, Assemi S, Tadjiki S, Thiagarajan G, Mulcock C, Weyrich AS, Brooks BD, Ghandehari H, Grainger DW.
            ACS Nano. 2012 Oct 24. [Epub].
          • A Biodegradable Perivascular Wrap for Controlled, Local and Directed Drug Delivery.
            Sanders WG, Hogrebe PC, Grainger DW., Cheung AK, Terry CM.
            J. Control Release. 2012 Jul 10;161(1):81-9 Epub 2012 Apr 27.
          • Comparing Predictive Drug Nephrotoxicity Biomarkers in Kidney 3-D Primary Organoid Culture
            and Immortalized Cell Lines.
            Astashkina AI, Mann BK, Prestwich GD, Grainger DW.
            Biomaterials. 2012 Jun;33(18):4712-21. Epub 2012 Apr 2.
          • A 3-D Organoid Kidney Culture Model Engineered for High-throughput Nephrotoxicity Assays.
            Astashkina AI, Mann BK, Prestwich GD, Grainger DW.
            Biomaterials. 2012 Jun;33(18):4700-11. Epub 2012 Mar 22.
          • A Critical Evaluation of in Vitro Cell Culture Models for High-throughput Drug Screening and
            Toxicity.
            Astashkina A, Mann B, Grainger DW.
            Pharmacol. Ther. 2012 Apr;134(1):82-106. Epub. (2012).
          • RNA Therapeutics Targeting Osteoclast-Mediated Excessive Bone Resorption.
            Wang Y, Grainger DW.
            Adv. Drug Deliv. Rev. 2012 Sep;64(12):1341-57. Epub.
          • Hypoxia-Inducible Plasmid Expressing both miSHP-1 and HO-1 for the Treatment of Ischemic Disease.
            Won YW, Lee M, Kim HA, Bull DA, Kim SW.
            J. Control Release. 2012 Oct 26. doi:pii: S0168-3659(12)00734-1. 10.1016/j.jconrel.2012.10.014. [Epub].
          • Thermosensitive Sol-Gel Reversible Hydrogels.
            Jeong B, Kim SW., Bae YH.
            Adv. Drug Deliv. Rev. 2012 Sep 13. doi:pii: S0169-409X(12)00272-4. 10.1016/j.addr.2012.09.012. [Epub].
          • Polymer-Based Delivery of Glucagon-Like Peptide-1 for the Treatment of Diabetes.
            Kim PH, Kim SW.
            ISRN Endocrinol. 2012;2012:340632. Epub 2012 May 30.
          • In Vivo Delivery of Plasmid DNA into Rabbit Myocardium using Polylysine Copolymers.
            Kim SW.
            Cold Spring Harb Protoc. 2012 May 1;2012(5).
          • In Vitro Transfection with Oligonucleotide DNA using Polylysine Copolymers.
            Kim SW.
            Cold Spring Harb. Protoc. 2012 May 1;2012(5).[PubMed].
          • Dendrimer type Bio-Reducible Polymer for Efficient Gene Delivery.
            Nam HY, Nam K, Lee M, Kim SW., Bull DA.
            J. Control Release. 2012 Jun 28;160(3):592-600. Epub 2012 Apr 23.
          • In Vitro Transfection with Plasmid DNA using Polylysine Copolymers.
            Kim SW.
            Cold Spring Harb Protoc. (4):457-8. 2012 Apr 1.
          • Polylysine Copolymers for Gene Delivery.
            Kim SW.
            Cold Spring Harb Protoc. (4):433-8. 2012 Apr 1.
          • Post-Translational Regulated and Hypoxia-Responsible VEGF Plasmid for Efficient Secretion.
            Won YW, Lee M, Kim HA, Bull DA, Kim SW.
            J. Control Release. 2012 Jun 28;160(3):525-31. 2012 Mar 16. [PubMed].
          • Functional Properties and Biodistribution of Poly(Triethylenetetramine/Cystamine Bisacrylamide) and
            Poly(Triethylenetetramine/Cystamine Bisacrylamide)- Poly(Ethylene Glycol) Mixtures formed with Nucleic Acid.
            Brumbach JH, Lee YW, Kim SW., Yockman JW.
            J. Control Release. 2012 Apr 10;159(1):111-9. Epub. 2012 Jan 20.
          • EphA2 Targeting Peptide Tethered Bioreducible Poly(Cystamine Bisacrylamide-Diamino Hexane)
            for the Delivery of Therapeutic pCMV-RAE-1_ to Pancreatic Islets.
            Blevins KS, Jeong JH, Ou M, Brumbach JH, Kim SW.
            J. Control Release. 2012 Feb 28;158(1):115-22. Epub 2011 Oct 28.
          • Polymer-Drug Conjugates: Origins, Progress to Date and Future Directions.
            Kopeček J.
            Adv. Drug Deliv. Rev. 2012 Nov 2. [Epub].
          • Biological Rationale for the Design of Polymeric Anti-Cancer Nanomedicines.
            Zhou Y, Kopeček J.
            J. Drug Targeting. 2012 Sep 26. [Epub].
          • Smart Self-Assembled Hybrid Hydrogel Biomaterials.
            Kopeček J., Yang J.
            Angew. Chem. Int. Ed. 51, 7396-7417 (2012).
          • Prostate-Cancer-Targeted N-(2-Hydroxypropyl)methacrylamide (HPMA) Copolymer-Docetaxel Conjugates.
            Liu J, Kope_ková P, Pan H, Sima M, Bühler P, Wolf P, Elsässer-Beile U, Kopeček J.
            Macromol. Biosci. 2012 Mar; 12(3):412-22.
          • Hyaluronan Oligomers-HPMA Copolymer Conjugates for Targeting Paclitaxel to CD44-Overexpressing Ovarian Carcinoma.
            Journo-Gershfeld G, Kapp D, Shamay Y, Kopeček J., David A.
            Pharmaceutical Res. 29, 1121-1133 (2012).
          • Biological Activity of Anti-CD20 Multivalent HPMA Copolymer-Fab' Conjugates.
            Johnson RN, Kopečková P, Kopeček J.
            Biomacromolecules 13, 727-735 (2012)
          • Targeting of Multidrug-Resistant Human Ovarian Carcinoma Cells with Anti-P-Glycoprotein Antibody Conjugates.
            Fowers KD, Kopeček J.
            Macromol Biosci. 2012 Apr;12(4):502-14. Epub 2012 Jan 25.
          • Selective Inhibitory Effect of HPMA Copolymer-Cyclopamine Conjugate on Prostate Cancer Stem Cells.
            Zhou Y, Yang J, Kopeček J.
            Biomaterials. 33, 1863-72. (2012).
          • Coiled-Coil Based Drug-Free Macromolecular Therapeutics: In Vivo Efficacy.
            Wu K, Yang J, Liu J, Kopeček J.
            J. Control Release. 157, 126-131 (2012).
          • Design of Polymer-Drug Conjugates.
            J. Kopeček, P. Kopečková
            In: Drug Delivery in Oncology, F. Kratz, P. Senter, H. Steinhagen, Eds., Wiley-VCH, Weinheim,
            Germany,
            2012, Vol. 2, Chapter 17, pp.485-512
          • Targeting Polymer Therapeutics to Bone
            S.A. Low, J. Kopeček.
            Adv. Drug Delivery Rev. 64, 1189-1204 (2012).
          • Anti-CD20 Multivalent HPMA Copolymer-Fab' Conjugates for the Direct Induction of Apoptosis
            T.-W. Chu, J. Yang, J Kopeček.
            Biomaterials 33, 7174-7181 (2012).
          • Targeting malignant Mitochondria with Therapeutic Peptides
            Constance JE, Lim CS.
            Ther. Deliv. 2012 Aug;3(8):961-79. Review. [PubMed].
          • Correction to "Improved Coiled-Coil design Enhances Interaction with bcr-abl and Induces Apoptosis".
            Dixon AS, Miller GD, Bruno BJ, Constance JE, Woessner DW, Fidler TP, Robertson JC, Cheatham TE 3rd, Lim CS.
            Mol. Pharm. 2012 May 7;9(5):1535. Epub 2012 Mar 23.
          • Changing the Subcellular Location of the Oncoprotein Bcr-Abl using Rationally Designed Capture Motifs.
            Dixon AS, Constance JE, Tanaka T, Rabbitts TH, Lim CS.
            Pharm Res. 2012 Apr;29(4):1098-109. Epub 2011 Dec 20.
          • Improved Coiled-Coil Design Enhances Interaction with Bcr-Abl and Induces Apoptosis.
            Dixon AS, Miller GD, Bruno BJ, Constance JE, Woessner DW, Fidler TP, Robertson JC, Cheatham TE 3rd, Lim CS.
            Mol. Pharm. 2012 Jan 1;9(1):187-95. Erratum in: Mol Pharm. 9(5):1535. 2012 May 7.

2011 Publications

          • Cancer nanomedicines targeting tumor extracellular pH. 
            Tian L, Bae YH.
            Colloids Surf B Biointerfaces. 2011 Oct 25.
          • This symposium was specially dedicated to the recognition of Sung Wan Kim (USA) and his vast contributions over his career. Preface.
            Park K, Bae YH, Grainger DW.
            J Control Release. 2011 Oct 30;155(2):113-4. Epub 2011 Sep 2.
          • Apoptosis-targeted drug delivery. 
            Bae YH.
            J Control Release. 2011 Sep 25;154(3):213.
          • Targeted drug delivery to tumors: myths, reality and possibility.
            Bae YH, Park K.
            J Control Release. 2011 Aug 10;153(3):198-205. Epub 2011 Jun 6.
          • Hemoglobin conjugates with antioxidant enzymes (hemoglobin-superoxide dismutase-catalase) via poly(ethylene glycol) crosslinker for protection of pancreatic beta RINm5F cells in hypoxia.
            Nadithe V, Bae YH.
            Tissue Eng Part A. 2011 Oct;17(19-20):2453-62. Epub 2011 Jul 11.
          • The performance of gadolinium diethylene triamine pentaacetate-pullulan hepatocyte-specific T1 contrast agent for MRI.
            Yim H, Yang SG, Jeon YS, Park IS, Kim M, Lee DH, Bae YH, Na K.
            Biomaterials. 2011 Aug;32(22):5187-94. Epub 2011 May 10.
          • Intravital real-time confocal laser scanning imaging of PEGylated gene vectors.
            Bae YH.
            J Control Release. 2011 Apr 30;151(2):103. Epub 2011 Apr 28. Review.
          • Co-delivery of small interfering RNA and plasmid DNA using a polymeric vector incorporating endosomolytic oligomeric sulfonamide.
            Chang Kang H, Bae YH.
            Biomaterials. 2011 Jul;32(21):4914-24. Epub 2011 Apr 12.
          • Albumin-coated porous hollow poly(lactic-co-glycolic acid) microparticles bound with palmityl- acylated exendin-4 as a long-acting inhalation delivery system for the treatment of diabetes.
            Kim H, Lee J, Kim TH, Lee ES, Oh KT, Lee DH, Park ES, Bae YH, Lee KC, Youn YS. Pharm Res.
            2011 Aug;28(8):2008-19. Epub 2011 Apr 7.
          • Reconstitutable charged polymeric (PLGA)(2)-b-PEI micelles for gene therapeutics delivery.
            Mishra D, Kang HC, Bae YH. Biomaterials.
            2011 May;32(15):3845-54. Epub 2011 Feb 26.
          • Prevention of metastasis in a 4T1 murine breast cancer model by doxorubicin carried by folate conjugated pH sensitive polymeric micelles.
            Gao ZG, Tian L, Hu J, Park IS, Bae YH.
            J Control Release. 2011 May 30;152(1):84-9. Epub 2011 Feb 2. 
          • A reducible polycationic gene vector derived from thiolated low molecular weight branched polyethyleneimine linked by 2-iminothiolane.
