Shashank Tandon

ShashankTitle: Research Assistant Professor

Email: Shashank.tandon@utah.edu

 

Education:

PhD (Neuroscience), National Brain Research Centre, India, 2010

M.Sc. (Physiology), All India Institute of Medical Sciences, India, 2003

B