            Kang HC, Kang HJ, Bae YH.
            Biomaterials. 2011 Feb;32(4):1193-203. Epub 2010 Nov 10.
          • Biodegradable hybrid recombinant block copolymers for non-viral gene transfection.
            Chen TH, Bae Y, Furgeson DY, Kwon GS.
            Int J Pharm. 2011 Oct 1.
          • Biological evaluation of RGDfK-gold nanorod conjugates for prostate cancer treatment.
            Gormley AJ, Malugin A, Ray A, Robinson R, Ghandehari H.
            J Drug Target. 2011 Dec;19(10):915-24.
          • Synthesis and evaluation of poly(styrene-co-maleic acid) micellar nanocarriers for the delivery of tanespimycin.
            Larson N, Greish K, Bauer H, Maeda H, Ghandehari H.
            Int J Pharm. 2011 Nov 25;420(1):111-7. Epub 2011 Aug 12.
          • Fabrication of highly uniform nanoparticles from recombinant silk-elastin-like protein polymers for therapeutic agent delivery.
            Anumolu R, Gustafson JA, Magda JJ, Cappello J, Ghandehari H, Pease LF 3rd.
            ACS Nano. 2011 Jul 26;5(7):5374-82. Epub 2011 Jul 5.
          • Gold nanorod mediated plasmonic photothermal therapy: a tool to enhance macromolecular delivery.
            Gormley AJ, Greish K, Ray A, Robinson R, Gustafson JA, Ghandehari H.
            Int J Pharm. 2011 Aug 30;415(1-2):315-8. Epub 2011 Jun 12.
          • Impact of silica nanoparticle design on cellular toxicity and hemolytic activity.
            Yu T, Malugin A, Ghandehari H.
            ACS Nano. 2011 Jul 26;5(7):5717-28. Epub 2011 Jun 8.
          • Comparison of active and passive targeting of docetaxel for prostate cancer therapy by HPMA copolymer-RGDfK conjugates.
            Ray A, Larson N, Pike DB, Grüner M, Naik S, Bauer H, Malugin A, Greish K, Ghandehari H.
            Mol Pharm. 2011 Aug 1;8(4):1090-9. Epub 2011 Jun 1.
          • Silica nanoconstruct cellular toleration threshold in vitro.
            Herd HL, Malugin A, Ghandehari H.
            J Control Release. 2011 Jul 15;153(1):40-8. Epub 2011 Feb 20.
          • Anticancer and antiangiogenic activity of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer therapy.
            Greish K, Ray A, Bauer H, Larson N, Malugin A, Pike D, Haider M, Ghandehari H.
            J Control Release. 2011 May 10;151(3):263-70. Epub 2011 Jan 9.
          • Comparative biodistribution of PAMAM dendrimers and HPMA copolymers in ovarian-tumor- bearing mice.
            Sadekar S, Ray A, Janàt-Amsbury M, Peterson CM, Ghandehari H.
            Biomacromolecules. 2011 Jan 10;12(1):88-96. Epub 2010 Dec 3. Erratum in: Biomacromolecules. 2011 Sep 12;12(9):3351.
          • G3.5 PAMAM dendrimers enhance transepithelial transport of SN38 while minimizing gastrointestinal toxicity.
            Goldberg DS, Vijayalakshmi N, Swaan PW, Ghandehari H.
            J Control Release. 2011 Mar 30;150(3):318-25. Epub 2010 Nov 27.
          • Geometry and surface characteristics of gold nanoparticles influence their biodistribution and uptake by macrophages.
            Arnida, Janát-Amsbury MM, Ray A, Peterson CM, Ghandehari H.
            Eur J Pharm Biopharm. 2011 Apr;77(3):417-23. Epub 2010 Nov 18.
          • Kinetic analysis of the interaction between poly(amidoamine) dendrimers and model lipid membranes.
            Tiriveedhi V, Kitchens KM, Nevels KJ, Ghandehari H, Butko P.
            Biochim Biophys Acta. 2011 Jan;1808(1):209-18. Epub 2010 Sep 7.
          • RNA therapeutics targeting osteoclast-mediated excessive bone resorption.
            Wang Y, Grainger DW.
            Adv Drug Deliv Rev. 2011 Sep 10.
          • This symposium was specially dedicated to the recognition of Sung Wan Kim (USA) and his vast contributions over his career. Preface.
            Park K, Bae YH, Grainger DW.
            J Control Release. 2011 Oct 30;155(2):113-4. Epub 2011 Sep 2.
          • Cultured Primary Macrophage Activation by Lipopolysaccharide Depends on Adsorbed Protein Composition and Substrate Surface Chemistry.
            Diekjürgen D, Astashkina A, Grainger DW, Holt D, Brooks AE.
            J Biomater Sci Polym Ed. 2011 Jun 28.
          • Evaluating antibiotic release profiles as a function of polymer coating formulation - biomed 2011.
            Davidoff SN, Sevy JO, Brooks BD, Grainger DW, Brooks AE.
            Biomed Sci Instrum. 2011;47:46-51.
          • Comparison of Bi(1), Bi(3) and C(60) primary ion sources for ToF-SIMS imaging of patterned protein samples.
            Dubey M, Brison J, Grainger DW, Castner DG.
            Surf Interface Anal. 2011 Jan;43(1-2):261-264. 
          • Multinucleated giant cells from fibroblast cultures.
            Holt DJ, Grainger DW.
            Biomaterials. 2011 Jun;32(16):3977-87.
          • Macrophage response to staphylococcal biofilms on crosslinked poly(ethylene) glycol polymer coatings and common biomaterials in vitro.
            Saldarriaga Fernández IC, Da Silva Domingues JF, van Kooten TG, Metzger S, Grainger DW, Busscher HJ, van der Mei HC.
            Eur Cell Mater. 2011 Jan 14;21:73-9; discussion 79.
          • Small interfering RNA knocks down the molecular target of alendronate, farnesyl pyrophosphate synthase, in osteoclast and osteoblast cultures.
            Wang Y, Panasiuk A, Grainger DW.
            Mol Pharm. 2011 Aug 1;8(4):1016-24. Epub 2011 Jan 21.
          • Competitive time- and density-dependent adhesion of staphylococci and osteoblasts on crosslinked poly(ethylene glycol)-based polymer coatings in co-culture flow chambers.
            Saldarriaga Fernández IC, Busscher HJ, Metzger SW, Grainger DW, van der Mei HC.
            Biomaterials. 2011 Feb;32(4):979-84. Epub 2010 Oct 27.
          • Clinical analysis of hemodialysis vascular access: comparision of autogenous arterioveonus fistula & arteriovenous prosthetic graft.
            Kim DS, Kim SW, Kim JC, Cho JH, Kong JH, Park CR.
            Korean J Thorac Cardiovasc Surg. 2011 Feb;44(1):25-31. Epub 2011 Feb 12.
          • Evolution of oncolytic adenovirus for cancer treatment.
            Choi JW, Lee JS, Kim SW, Yun CO.
            Adv Drug Deliv Rev. 2011 Dec 24.
          • The effect of allergic rhinitis on the degree of stress, fatigue and quality of life in OSA patients.
            Park CE, Shin SY, Lee KH, Cho JS, Kim SW.
            Eur Arch Otorhinolaryngol. 2011 Dec 30.
          • Linearized oncolytic adenoviral plasmid DNA delivered by bioreducible polymers.
            Kim J, Kim PH, Nam HY, Lee JS, Yun CO, Kim SW.
            J Control Release. 2011 Dec 20.
          • Antidepressant prescribing patterns in Korea: results from the clinical research center for depression study.
            Bae KY, Kim SW, Kim JM, Shin IS, Yoon JS, Jung SW, Lee MS, Yim HW, Jun TY.
            Psychiatry Investig. 2011 Sep;8(3):234-44. Epub 2011 Aug 26.
          • Polymeric gene delivery for diabetic treatment.
            Kim SW. Diabetes Metab J.
            2011 Aug;35(4):317-26. Epub 2011 Aug 31.
          • Bioreducible polymer-conjugated oncolytic adenovirus for hepatoma-specific therapy via systemic administration.
            Kim PH, Kim J, Kim TI, Nam HY, Yockman JW, Kim M, Kim SW, Yun CO.
            Biomaterials. 2011 Dec;32(35):9328-42. Epub 2011 Sep 16.
          • Associations of serotonergic genes with poststroke emotional incontinence.
            Kim JM, Stewart R, Kang HJ, Bae KY, Kim SW, Shin IS, Kim JT, Park MS, Cho KH, Yoon JS.
            Int J Geriatr Psychiatry. 2011 Sep 13. doi: 10.1002/gps.2787.
          • Synergistic associations of depression and apolipoprotein E genotype with incidence of dementia.
            Kim JM, Stewart R, Kim SY, Kim SW, Bae KY, Yang SJ, Shin IS, Yoon JS.
            Int J Geriatr Psychiatry. 2011 Sep;26(9):893-8. doi: 10.1002/gps.2621. Epub 2010 Oct 29.
          • Associations of cytokine gene polymorphisms with post-stroke depression.
            Kim JM, Stewart R, Kim SW, Shin IS, Kim JT, Park MS, Park SW, Kim YH, Cho KH, Yoon JS.
            World J Biol Psychiatry. 2011 Jul 27.
          • Cephalometric Predictors of Therapeutic Response to Multilevel Surgery in Patients With Obstructive Sleep Apnea.
            Kim SJ, Kim YS, Park JH, Kim SW.
          • Relationship between a hopeful attitude and cellular immunity in patients with breast cancer.
            Kim SW, Kim SY, Kim JM, Park MH, Yoon JH, Shin MG, Na HS, Bae KY, Shin IS, Yoon JS.
            Gen Hosp Psychiatry. 2011 Jul-Aug;33(4):371-6. Epub 2011 May 20.
          • Relationship between a history of a suicide attempt and treatment outcomes in patients with depression.
            Kim SW, Stewart R, Kim JM, Shin IS, Yoon JS, Jung SW, Lee MS, Yim HW, Jun TY.
            J Clin Psychopharmacol. 2011 Aug;31(4):449-56.
          • Gustatory function after radiofrequency tongue base reduction in patients with obstructive sleep apnea.
            Eun YG, Shin SY, Byun JY, Kim MG, Lee KH, Kim SW.
            Otolaryngol Head Neck Surg. 2011 Nov;145(5):853-7. Epub 2011 Jun 20.
          • Association of grip strength with dementia in a Korean older population.
            Shin HY, Kim SW, Kim JM, Shin IS, Yoon JS.
            Int J Geriatr Psychiatry. 2011 May 27. doi: 10.1002/gps.2742.
          • Stressful events, stress perception and treatment outcomes in patients with depressive disorders: the CRESCEND study.
            Kim JM, Kim SW, Stewart R, Kang HJ, Shin IS, Jung SW, Lee MS, Yim HW, Jun TY.
            J Affect Disord. 2011 Oct;133(3):528-36. Epub 2011 May 28.
          • Synthesis, Characteristics and Potential Application of Poly(β-Amino Ester Urethane)-Based Multiblock Co-Polymers as an Injectable, Biodegradable and pH/Temperature-Sensitive Hydrogel System.
            Huynh CT, Nguyen MK, Jeong IK, Kim SW, Lee DS.
            J Biomater Sci Polym Ed. 2011 May 27. Active targeting of RGD-conjugated bioreducible polymer for delivery of oncolytic adenovirus expressing shRNA against IL-8 mRNA. Kim J, Nam HY, Kim TI, Kim PH, Ryu J, Yun CO, Kim SW. Biomaterials. 2011 Aug;32(22):5158-66. Epub 2011 Apr 30.
          • Bioreducible polymers for gene delivery.
            Kim TI, Kim SW.
            React Funct Polym. 2011 Mar 1;71(3):344-349.
          • Cell penetrating peptide conjugated bioreducible polymer for siRNA delivery.
            Nam HY, Kim J, Kim S, Yockman JW, Kim SW, Bull DA.
            Biomaterials. 2011 Aug;32(22):5213-22. Epub 2011 Apr 17.
          • Changes of Alpha1-Antitrypsin Levels in Allergen-induced Nasal Inflammation.
            Shin SY, Choi GS, Lee KH, Kim SW, Won KY, Lee JH, Cho JS, Park HS.
            Clin Exp Otorhinolaryngol. 2011 Mar;4(1):33-9. Epub 2011 Mar 17.
          • Biomaterials to gene delivery.
            Kim SW.
            J Control Release. 2011 Oct 30;155(2):116-8. Epub 2011 Mar 30.
          • PEI-g-PEG-RGD/small interference RNA polyplex-mediated silencing of vascular endothelial growth factor receptor and its potential as an anti-angiogenic tumor therapeutic strategy.
            Kim J, Kim SW, Kim WJ.
            Oligonucleotides. 2011 Mar-Apr;21(2):101-7. Epub 2011 Mar 4.
          • Bioreducible polymers with cell penetrating and endosome buffering functionality for gene delivery systems.
            Kim TI, Rothmund T, Kissel T, Kim SW.
            J Control Release. 2011 May 30;152(1):110-9. Epub 2011 Feb 23.
          • Predictors of 12-week remission in a nationwide cohort of people with depressive disorders: the CRESCEND study.
            Kim JM, Kim SW, Stewart R, Kim SY, Yoon JS, Jung SW, Lee MS, Yim HW, Jun TY.
            Hum Psychopharmacol. 2011 Feb 23. doi: 10.1002/hup.1168.
          • Active targeting and safety profile of PEG-modified adenovirus conjugated with herceptin. Kim PH, Sohn JH, Choi JW, Jung Y, Kim SW, Haam S, Yun CO. Biomaterials. 2011 Mar;32(9):2314-26. Epub 2011 Jan 11.
          • Synthesis, Characteristics and Potential Application of Poly(β-Amino Ester Urethane)-Based Multiblock Co-Polymers as an Injectable, Biodegradable and pH/Temperature-Sensitive Hydrogel System.
            Huynh CT, Nguyen MK, Jeong IK, Kim SW, Lee DS.
            J Biomater Sci Polym Ed. 2011 May 27.
          • Bioreducible polymer-transfected skeletal myoblasts for VEGF delivery to acutely ischemic myocardium.
            McGinn AN, Nam HY, Ou M, Hu N, Straub CM, Yockman JW, Bull DA, Kim SW.
            Biomaterials. 2011 Jan;32(3):942-9. Epub 2010 Nov 5.
          • Synthesis and characterization of poly(ε-caprolactone)-block-poly[N-(2- hydroxypropyl)methacrylamide] micelles for drug delivery.
            Krimmer SG, Pan H, Liu J, Yang J, Kopeček J.
            Macromol Biosci. 2011 Aug 11;11(8):1041-51. doi: 10.1002/mabi.201100019. Epub 2011 May 12.
          • Biodegradable Multiblock Poly[N-(2-hydroxypropyl)methacrylamide] via Reversible Addition- Fragmentation Chain Transfer Polymerization and Click Chemistry.
            Luo K, Yang J, Kopečková P, Kopeček J.
            Macromolecules. 2011 Apr 26;44(8):2481-2488.
          • Hybrid hydrogels self-assembled from graft copolymers containing complementary β-sheets as hydroxyapatite nucleation scaffolds.
            Wu LC, Yang J, Kopeček J.
            Biomaterials. 2011 Aug;32(23):5341-53. Epub 2011 May 5.
          • Synthesis of Biodegradable Multiblock Copolymers by Click Coupling of RAFT-Generated HeterotelechelicPolyHPMA Conjugates.
            Yang J, Luo K, Pan H, Kopečková P, Kopeček J.
            React Funct Polym. 2011 Mar 1;71(3):294-302.
          • Enhanced anti-tumor activity and safety profile of targeted nano-scaled HPMA copolymer- alendronate-TNP-470 conjugate in the treatment of bone malignances.
            Segal E, Pan H, Benayoun L, Kopečková P, Shaked Y, Kopeček J, Satchi-Fainaro R.
            Biomaterials. 2011 Jul;32(19):4450-63. Epub 2011 Mar 22.
          • Backbone degradable multiblock N-(2-hydroxypropyl)methacrylamide copolymer conjugates via reversible addition-fragmentation chain transfer polymerization and thiol-ene coupling reaction.
            Pan H, Yang J, Kopecková P, Kopecek J.
            Biomacromolecules. 2011 Jan 10;12(1):247-52. Epub 2010 Dec 15.
          • Study of the therapeutic benefit of cationic copolymer administration to vascular endothelium under mechanical stress.
            Giantsos-Adams K, Lopez-Quintero V, Kopeckova P, Kopecek J, Tarbell JM, Dull R.
            Biomaterials. 2011 Jan;32(1):288-94. Epub 2010 Oct 6.
          • Development of an effective therapy for chronic myelogenous leukemia.
            Woessner DW, Lim CS, Deininger MW.
            Cancer J. 2011 Nov-Dec;17(6):477-86.
          • Improved coiled-coil design enhances interaction with Bcr-Abl and induces apoptosis.
            Dixon AS, Miller GD, Bruno BJ, Constance JE, Woessner DW, Fidler TP, Robertson JC, Cheatham TE, Lim CS.
            Mol Pharm. 2012 Jan 1;9(1):187-95. Epub 2011 Dec 12.
          • The androgen receptor and its use in biological assays: looking toward effect-based testing and its applications.
            Cadwallader AB, Lim CS, Rollins DE, Botrè F.
            J Anal Toxicol. 2011 Nov;35(9):594-607.
          • Pten is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB- cytokine network.
            Ying H, Elpek KG, Vinjamoori A, Zimmerman SM, Chu GC, Yan H, Fletcher-Sananikone E, Zhang H, Liu Y, Wang W, Ren X, Zheng H, Kimmelman AC, Paik JH, Lim C, Perry SR, Jiang S, Malinn B, Protopopov A, Colla S, Xiao Y, Hezel AF, Bardeesy N, Turley SJ, Wang YA, Chin L, Thayer SP, Depinho RA.
            Cancer Discov. 2011 Jul 1;1(2):158-169.
          • Disruption of Bcr-Abl coiled coil oligomerization by design.
            Dixon AS, Pendley SS, Bruno BJ, Woessner DW, Shimpi AA, Cheatham TE 3rd, Lim CS.
            J Biol Chem. 2011 Aug 5;286(31):27751-60. Epub 2011 Jun 9.
          • Clinical validation of cutoff target ranges in newborn screening of metabolic disorders by tandem mass spectrometry: a worldwide collaborative project.
            McHugh DM, Cameron CA, Abdenur JE, Abdulrahman M, Adair O, Al Nuaimi SA, Åhlman H, Allen JJ, Antonozzi I, Archer S, Au S, Auray-Blais C, Baker M, Bamforth F, Beckmann K, Pino GB, Berberich SL, Binard R, Boemer F, Bonham J, Breen NN, Bryant SC, Caggana M, Caldwell SG, Camilot M, Campbell C, Carducci C, Bryant SC, Caggana M, Caldwell SG, Camilot M, Campbell C, Carducci C, Cariappa R, Carlisle C, Caruso U, Cassanello M, Castilla AM, Ramos DE, Chakraborty P, Chandrasekar R, Ramos AC, Cheillan D, Chien YH, Childs TA, Chrastina P, Sica YC, de Juan JA, Colandre ME, Espinoza VC, Corso G, Currier R, Cyr D, Czuczy N, D'Apolito O, Davis T, de Sain-Van der Velden MG, Delgado Pecellin C, Di Gangi IM, Di Stefano CM, Dotsikas Y, Downing M, Downs SM, Dy B, Dymerski M, Rueda I, Elvers B, Eaton R, Eckerd BM, El Mougy F, Eroh S, Espada M, Evans C, Fawbush S, Fijolek KF, Fisher L, Franzson L, Frazier DM, Garcia LR, Bermejo MS, Gavrilov D, Gerace R, Giordano G, Irazabal YG, Greed LC, Grier R, Grycki E, Gu X, Gulamali-Majid F, Hagar AF, Han L, Hannon WH, Haslip C, Hassan FA, He M, Hietala A, Himstedt L, Hoffman GL, Hoffman W, Hoggatt P, Hopkins PV, Hougaard DM, Hughes K, Hunt PR, Hwu WL, Hynes J, Ibarra-González I, Ingham CA, Ivanova M, Jacox WB, John C, Johnson JP, Jónsson JJ, Karg E, Kasper D, Klopper B, Katakouzinos D, Khneisser I, Knoll D, Kobayashi H, Koneski R, Kozich V, Kouapei R, Kohlmueller D, Kremensky I, la Marca G, Lavochkin M, Lee SY, Lehotay DC, Lemes A, Lepage J, Lesko B, Lewis B, Lim C, Linard S, Lindner M, Lloyd-Puryear MA, Lorey F, Loukas YL, Luedtke J, Maffitt N, Magee JF, Manning A, Manos S, Marie S, Hadachi SM, Marquardt G, Martin SJ, Matern D, Mayfield Gibson SK, Mayne P, McCallister TD, McCann M, McClure J, McGill JJ, McKeever CD, McNeilly B, Morrissey MA, Moutsatsou P, Mulcahy EA, Nikoloudis D, Norgaard-Pedersen B, Oglesbee D, Oltarzewski M, Ombrone D, Ojodu J, Papakonstantinou V, Reoyo SP, Park HD, Pasquali M, Pasquini E, Patel P, Pass KA, Peterson C, Pettersen RD, Pitt JJ, Poh S, Pollak A, Porter C, Poston PA, Price RW, Queijo C, Quesada J, Randell E, Ranieri E, Raymond K, Reddic JE, Reuben A, Ricciardi C, Rinaldo P, Rivera JD, Roberts A, Rocha H, Roche G, Greenberg CR, Mellado JM, Juan-Fita MJ, Ruiz C, Ruoppolo M, Rutledge SL, Ryu E, Saban C, Sahai I, García-Blanco MI, Santiago-Borrero P, Schenone A, Schoos R, Schweitzer B, Scott P, Seashore MR, Seeterlin MA, Sesser DE, Sevier DW, Shone SM, Sinclair G, Skrinska VA, Stanley EL, Strovel ET, Jones AL, Sunny S, Takats Z, Tanyalcin T, Teofoli F, Thompson JR, Tomashitis K, Domingos MT, Torres J, Torres R, Tortorelli S, Turi S, Turner K, Tzanakos N, Valiente AG, Vallance H, Vela-Amieva M, Vilarinho L, von Döbeln U, Vincent MF, Vorster BC, Watson MS, Webster D, Weiss S, Wilcken B, Wiley V, Williams SK, Willis SA, Woontner M, Wright K, Yahyaoui R, Yamaguchi S, Yssel M, Zakowicz WM.
            Genet Med. 2011 Mar;13(3):230-54.
          • Specific and modular binding code for cytosine recognition in Pumilio/FBF (PUF) RNA-binding domains.
            Dong S, Wang Y, Cassidy-Amstutz C, Lu G, Bigler R, Jezyk MR, Li C, Hall TM, Wang Z.
            J Biol Chem. 2011 Jul 29;286(30):26732-42. Epub 2011 Jun 8.

2010 Publications

          • J.H. Maeng, D.H. Lee, K.H. Jung, Y.H. Bae, I.S. Park, S. Jeong, Y.S. Jeon, C.K. Shim, W. Kim, J. Kim, J. Lee, Y.M. Lee, J.H. Kim, W.H. Kim, S.S. Hong. "Multifunctional doxorubicin loaded superparamagnetic iron oxide nanoparticles for chemotherapy and magnetic resonance imaging in liver cancer", Biomaterials. 2010 (18): 4995-5006.
          • H.C. Kang, O. Samsonova, Y.H. Bae. "Trafficking microenvironmental pHs of polycationic gene vectors in drug-sensitive and multidrug-resistant MCF7 breast cancer cells", Biomaterials. 2010 31(11): 3071-8
          • R.B. Paulsen, P.P. Seth, E.E. Swayze, R.H. Griffey, J.J. Akalicky, T.E. Cheatham III, D.R. Davis. "Inhibitor-induced structural change in the HCV IRES domain IIa RNA", Proc Natl Acad Sci USA 2010 107(16): 7263-8.
          • R. Lavery, K. Zakrzewska, D. Beveridge, T.C. Bishop, D.A. Case, T.E. Cheatham III, S. Dixit, B. Jayaram, F. Lankas, C. Laughton, J.H. Maddocks, A. Michon, R. OSman, M. Orozco, A. Perez, T. Singh, N. Spackova, J. Sponer. "A systematic molecular dynamics study of nearest-neighbor effects on base pair and base pair step confomations and fluctuations in B-DNA", 2010 (1): 299-313.
          • H. Freedman, L.P. Huynh, L. Le, T.E. Cheatham III, J.A. Tuszynski, T.N. Truong. "Explicitly solvated ligand contribution to continuum solvation models for binding free energies: selectivity of theophylline binding to an RNA aptamer", J Phys Chem B. 2010 114(6): 2227-37.
          • G. Thiagarajan, A. Ray, A. Malugin, H. Ghandehari. "PAMAM-Camptothecin Conjugate Inhibits Proliferation and Induces Nuclear Fragmentation in Colorectal Carcinoma Cells", Pharm REs. 2010 (in press).
          • J.A. Gustafson, H. Ghandehari. "Silk-elastinlike protein polymers for matrix-mediated cancer gene therapy", Adv Drug Deliv Rev. 2010 (in press).
          • D.S. Goldberg, H. Ghandehari, P.W. Swaan. "Cellular Entry of G3.5 Poly (amino amine) Dendrimers by Clathrin- and Dynamin-Dependent Endocytosis Promotes Tight Junctional Opening in Intestinal Epithelia", Pharm Res. 2010 (in press).
          • D.B. Pike, H. Ghandehari. "HPMA copolymer-cyclic RGD conjugates for tumor targeting", Adv Drug Deliv Rev. 2010 Feb 17;62(2): 167-83.
          • Arnida, A. Malugin, H. Ghandehari. "Cellular uptake and toxicity of gold nanoparticles in prostate cancer cells: a comparative study of rods and spheres", J appl Toxicol. 2010 (3): 212-7.
          • I.C. Saldarriaga Fernández, H.C. Mei, S. Metzger, D.W. Grainger, A.F. Engelsman, M.R. Nejadnik, H.J. Buscher. "In vitro and in vivo comparisons of staphylococcal biofilm formation on a cross linked poly(ethylene glycol) -based polymer coating". Acta. Biomater. 6(3): 1119-24. (2010).
          • F. Liu, M. Dubey, H. Takahashi, D.G. Castner, D.W. Grainger. "Immobilized Antibody Orientation Analysis using Secondary Ion Mass Spectrometry and Fluorescence Imaging of Affinity-generated Patterns", Anal. Chem., 82, (2010).
          • Y. Wang, D.W. Grainger. "siRNA knock-down of RANK signaling to control osteoclast-mediated bone resorption", Pharm. Res., 27(7) (2010), 1273-1279, doi 10.1007/s11095-010-0099-5 (2010).
          • M. Dubey, J. Brison, D.W. Grainger, D.G. Castner. "Comparison of Bi1=, Bi3+, and C60+ primary ion sources for ToF-SIMS imaging of patterned protein samples", Surf. Interface Anal., 42 (2010).
          • J.L. Steimer, S.G. Dahl, D.P. De Alwis, U. Gundert-Remy, M.O. Karlsson, J. Martinkova, L. Aarons, H.J. Ahr, J. Clairambault, G. Freyer, L.E. Friberg, S.E. Kern, A. KoppSchneider, W.D. Ludwig, G. De Nicolao, M. Rocchetti, I.F. Troconiz. "Modelling the genesis and treatment of cancer: the potential role of physiologically based pharmacodynamics", Eur J Cancer. 2010 46(1): 21-32.
          • J. Yang, M.T. Jacobsen, H. Pan, J. Kopecek. "Synthesis and characterization of enzymatically degradable PEG-based peptide-containing hydrogels", Macromol Biosci. 2010 10(4): 445-54.
          • J. Liu, H. Bauer, J. Callahan, P. Kopeckov, H. Pan, J. Kopecek. "Endocytic uptake of a large array of HPMA copolymers: Elucidation into the dependence on the physicochemical characteristics", 2010 143(1): 71-9.
          • J. Kopecek, P. Kopeckov. "HPMA copolymers: origins, early developments, present, and future", Adv Drug Deliv Rev. 2010 62(2): 122-49.
          • K. Wu, J. Liu, R.N. Johnson, J. Yang, J. Kopeček, "Drug-Free Macromolecular Therapeutics: Induction of Apoptosis by Coiled-Coil Mediated Crosslinking of Antigens on Cell Surface", Angew. Chem. Int. Ed., 49, 1451-1455 (2010).
          • A.B. Cadwallader, D.E. Rollins, C.S. Lim. "Effect of anabolic-androgenic steroids and glucocorticoids on the kinetics of hAR and hGR nucleocytoplasmic translocation", Mol Pharm. 2010 Jun 7; 7(3): 689-98.

2009 Publications

          • V. Nadithe, Y.H. Bae, "Low p50 hemoglobin conjugated with antioxidant enzymes via poly (ethylene glycol) cross-linker (Hb-SOD-CAT) for protection of isolated cells in hypoxia". Biomacromol (submitted)
          • V. Nadithe, Y.H. Bae, "Synthesis and characterization of hemoglobin conjugates with antioxidant enzymes via poly(ethylene oxide) crosslinker (Hb-SOD-CAT) for protection from free radical stress", Biomacromol (submitted) 
          • H. Yin, S.-W. Kang, Y.H. Bae*, "Polymersome formation from AB2 type 3-miktoarm star copolymers", Macromolecules, 2009, 42(19), 7456-7464.
          • D. Kim, Z. Gao, E.S. Lee, Y.H. Bae*, "In vivo evaluation of doxorubicin loaded polymeric micelle targeting folate receptor and early endosomal pH with drug resistant ovarian cancer", Mol. Pharm. 2009, 6(5), 1353-1362.  
          • S.-W. Kang and Y.H. Bae*, "Cryopreservable and tumorigenic three dimensional tumor culture in porous poly(lactic-co-glycolic acid) microsphere", Biomaterials 2009, 30, 4227-4232.
          • H.C. Kang, Y.H. Bae*, "Transfection of rat pancreatic islet tissue by polymeric gene vectors", Diab. Tech. & Thera. 2009, 11, 443-449.
          • H.C. Kang, Y.H. Bae*, "Transfection of insulin-secreting cell line and rat islets by functional polymeric gene vector", Biomaterials, 2009, 30, 2837-2845.
          • K.M. Park, H.C. Kang, J.K. Cho, I.-J. Chung, S.-H. Cho, Y.H. Bae, and K. Na*, "All-trans-retinoic acid (ATRA)-grafted polymeric gene carriers for nuclear translocation and cell growth control", Biomaterials 2009, 30, 2642-2652
          • Y.H. Bae*, "Drug targeting and tumor heterogeneity (perspective)", J. Control. Rel., 2009, 133, 2-3.
          • H. Yin, Y.H. Bae*, "Physicochemical aspects of doxorubicin-loaded pH-sensitive polymeric micelle formulations", Eur. J. Pharm. Biopharm. 2009, 71, 223-230.
          • D. Kim, Y.H. Bae, "Polymeric carriers for anticancer drugs",  in Yi Lu, Ram I. Mahato (Eds.), Pharmaceutical Perspectives of Cancer Therapeutics, Springer, New York, USA. 2009, pp.207-244.
          • Y.S. Youn, K.C. Lee, Y.H. Bae, K. Na, E.S. Lee, "Advanced pulmonary delivery of peptides or proteins using polymeric particles", in L. Jorgenson and H. M. Nielson (Eds.), Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines, Wiley & Sons, Ltd., West Sussex, United Kingdom, 2009, pp.227-244.
          • R. Lavery, K. Zakrzewska, D.L. Beveridge, T.C. Bishop, D.A. Case, T.E. Cheatham, III, S. Dixit, B. Jayaram, F. Lankas, C. Laughton, J.H. Maddocks, A. Michon, R. Osman, M. Orozco, A. Perez, T. Singh, N. Spackova, and J. Sponer.  "A systematic molecular dynamics study of nearest-neighbor effects on base pair and base pair step conformations and fluctuations in B-DNA".  Nuc. Acids Res. (2009) [In press].
          • E. Fadrna, N. Spackova, J. Sarzynska, J. Koca, M. Orozco, T.E. Cheatham, III, T. Kulinski, J. Sponer. "Single stranded loops of quadruplex DNA as key benchmark for testing nucleic acids force field"  J. Chem. Theory Comp.  5, 2514-2530 (2009).
          • In Suk Joung, and T.E. Cheatham, III.  "Molecular dynamics simulations of the dynamic and energetic properties of alkali and halide ions using water-model specific ion parameters."  J. Phys. Chem. B 113, 13279-13290 (2009).
          • In Suk Joung, Ö Persil Çetinkol, N. V. Hud, and T.E. Cheatham, III. "Molecular dynamics simulations and coupled nucleotide substitution experiments indicate the nature of A A base pairing and a putative structure of the coralyne-induced homo-adenine duplex."  Nuc. Acids Res. 37, 7715-7727 (2009).
          • T. S. Han, M.-M. Zhang, A. Walewska, P. Gruszczynski, C.R. Robertson, T.E. Cheatham, III, D. Yoshikami, B. M. Olivera, and G. Bulaj. "Structurally-minimized μ-conotoxin analogs as sodium channel blockers: Implications for designing conopeptide-based therapeutics."  Chem. Med. Chem. 4, 406-414 (2009).
          • H. Wang, T.E. Cheatham, III, P.M. Gannett, and J. Lewis. "Differential electronic states observed during the A-B DNA duplex conformational transitions."  Soft Matter  5, 685-690 (2009).
          • S. S. Pendley, Y. B. Yu, and T.E. Cheatham, III.  "Molecular dynamics guided study of salt bridge length dependence in both fluorinated and non-fluorinated parallel dimeric coiled-coil proteins."  Proteins  74, 612-629 (2009) [DOI: 10.1002/prot.22177].
          • O Bar-Ilan, RA Albrecht, VE Fako, and DY Furgeson.  Toxicity assessments of multi-sized gold and silver nanoparticles in zebrafish embryos.  Small (2009) 5(16):1897-1910.
          • VE Fako and DY Furgeson.  Assessing biomaterial nanotoxicity with a novel zebrafish model.  (2009) Adv Drug Del Rev (2009) 61(6):478-486.
          • K. Kitchens, and H. Ghandehari, "PAMAM Dendrimers as Nanoscale Oral Drug Delivery Systems", in Nanotechnology in Drug Delivery, M.M. deVilliers, P. Aramwit, and G.S. Kwon (Eds), Springer Science, New York, NY, pp. 423-459 (2009)
          • R. Dandu, A. V. Cresce, R. Briber, P. Dowell, J. Cappello, H. Ghandehari, "Silk-elastinlike Protein Polymer Hydrogels: Influence of Monomer Sequence on Physicochemical Properties", Polymer, 50: 366-374 (2009)
          • D. Hwang, V. Moolchandani, R. Dandu, M. Haider, J. Cappello, and H. Ghandehari, "Influence of Polymer Structure and Biodegradation on DNA Release from Silk-Elastinlike Protein Polymer Hydrogels", International Journal of Pharmaceutics, 368: 215-219 (2009)
          • D.M. Sweet, R.B. Kolhatkar, P. Swaan, and H. Ghandehari, "Transepithelial Transport of PEGylated Anionic Poly (amido amine) Dendrimers: Implications for Oral Drug Delivery", J Controlled Release, 138: 78-85 (2009)
          • B. Zarabi, M.P. Borgman, J. Zhuo, R. Gullapalli, and H. Ghandehari, "Noninvasive Monitoring of HPMA Copolymer-RGDfK Conjugates by Magnetic Resonance Imaging", Pharmaceutical Research, 26: 1121-1129 (2009)
          • M.P. Borgman, A. Ray, R.B. Kolhatkar, E.A. Sausville, A.M. Burger, and H. Ghandehari, "Targetable HPMA Copolymer-Aminohexylgeldanamycin Conjugates for Prostate Cancer Therapy", Pharmaceutical Research, 26: 1407-1418 (2009)
          • A. Hatefi and H. Ghandehari, "Recombinant Polymers: Promise for Gene Therapy", Controlled Release Society Newsletter, 26(2): 16-18(2009)
          • K. Greish, K. Araki, D. Li, B.W. O'Malley Jr., R. Dandu, J. Frandsen, J. Cappello, and H. Ghandehari, "Silk-Elastinlike Protein Polymer Hydrogels for Localized Adenoviral Gene Therapy of Head and Neck Tumors", Biomacromolecules, 10: 2183-2188 (2009)
          • W. Hwang, B-H. Kim, R. Dandu, J. Cappello, H. Ghandehari, and J. Seog, "Surface Induced Nanofiber Growth by Self-Assembly of a Silk-Elastinlike Protein Polymer", Langmuir, 25: 12682-12686 (2009)
          • J. Gustafson, K. Greish, J. Frandsen, J. Cappello, and H. Ghandehari, "Silk-Elastinlike Recombinant Polymers for Gene Therapy of Head and neck Cancer: From Molecular Definition to Controlled Gene Expression", J. Controlled Release,  doi:10.1016/j.jconrel.2009.05.022 [Epub ahead of print]
          • Arnida, A. Malugin, and H. Ghandehari, "Cellular Uptake and Toxicity of Gold Nanoparticles in Prostate Cancer Cells: A Comparative Study of Rods and Spheres", Journal of Applied Toxicology, DOI: 10.1002/jat.1486 [Epub ahead of print]
          • M.P. Borgman, O. Aras, S. Geyser-Stoops, E.A. Sausville, and H. Ghandehari, "Biodistribution of HPMA Copolymer-Aminohexylgeldanamycin-RGDfK Conjugates for Prostate Cancer Drug Delivery", Molecular Pharmaceutics, DOI: 10.1021/mp900134c [Epub ahead of print]
          • R. J. Christie, C. Tadiello, D. W. Grainger, "Preparation and Optical Properties of a Novel Thiol-Derivatized Tetramethylrhodamine Dye", Bioconj. Chem., 20(3), 476-480 (2009); doi: 10.1021/bc800367e
          • C. Jones and D.W. Grainger, "In vitro assays and experimental models of nanomaterial toxicity", Adv. Drug Del. Rev., 61 438-456; doi:10.1016/j.addr.2009.03.005, 2009.
          • D.W. Grainger, "Nanotoxicity and nanomaterials: large concerns or small talk?", Adv. Drug Deliv. Rev. 61 419-421 (2009), doi:10.1016/j.addr.2009.04.003.
          • M. Dubey, K. Emoto, F. Cheng, L.J. Gamble, H. Takahashi, D.W. Grainger, D.G. Castner, "Surface Analysis of Photolithographic Patterns using ToF-SIMS and PCA", Surf. Interfacial Anal., doi 10.1002/sia.3056, published on-line, February, 2009; 41: 645 652 (2009).
          • D.M. Higgins, R.J. Basaraba, A. Hohnbaum, D.W. Grainger, M. Gonzalez-Juarrero, "Spatial Relationships of Immune Modulators in the Foreign Body Response", Am. J. Pathol., 175: 161-170 (2009).
          • M. Dubey, K. Emoto, H. Takahashi, D.G. Castner, D. W. Grainger, "Affinity-based Protein Surface Pattern Formation by Ligand Self-Selection from Mixed Protein Solutions", Adv. Funct. Mater., 19, 3046 3055 (2009); DOI: 10.1002/adfm.200900809.
          • D.W. Grainger, "Engaging in quality technical peer review as an international professional responsibility; those who publish confidently must also review competently", Revista Ingeniria Biomedica, 3(5) 66-73 (2009). (both English and Spanish full translation)
          • D.W. Grainger, "DNA nanotechnology: geometric sorting boards", News and Views, Nature Nanotechnology, doi:10.1038/nnano.2009.249, 4:543-544 (2009).
          • Christensen, D. A. and J. N. Herron, "Optical System Design for Biosensors Based on CCD Detection. In: Biosensors and Protocols, Volume 1: Optical-Based Detectors (Rasooly, A. and Herold, K. E., eds.). Series": Methods in Molecular Biology, Vol 503. Humana Press, Totowa, NJ., pp. 239-258 (2009).
          • Reichert, W. M., J. N. Herron, D. A. Christensen, and H.-K. Wang, "Integrated Optic Waveguide Immunosensor". U.S. Patent 7,537,734 (2009).
          • Q. Xu, S.A. Ibrahim, W.I. Higuchi, S.K. Li. "Ion-exchange Membrane Assisted Transdermal Iontophoretic Delivery of Salicylate and Acyclovir", Int. J. Pharm., 369, 105-113 (2009)
          • Q. Xu, R.P. Kochambilli, Y. Song, J. Hao, W.I. Higuchi, S.K. Li. "Effect of Alternating Current Frequency adn Permeation Enhancers Upon Human Epidermal Membrane", Int. J. Pharm., 372, 24-32 (2009)
          • S.A. Molokia, E-K. Jeong, W.I. Higuchi, S.K. Li. "Transscleral Iontophoretic and Intravitreal Delviery of a Macromolecule: Study of Ocular Distribution In Vivo and Postmortem with MRI", Exp. Eye Res., 88, 418-425 (2009)
          • D. Chantasart, Thaned Pongjanyankul, W.I. Higuchi, S.K. Li. "Effects of Oxygen-Containing Terpenes as Skin Permeation Enhancers on the Lipoidal Pathways of Human Epidermal Membrane", J. Pharm. Sci., 98, 10, 3617-3532 (2009)
          • Steimer JL, Dahl S, De Alwis D, Gundert-Remy U, Karlsson M, Martinkova J, Aarons L, Ahr HJ, Clairambault J, Freyer G, Friberg L, Kern S, Ludwig WD, De Nicolao G, Rocchetti M, Troconiz I: "Modelling the genesis and treatment of cancer: the potential role of physiologically-based pharmacodynamics".  Eur J Cancer, 2009 in press.
          • Goteti K, Garner CE, Utley L, Dai J, Ashwell A, Moustakas DT, Gonen M, Schwartz GK, Kern SE, Zabludoff S, Brassil PJ: "Preclinical pharmacokinetic/pharmacodynamics models to predict synergistic effects of co-administered anti-cancer agents".  Cancer Chemother Pharmacol 2009, in press.
          • Kern SE, "Challenges in conducting clinical trials in children: approaches to improving performance". Exp Rev Clin Pharmacol 2009, 2: in press.
          • Ward RM, Kern SE, "Clinical trials in neonates: a therapeutic imperative".  Clin Pharmacol Ther. 2009, in press
          • Kern SE, Jaron D: "Signal from noise? Using science and engineering principles to control the spread of hypercommunicable diseases". IEEE Eng Med Biol Mag 2009, 28:49-55.
          • Zhu W, Masaki T , Cheung AK, Kern SE, "In-vitro Release of Rapamycin from a Thermosensitive Polymer for the Inhibition of Vascular Smooth Muscle Cell Proliferation". J Bioequiv Availab 1: 3-12 (2009).
          • Tricot G, Kern SE, Barlogie B :  "Re: Tandem vs single autologous hematopoietic cell transplantation for th treatment of multiple myeloma : a systematic review and meta-analysis".  J Natl Cancer Insti 2009; 101:964-66.
          • Habtemariam B, Sallas W, Sunkara G, Kern S, Jarugula V, Pillai G : "Population pharmacokinetics of valsartan in pediatrics".  Drug Metab Pharmacokinet 2009; 24:145-52.
          • SW Kim. Arginine-conjugated bioreducible poly(disulfide amine) polymers for gene delivery systems. U.S. Patent Application #: US20090233365, Publication Date: 9/17/2009, Filed: 1/12/2009. University of Utah
          • SW Kim. Cleavable modification to reducible poly(amido ethylenimine)s to enhance nucleotide delivery. US Patent Application #: US20090142842, Publication Date: 6/4/2009, Filed: 11/7/2008. University of Utah
          • SW Kim. Biodegradable poly(disulfide amine)s for gene delivery. U.S. Patent Application #: US20090130752, Publication Date: 5/21/2009, Filed: 11/7/2008. University of Utah
          •  K. Dušek, M. Dušková-Smrčková, J. Yang, J. Kopeček, "Coiled-Coil Hydrogels. Effect of Grafted Copolymer Composition and Cyclization on Gelation", Macromolecules 42, 2265-2274 (2009)
          • L.C. Radu, J. Yang, J. Kopeček, "Self-Assembling Block Copolymers of Poly[N-(2-hydroxypropyl)methacrylamide] and a b-Sheet Peptide", Macromol. Biosci. 9, 36-44 (2009)
          • J. Kopeček, J. Yang, "Peptide-Directed Self-Assembly of Hydrogels", Acta Biomaterialia 5, 805-816 (2009)
          • R.N. Johnson, P. Kopečková, J. Kopeček, "Synthesis and Evaluation of Multivalent Branched HPMA Copolymer-Fab' Conjugates Targeted to the B-Cell Antigen", Bioconjugate Chem. 20, 129-137 (2009)
          • E. Segal, H. Pan, P. Ofek, T. Ugadawa, P. Kopečková, J. Kopeček, R. Satchi-Fainaro, "Targeting-Angiogenesis-Dependent Calcified Neoplasms Using Combined Polymer Therapeutics", PLoS ONE 4(4) e5233 (2009); doi:10.1371/journal.pone.0005233
          • S. Gao, Y. Sun, P. Kopečková, C.M. Peterson, J. Kopeček, "Antitumor Efficacy of Colon-Specific HPMA Copolymer - 9-Aminocamptothecin Conjugate in Mice Bearing Human Colon Carcinoma Xenografts", Macromolecular Biosci. 9, 1135-1142 (2009)
          • J. Callahan, P. Kopečková, J. Kopeček, "The Intracellular Trafficking and Subcellular Distribution of a Large Array of HPMA Copolymers", Biomacromolecules 10, 1704-1714 (2009)
          • J. Liu, P. Kopečková, P. Bühler, P. Wolf, H. Pan, H. Bauer, U. Elsässer-Beile, J. Kopeček, "Biorecognition and Subcellular Trafficking of HPMA Copolymer - Anti-PMSA Antibody Conjugates by Prostate Cancer Cells", Molecular Pharmaceutics 6, 959-970 (2009)
          • R. Sheparovych, Y. Roiter, J. Yang, J. Kopeček, S. Minko, "Stimuli-Responsive Properties of Peptide-Based Copolymers Studied via Directional Growth of Self-Assembled Patterns on Solid Substrate", Biomacromolecules 10, 1955-1961 (2009)
          • L.C. Radu-Wu, J. Yang, K. Wu, J. Kopeček, "Self-Assembled Hydrogels from Poly[N-(2-Hydroxypropyl)methacrylamide] Grafted with b-Sheet Peptides", Biomacromolecules 10, 2319-2327 (2009)
          • J. Kopeček, "Hydrogels. From Soft Contact Lenses and Implants to Self-Assembled Nanomaterials", J. Polym. Sci: Part A: Polym. Chem. 47, 5929-5946 (2009)
          • J. Kopeček, P. Kopečková, "HPMA Copolymers: Origins, Early Developments, Present, and Future", Adv. Drug Delivery Rev. (2009), doi: 10.1016/j.addr.2009.10.004
          • J. Liu, H. Bauer, J. Callahan, P. Kopečková, H. Pan, J. Kopeček, "Endocytic Uptake of a Large Array of HPMA Copolymers: Elucidation into the Dependence on the Physicochemical Characteristics", J. Controlled Release, in press; (2009) COREL5323
          • J. Yang, M.T. Jacobsen, H. Pan, J. Kopeček, "Synthesis and Characterization of Enzymatically Degradable PEG-Based Peptide-Containing Hydrogels", Macromol. Biosci., in press; (2009) 10.1002/mabi.200900295
          • K. Wu, J. Liu, R.N. Johnson, J. Yang, J. Kopeček, "Drug-Free Macromolecular Therapeutics: Induction of Apoptosis by Coiled-Coil Mediated Crosslinking of Antigens on Cell Surface", Angew. Chem. Int. Ed., in press; (2009), 10.1002/anie.200906232
          • Cadwallader, A., Lim, C.S., and Rollins, D.E., "Activity of Abused Steroids in a Cell Based Biological Assay", submitted, Molecular Pharmaceutics
          • Dixon, A.S. and Lim, C.S., "The Nuclear Translocation Assay for Intracellular Protein-Protein Interactions and its Application to the Bcr Coiled-Coil Domain", submitted, Biotechniques
          • Dixon, A.S., Kakar, M, Schneider, K.M.H., Constance, J.E., Paullin, B.C., and Lim, C.S., "Controlling Subcellular Localization to Alter Function: Sending Oncogenic Bcr-Abl to the Nucleus Causes Apoptosis", Journal of Controlled Release, 2009. 140(3): 245-9

2008 Publications

          • H.C. Kang, E.S. Lee, K. Na, Y.H. Bae, "Stimuli-Sensitive Nanosystems: For Drug and Gene Delivery", in Vladimir P. Torchilin (Ed), Series: Fundamental Biomedical Technologies, Vol. 4. Multifunctional Pharmaceutical Nanocarriers, Springer, New York, USA. 2008, pp. 161-199.
          • D. Kim, E.S. Lee, K.T. Oh, Z. Gao, Y.H. Bae*, "Doxorubicin-loaded polymeric micelle overcomes multidrug resistance of cancer by double-targeting folate receptor and early endosomal pH", Small 2008, 4, 2043-2050.
          • Y.H. Bae*, H. Yin, "Stability issues of polymeric micelles (perspective)", J. Control. Rel. 2008, 131, 2-4.
          • E.S. Lee, Y.H. Bae*, "Recent Progress in Tumor pH Targeting", J. Control Rel., 2008, 132, 164-170. (review article).
          • D. Kim, E.S. Lee, K.S. Park, I.C. Kwon, Y.H. Bae*, "Doxorubicin loaded pH-sensitive mixed micelle: antitumoral efficacy against ovarian A2780/DOXR tumor", Pharm. Res., 2008, 5, 2074-2082.
          • B.S. Jin, H.C. Kang, D. Kim, K.H. Lee, Y.H. Bae*, "Synthesis of poly(cystine bisamide)-PEG block copolymers grafted with 1-(3-aminopropyl) imidazole and their phase transition behaviors", Polymer for Advanced Technologies, 2008, 19, 1558-1565.
          • E.S. Lee, Z. Gao, D. Kim, K. Park, I.C. Kwon, Y.H. Bae, "Super pH-sensitive multifunctional polymeric micelle for tumor pHe specific TAT exposure and multidrug resistance", J. Control. Rel. 2008, 129, 228-236.
          • K.T. Oh, E.S. Lee, D.I. Kim, H. Yin, Y.H. Bae, "L-Histidine based pH-sensitive anticancer drug carrier micelle: Reconstitution and brief evaluation of its systemic toxicity", Int. J. Pharm. 2008, 358(1-2), 177-183.
          • A. Taluja, Y.S. Youn, Y.H. Bae, "Role of a novel multifunctional excipient poly(ethylene glycol)-b-oligo (vinyl sulfadimethoxine) in protein delivery from poly(lactide-co-glycolide) microspheres", Int. J. Pharm. 2008, 358(1-2), 50-59.
          • H. Yin, E.S. Lee, K.T. Oh, D.I. Kim, Y.H. Bae, "Physicochemical properties of pH-sensitive poly(L-histidine)-b-poly(ethylene glycol)/ poly(L-lactide)-b-poly(ethylene glycol) mixed micelles", J. Control. Rel., 2008, 126(2), 130-138.
          • V.A. Sethuraman, M.C. Lee, Y.H. Bae*, "A biodegradable pH-sensitive micelle system for targeting acidic solid tumors", Pharm. Res. 2008, 25(3), 657-666. (JIF 3.441 in 2007)
          • E.S. Lee, D. Kim, Y.S. Youn, K.T. Oh, and Y.H Bae, "A novel virus-mimetic nanogel vehicle", Angew. Chem. Int. Ed., 2008, 47(13), 2418-2421.
          • Y.H. Bae, U.S. Patent 7,371,781, "Tumor environment-induced ligand expressing system" (2008) 
          • D. Svozil, J.E. Sponer, I. Marchan, A. Perez, T.E. Cheatham, III, J. Luque, M. Orozco, and J. Sponer.  "Geometrical and electronic structure variability of the sugar-phosphate backbone in nucleic acids."  J. Phys. Chem. B  112, 8188-8197 (2008).
          • In Suk Joung, and T.E. Cheatham, III.  "Determination of alkali and halide monovalent ion parameters for use in explicitly solvated biomolecular simulations"  J. Phys. Chem. B  112, 9020-9041 (2008).
          • TH Chen, Y Bae, and DY Furgeson.  Intelligent biosynthetic nanobiomaterials (IBNs) for hyperthermic gene delivery.  Pharm Res - Theme Issue:  Genetically Engineered Biomaterials (2008) 25(3):683-691. 
          • R. Dandu, J. Cappello, and H. Ghandehari, "Characterization of Structurally Related Adenovirus-Laden Silk-Elastinlike Hydrogels", Journal of Bioactive and Compatible Polymers, 23: 5-19 (2008)
          • K. Kitchens, R. B. Kolhatkar, P. W. Swaan, and H. Ghandehari, "Endocytosis Inhibitors Prevent Poly (Amidoamine) Dendrimer Internalization and Permeability across Caco-2 Cells", Molecular Pharmaceutics, 5: 364-369 (2008)
          • H. Ghandehari, "Recombinant Biomaterials for Pharmaceutical and Biomedical Applications", Pharmaceutical Research, 25: 672-673 (2008)
          • R.B. Kolhatkar, P. Swaan, and H. Ghandehari, "Potential Oral delivery of 7-Ethyl-10-Hydroxy-Camptothecin (SN-38) using Poly(amidoamine) Dendrimers", Pharmaceutical Research, 25: 1723-1729 (2008)
          • R. Kolhatkar, D. Sweet, and H. Ghandehari, "Functionalized Dendrimers as Nanoscale Drug Carriers", In: Multifuctional Pharmaceutical Nanocarriers, V. Torchilin (ed), Springer, pp. 201-232 (2008)
          • B. Zarabi, A. Nan, J. Zhuo, R. Gullapalli, H. Ghandehari, "HPMA Copolymer-Doxorubicin-Gadolinium Conjugates: Synthesis, Characterization, and in vitro Evaluation", Macromolecular Bioscience, 8: 741-748 (2008)
          • A. Nan, X. Bai, S. J. Son, S. B. Lee*, H. Ghandehari*, "Cellular Uptake and Cytotoxicity of Silica Nanotubes", Nano Letters, 8: 2150-2154 (2008)
          • M. P. Borgman, T. Coleman, R. B. Kolhatkar, S. Geyser-Stoops, B. R. Line, H. Ghandehari, "Tumor-Targeted HPMA Copolymer-(RGDfK)-(CHX-A"-DTPA) Conjugates Show Increased Kidney Accumulation", Journal of Controlled Release, 132: 193-199 (2008)
          • H. Ghandehari, "Materials for Advanced Drug Delivery in the 21st Century: a Focus area for Advanced Drug Delivery Reviews", Advanced Drug Delivery Reviews, 60: 956 (2008)
          • A.V. Cresce, R. Dandu, A. Burger, J. Cappello, H. Ghandehari, "Characterization and Real-Time Imaging of Gene Expression of Adenovirus Embedded Silk-Elastinlike Protein Polymer Hydrogels", Molecular Pharmaceutics, 5: 891-897 (2008)
          • D.W. Grainger, D.G. Castner, "Nanobiomaterials and nanoanalysis: how to improve the nanoscience for biotechnology", Adv. Mater. 20, 867 877 (2008).
          • P. Wu, D.G. Castner, D.W. Grainger, "Diagnostic devices as biomaterials: a review of nucleic acid and protein microarray surface performance issues", J. Biomat. Sci. Polym. Ed., 19(6) 725-753, (2008).
          • M.L. Godek, R. Michel, L.M. Chamberlain, D.G. Castner, D.W. Grainger, "Adsorbed serum albumin is permissive to macrophage attachment to polymer surfaces in culture", J. Biomed. Mat. Res., published on line, doi10.1002/jbm.a.31886 (2008); 88A: 503 519, 2009.
          • L.M. Chamberlain, M.L. Godek, M. Gonzalez-Juarrero, D.W. Grainger, "Comparison of murine macrophage cell models for in vitro assessment of the foreign body response", published on line DOI 10.1002/jbm.a.31930 (2008). J. Biomed. Mater. Res., 88A: 858 871, 2009.
          • H. Takahashi, M. Dubey, K. Emoto, D.G. Castner, D.W. Grainger, "Imaging surface immobilization chemistry: correlation with cell patterning on non-adhesive hydrogel thin films", Adv. Funct. Mater., 18 1-10 (2008); doi:10.1002/adfm.200800105.
          • N. Ayres, D. J. Holt, C.F. Jones, L. E. Corum and D.W. Grainger, "Polymer Brushes Containing Sulfonated Sugar Repeat Units: Synthesis, Characterization and In Vitro Testing of Blood Coagulation Activation", doi 10.1002/pola.230752008, J. Polym. Sci, A, Polym Chem 46: 7713-7724, (2008).
          • D.J. Miller, S.K. Li, A.L. Tuitupou, R.P. Kochambilli, K. Papangkorn, D.C. Mix, Jr., W.I. Higuchi, J.W. Higuchi, "Passive and Oxymetazoline-Enhanced Delivery with a Lens Device: Pharmacokinetics and Efficacy Studies with Rabbits", J. Ocul. Pharmacol. Ther., 24, 391-397 (2008)
          • K.S. Warner, D.S. Shaker, S.A. Molokhia, Q. Xu, J. Hao, W.I. Higuchi, S.K. Li. "Silicone Elastomer Uptake Method for Determination of Free 1-Alkyl-2-Pyrrolidone Concentration in Micelle and Hydroxypropyl-B-Cyclodextrin Systems Used in Skin Transport Studies", J. Pharm. Sci., 97, 368-380 (2008)
          • K. Tsutsumi, S.K. Li, R.V. Hymas, C-L Teng, L.G. Tillman, G.E. Hardee, W.I. Higuchi, N.F.H. Ho. "Systematic Studies on the Paracellular Permeation of Model Oligonucleotides in the Rat Small Intestine with Chenodeoxycholate as Enhancer", J. Pharm. Sci., 97, 350-367 (2008)
          • M. Otsuka, A. Oshinbe, R.Z. LeGeros, Y. Tokudome, A. Ito, K. Otsuka and W.I. Higuchi, "Efficacy of the Injectable Calcium Phosphate Ceramics Suspensions Containing Magnesium, Zinc and Fluoride on the Bone Mineral Deficiency in Ovariectomized Rats", J. Pharm. Sci., 97, 421-432 (2008)
          • S.A. Molokhia, Y. Zhang, W.I. Higuchi, S.K. Li. "Iontophoretic Transport Across a Multiple Membrane System", J. Pharm. Sci., 97, 490-505 (2008)
          • W.I. Higuchi, C-S Tzeng, S-J Chang, H-J Chiang, C-L Liu. "Estimation of Cholesterol Solubilization by a Mixed Micelle Binding Model in Aqueous Tauroursodeoxycholate: Lecithin: Cholestrol Solutions", J. Pharm. Sci., 97, 340-349 (2008)
          • S.A. Molokhia, E-K. Jeong, W.I. Higuchi, S.K. Li. "Examination of the Barriers and Barrier Alteration in Transscleral Iontophoresis", J. Pharm.Sci., 97, 831-844 (2008)
          • G. Yan, Q. Xu, Y.G. Anissimov, J. Hao, W.I. Higuchi, S.K. Li. "Alternating Current (AC) Iontophoretic Transport Across Human Epidermal Membrane: Effects of AC Frequency and Amplitude", Pharm. Res., 25, 616-624 (2008)
          • K. Papangkorn, G. Yan, D.D. Heslop, K. Moribe, A.A. Baig, M. Otsuka, W.I. Higuchi. "Influence of Crystallite Microstrain on Surface Complexes Governing the Metastable Equilibrium Solubility Behavior of Carbonated Apatites", J. Colloid and Interface Sci., 320, 96-109 (2008)
          • T.M. Suhonen, S.K. Li. W.I. Higuchi, and J.N. Herron. "A Liposomes Permeability Model for Stratum Corneum Lipid Bilayers Based on Commercial Lipids", J. Pharm. Sci., 97, 4278-4293 (2008)
          • Guo, J., P. Elzinga, M. Hageman, and J. Herron, "Rapid Throughput Screening of Apparent Ksp values for Weakly Basic Drugs Using 96-Well Format". Journal of Pharmaceutical Science 97, 2080-2090 (2008).
          • Herron, J. N., D. A. Christensen, H.-K. Wang, K. D. Caldwell, V. Janatova, and S.-C. Huang. "Apparatus and Methods for MultiAnalyte Homogeneous Fluoroimmunoassays". Canadian Patent 2,162,996 (2008).
          • Guo, J., P. Elzinga, M. Hageman and J. Herron. "Rapid Throughput Solubility Screening Method for BCS Class II Drugs in Animal GI Fluids and Simulated Human GI Fluids Using a 96-well Format". Journal of Pharmaceutical Science 97, 1427-1442 (2008).
          • Kern SE, Stanski DR. "Pharmacokinetics and pharmacodynamics of intravenously administered anesthetic drugs:  Concepts and lessons for drug development".  Clin Pharmacol Ther. 2008, 84:153-57.
          • Kakar M, Davis JR, Kern SE, Lim CS: "Optimizing the protein switch: altering nuclear import and export signals and ligand binding domain".  J Control Release 2007, 120:220-32.
          • Kim KM, Choi BM, Park SW, Lee SH, Christensen LV, Zhou J, Yoo BH, Shin HW, Bae KS, Kern SE, Kang SH, Noh, GJ: "Pharmacokinetics and pharmacodynamics of propofol microemulsion and lipid emulsion after an intravenous bolus and variable rate infusion".  Anesthesiology 2007; 106:924-934.
          • Kern SE, Allen J, Wagstaff J, Shafer SL, Yaksh T: "The pharmacokinetics of the conopeptide Contulakin-G (CGX-1160) after intrathecal administration: an analysis of data from studies in beagles".  Anesth Analg. 2007; 104: 1514-1520.
          • Zhou J, Yockman JW, Kim SW, Kern SE: "Intracellular kinetics of non-viral gene delivery using polyethylenimine carriers". Pharm Res 2007, 24: 1079-87.
          • Kang SH, Poynton MR, Kim KM, Lee H, Kim DH, Lee SH, Bae KS, Linares O, Kern SE, Noh GJ: "Population pharmacokinetic and pharmacodynamics models of remifentanil in healthy volunteers using artificial neural network analysis". Br J Clin Pharmacol 2007; 64:3-13.
          • SW Kim. Soluble steroidal peptides for nucleic acid delivery. (2008) U.S. Patent #: 7,320,890, Issued January 22, 2008, Filed: 4/5/2005. University of Utah
          • C. Xu, J. Kopeček, "Genetically Engineered Block Copolymers: Influence of the Length and Structure of the Coiled-Coil Block on Hydrogel Self-Assembly", Pharmaceutical Res. 25, 674-682 (2008)
          • H. Pan, J. Kopeček, "Multifunctional Water-Soluble Polymers for Drug Delivery, In: Multifunctional Pharmaceutical Nanocarriers (Fundamental Biomedical Technologies, Vol. 4) V.P. Torchilin", Ed., Springer, New York, 2008, pp. 81-142.
          • J. Hongrapipat, P. Kopečková, S. Prakongpan, J. Kopeček, "Enhanced Antitumor Activity of Combinations of Free and HPMA Copolymer-bound Drugs", Int. J. Pharmaceutics 351, 259-270 (2008)
          • S.-Q. Gao, Y. Sun, P. Kopečková, C.M. Peterson, J. Kopeček, "Pharmacokinetic Modeling of Absorption Behavior of 9-Aminocamptothecin (9-AC) Released from Colon-specific HPMA Copolymer - 9-AC Conjugate in Rats", Pharmaceutical Res. 25, 218-226 (2008)
          • J. Yang, K. Wu, Č. Koňák, J. Kopeček, "Dynamic Light Scattering Study of the Self-Assembly of HPMA Hybrid Graft Copolymers", Biomacromolecules 9, 510-517 (2008)
          • K. Wu, J. Yang, Č. Koňák, P. Kopečková, J. Kopeček, "Novel Synthesis of HPMA Copolymers Containing Peptide Grafts and their Self-Assembly into Hybrid Hydrogels", Macromol. Chem. Phys. 209, 467-475 (2008)
          • V. Cuchelkar, P. Kopečková, J. Kopeček, "Synthesis and Biological Evaluation of Disulfide-Linked HPMA Copolymer- Mesochlorin e6 Conjugates", Macromol. Biosci. 8, 375-383 (2008)
          • H. Pan, J. Liu, Y. Dong, M. Sima, P. Kopečková, M.L. Brandi, J. Kopeček, "Release of Prostaglandin E1 from N-(2-Hydroxypropyl)methacrylamide Copolymer Conjugates by Bone Cells", Macromol. Biosci. 8, 599-605 (2008)
          • H. Pan, M. Sima, P. Kopečková, K. Wu, S. Gao, J. Liu, D. Wang, S.C. Miller, J. Kopeček, "Biodistribution and Pharmacokinetic Studies of Bone-Targeting N-(2-Hydroxypropyl)methacrylamide Copolymer - Alendronate Conjugates", Molecular Pharmaceutics 5, 548-558 (2008)
          • V. Cuchelkar, P. Kopečková, J. Kopeček, "Novel HPMA Copolymer-Bound Constructs for Combined Tumor and Mitochondrial Targeting", Molecular Pharmaceutics 5, 776-786 (2008)
          • J. Hongrapipat, P. Kopečková, J. Liu, S. Prakongpan, J. Kopeček, "Combination Chemotherapy and Photodynamic Therapy with Fab' Fragment Targeted HPMA Copolymer Conjugates in Human Ovarian Carcinoma Cells", Molecular Pharmaceutics 5, 696-709 (2008)
          • S.C. Miller, H. Pan, D. Wang, B.M. Bowman, P. Kopečková, J. Kopeček, "Feasibility of Using a Bone-Targeted, Macromolecular Delivery System Coupled with Prostaglandin E1 to Promote Bone Formation in Aged, Estrogen-Deficient Rats", Pharmaceutical Res. 25, 2889-2895 (2008)
          • W. Yuan, J. Yang, P. Kopečková, J. Kopeček, "Smart Hydrogels Containing Adenylate Kinase: Translating Substrate Recognition into Macroscopic Motion", J. Am. Chem. Soc. 130, 15760-15761 (2008)

2007 Publications

      • E.S. Lee, Y.H. Bae, "pH-Sensitive micelles targeting tumor pH", in M. Amiji (Ed.), Nanotechnology for Cancer Therapeutics, CRC Press 2007, pp. 443-464.
      • H.C. Kang, M.H. Lee, Y.H. Bae, "Polymeric gene delivery vectors", in N.A. Peppas, J. Zach Hilt, and J. Brook (Eds), Nanotechnology in Therapeutics: Current Technology and Applications, Horizon Bioscience Press. 2007, pp. 131-161.
      • E.S. Lee, D. Kim, Y.S. Youn, K.T. Oh, and Y.H Bae, "A novel virus-mimetic nanogel vehicle", Angew. Chem. Int. Ed., 2008, 47(13), 2418-2421.
      • E.S. Lee, K.T. Oh, D. Kim, Y.S. Youn, Y.H. Bae*, "Tumor pH-responsive flower-like micelle of poly(L-lactic acid)-b-poly(ethylene glycol)-b-poly(L-histidine)". J. Control. Rel. 2007, 123(1), 19-26.
      • K. Na, E.S. Lee, Y.H. Bae*, "Self-organized nanogels responding to tumor extracellular pH: pH-dependent drug release and in vitro cytotoxicity against MCF-7 wild and resistant cells". Bioconj. Chem. 2007, 18(5), 1568-1574.
      • A. Taluja, Y.S. Youn, Y.H. Bae*, "Novel approaches in microparticulate PLGA delivery systems encapsulating proteins". J. Mater. Chem. 2007, 17, 4002-4014. (review article).
      • K.T. Oh, H. Yin, E.S. Lee, Y.H. Bae*, "Polymeric nanovehicles for anticancer drugs with triggering release mechanisms", J. Mater. Chem. 2007, 17, 3987-4001. (review article).
      • L. Qiu, Y.H. Bae*, "Self-assembled polyethylenimine-graft-poly(e-caprolactone) micelles as dual carrier of genes and anticancer drugs", Biomaterials, 2007, 28(28), 4132-4142.
      • G. Mohazer, E.S. Lee, Y.H. Bae*, "Enhanced Intercellular Retention Activity of a Novel pH-sensitive Polymeric Micelles in Wild and Multidrug Resistant MCF-7 Cells", Pharm. Res. 2007, 24(9), 1618-1627.
      • A. Taluja, Y.H. Bae*, "Role of a novel excipient poly(ethylene glycol)-b-poly(L-histidine) in retention of physical stability of insulin at the aqueous/organic solvent interface", Mol. Pharm. 2007, 4(4), 561-570.
      • A. Taluja, Y.H. Bae*, "Role of a novel excipient poly(ethylene glycol)-b-poly(L-histidine) in retension of physical stability of insulin in aqueous solutions", Pharm. Res. 2007, 24, 1517-26.
      • H.C. Kang, Y.H. Bae*, "pH-Tunable endosomolytic oligomers for enhanced nucleic acid delivery", Advanced Functional Materials, 2007, 17, 1263-1272.
      • V. Sethuraman and Y.H. Bae*, "TAT peptide based micelle system for active targeting of anti cancer agents to acidic solid tumors", J. Control. Rel., 2007, 118, 216-224.
      • Y.H. Bae, U.S. Patent 7,229,973, "pH-sensitive polymeric micelle for drug delivery" (2007)
      • A. Perez, I. Marchan, D. Svozil, J. Sponer, T.E. Cheatham, III, C.A. Laughton, M. Orozco. "Refinement of the AMBER force field for nucleic acids. Improving the description of a/g conformers". Biophys. J. 92, 3817-3829 (2007).
      • A. Wierzbicki, P. Dalal, T.E. Cheatham, III, J.E. Knickelbein, A.D.J. Haymet, and J.D. Madura.  "Antifreeze proteins at the ice/water interface: Three calculated discriminating properties for orientation of type I proteins."  Biophys. J. 93, 1442-1451 (2007).
      • J. Shao, S. W. Tanner, N. Thompson, T.E. Cheatham, III. "Clustering molecular dynamics trajectories: I. Characterizing the performance of different clustering algorithms."  J. Chem. Theory Comp. 3, 2312-2334 (2007).
      • P. Auffinger, T.E. Cheatham, III, and A. C. Vaiana.  "Spontaneous formation of KCl aggregates in biomolecular simulations: a force field issue?"  J. Chem. Theory Comp. 3, 1851-1859 (2007).
      • Y Bae, RA Buresh, TP Williamson, TH Chen, and DY Furgeson.  Intelligent biosynthetic nanobiomaterials for hyperthermic combination chemotherapy and thermal drug targeting of HSP90 inhibitor geldanamycin.  J Control Release (2007) 122(1):16-23.
      • GS Kwon and DY Furgeson.  Biodegradable drug delivery systems: block copolymers and block copolypeptides, in "Biomedical Polymers," M Jenkins (Ed.), pg. 83-110, Woodhead Publishing, Cambridge, UK (2007); ISBN-10 1420044516
      • DY Furgeson and SW Kim.  Linear polyethylenimine-sterol conjugates for gene delivery.  (2007) U.S. Patent #7,183,263; issued 02/27/07; University of Utah.
      •  A. Mitra, A. Nan, B. R. Line, H. Ghandehari, "Polymeric Conjugates for Angiogenesis Targeted Tumor Imaging and Therapy", In Nanotechnology for Cancer Therapeutics, Amiji (Ed), CRC Press, Boca Raton, Florida, pp 159-184 (2007)
      •  A. Hatefi, and H. Ghandehari, "Adenoviral Gene Delivery to Solid Tumors by Recombinant Silk-Elastinlike Polymers", Pharmaceutical Research, 4: 773-779 (2007)
      • M. Haider, J. Cappello, H. Ghandehari* and K.W. Leong*, "In Vitro Chondrogenesis of Mesenchymal Stem Cells in Recombinant Silk-Elastinlike Hydrogels", Pharmaceutical Research, 25: 692-299 (2007)
      • R. Dandu, and H. Ghandehari, "Delivery of Bioactive Agents from Recombinant Polymers", Progress in Polymer Science, 32: 1008-1030 (2007)
      • K. Kitchens, A. Foraker, R. Kolhatkar, P. Swaan and H. Ghandehari, "Endocytosis and Interaction of Poly (Amidoamine) Dendrimers with Caco-2 Cells", Pharmaceutical Research, 24: 2138-2145 (2007)
      • R. Kolhatkar, K. Kitchens, P. Swaan and H. Ghandehari, "Surface Acetylation of Poly(Amidoamine) (PAMAM) Dendrimers Decreases Cytotoxicity while Maintaining Membrane Permeability", Bioconjugate Chemistry, 18: 2054-2060 (2007)
      • S. S. Chandran, A. Nan, D. M. Rosen, H. Ghandehari, S. R. Denmeade, A Prostate-Specific Antigen (PSA)-Activated HPMA Copolymer Prodrug as Dual-Targeted Therapy For Prostate Cancer, Molecular Cancer Therapeutics, 6: 2928-2937 (2007)
      • D. Xue, P. Gong, D.W. Grainger, C.M. Elliott, V. Disette, C.A. Bignozzi, S. Caramori, "Electrochemical detection of DNA hybridization through catalytic oxidation of Co(II) complexes by covalently bound or intercalated Ru(II) complexes", J. Am. Chem. Soc., 129(7):1854-5 (2007).
      • C-Y Lee, P-C.T. Nguyen, D.W. Grainger, L.J. Gamble, D.G. Castner, "Structure and DNA Hybridization Properties of Mixed Nucleic Acid/Maleimide-ethylene glycol monolayers", Analyt. Chem., ACS ASAP DOI: 10.1021/ac0703395, published on line May, 2007: 79: 3390-3400 (2007).
      • I. C. Saldarriaga Fernández, H.C. van der Mei, M.J. Lochhead, D.W. Grainger, H.J. Busscher, "The inhibition of the adhesion of clinically isolated bacterial strains on multi-component cross-linked poly(ethylene glycol)-based polymer coating", Biomaterials, doi:10.1016/j.biomaterials.2007.05.023, 28 4105-4112 (2007).
      • R. Kuijer, E.J.P. Jansen, P.J. Emans, S.K. Bulstra, J. Riesle, J. Pieper, D.W. Grainger, H.J. Busscher, "Assessing infection risk in implanted tissue engineered devices", Biomaterials, doi 10.1016/j.biomaterials.2007.06.003; 28(34):5148-5154 (2007).
      • J.A. Auer, A. Goodship , S. Arnoczky, S. Pearce, J. Price, L. Claes , B. von Rechenberg, M. Hofmann-Amtenbrinck, E. Schneider, R. Muller-Terpitz, F. Thiele, K-P. Rippe, D. W. Grainger, "Refining animal models in fracture research: seeking consensus for optimization of both welfare and scientific validity for appropriate biomedical use", BMC Musculoskel. Disorders 8:72 2007, doi:10.1186/1471-2474-8-72, published on-line August, 2007.
      • C.Y. Lee, G.M. Harbers, D.W. Grainger, L.J. Gamble, D.G. Castner, "Fluorescence, XPS and ToF-SIMS Surface Chemical State Image Analysis of DNA Microarrays", J. Am. Chem. Soc., ACS ASAP 10.1021/ja071879m, 129 9429-9438 (2007).
      • G. Harbers, K. Emoto, C. Greef. S. Metzger, D.W. Grainger, M. Lochhead, "A functionalized poly(ethylene glycol) bioassay surface chemistry facilitates bio-immobilization and inhibits non-specific protein, bacterial, and mammalian cell adhesion", Chem. Mater., ASAP doi 10.1021/cm070509u, 19, 4405-4414 (2007).
      • D.W. Grainger, "Peer review as professional responsibility: a quality control system only as good as the participants", Biomaterials, doi:10.1016/j.biomaterials.2007.07.004 28 5199-5203 (2007).
      • F. Cheng, L.J. Gamble, D.W. Grainger, D.G. Castner, "X-ray Photoelectron Spectroscopy, Time-of-flight Secondary Ion Mass Spectrometry and Principal Component Analysis of the Hydrolysis, Regeneration and Reactivity of NHS-containing Organic Thin Films", Analyt. Chem., 10.1021/ac0715423, 79(22) 8781-8788 (2007). 
      • C. M. Santoro, N.L. Duchsherer, D. W. Grainger, "Minimal antimicrobial efficacy and ocular cell toxicity from silver nanoparticles", Nanobiotechnology, 10.1007/s12030-008-9007-z (published on line, 2007); 3:2, 55-65 (2007).
      • H. Takahashi, D. Letourneur, D.W. Grainger, "Delivery of large biopharmaceuticals from cardiovascular stents: a review" Biomacromolecules, 10.1021/bm700540p, 8(11) 3281-3293 2007.
      • Wei, A.-P and J. N. Herron. "Fluorescence Polarization Immunoassay of High Molecular Weight Antigens". Canadian Patent 2,177,976 (2007).
      • Herron, J. N., D. A. Christensen, V. A. Pollak, R. D. McEachern, and E. M. Simon. "Lens and Associatable Flow Cell".  U.S. Patent RE39,772 (2007).
      • Herron, J. N. and D. A. Christensen. "System for Determining Analyte Concentration". Canadian Patent 2,248,189 (2007).
      • SW Kim. Carrier system for specific artery wall gene delivery. (2007) U.S. Patent #: 7,265,969, Issued September 4, 2007, Filed: 11/9/2001. University of Utah
      • SW Kim. Linear polyethylenimine-sterol conjugates for gene delivery. (2007) U.S. Patent #: 7,183,263, Issued February 27, 2007, Filed: 7/17/2003. University of Utah
      • SW Kim. Polymeric carrier for delivery of small interfering RNA. U.S. Patent Application #: US2007020966, Publication Date: 9/6/2007, Filed: 3/3/2006. University of Utah
      • SW Kim. Linear polyethylenimine-sterol conjugates for gene delivery. U.S. Patent Application #: US20070154447, Publication Date: 7/5/2007, Filed: 1/27/2007. University of Utah
      • SW Kim. Combination gene for use in inhibiting cancerous cell growth. U.S. Patent Application #: US20070111959, Publication Date: 5/17/2007, Filed: 11/17/2005. University of Utah
      • C. Xu, J. Kopeček, "Self-Assembling Hydrogels", Polymer Bulletin 58, 53-63 (2007)
      • S. Gao, Z.-R. Lu, P. Kopečková, J. Kopeček, "Biodistribution and Pharmacokinetics of Colon-Specific HPMA Copolymer - 9-Aminocamptothecin Conjugate in Mice", J. Controlled Release 117, 179-185 (2007)
      • J. Kopeček. J. Yang, "Hydrogels as Smart Biomaterials", Polymer Int. 56, 1078-1098 (2007)
      • J. Kopeček, "Polymeric Biomaterials and Drug Delivery Systems", J. Jpn. Biomat. Soc. 25, 123-135 (2007)
      • H. Ding, P. Kopečková, J. Kopeček, "Self-Association Properties of HPMA Copolymers Containing an Amphipatic Heptapeptide", J. Drug Targeting 15, 465-474 (2007)
      • A. Malugin, P. Kopečková, J. Kopeček, "Liberalization of Doxorubicin from HPMA Copolymer Conjugate is Essential for the Induction of Cell Cycle Arrest and Nuclear Fragmentation in Ovarian Carcinoma Cells", J. Controlled Release 124, 6-10 (2007)
      • D. Wang, S.C. Miller, L.S. Shlyakhtenko, A.M. Portillo, X.-M. Liu, K. Papangkorn, P. Kopečková, Y. Lyubchenko, W.I. Higuchi, J. Kopeček, "Osteotropic Peptide That Differentiates Functional Domains of the Skeleton", Bioconjugate Chem. 18, 1375-1378 (2007)
      • J. Kopeček, "Hydrogel Biomaterials: A Smart Future?" Biomaterials 28, 5185-5192 (2007)
      • H. Pan, P. Kopečková, J. Liu, D. Wang, S.C. Miller, J. Kopeček, "Stability in Plasmas of Various Species of HPMA Copolymer-PGE1 Conjugates", Pharmaceutical Res. 24, 2270-2280 (2007)
      • Lim, C.S., "Organelle-specific targeting in drug delivery and design". Advanced Drug Delivery Reviews, 2007, 59(8):697. Theme editor also of this issue.
      • Kakar, M., Davis, J.R., Kern, S.E., and Lim, C.S., "Optimizing the protein switch: altering nuclear import and export signals, and ligand binding domain", Journal of Controlled Release, 2007 Jul 31;120(3):220-32. Epub 2007 May 3.
      • Kakar, M., Cadwallader, A.B., Davis, J.R., and Lim, C.S., "Signal sequences for targeting of gene therapy products to subcellular compartments:  The role of CRM1 in nucleocytoplasmic shuttling of the protein switch". Pharm Res, 2007 Jun 13; 24(11): 2146-55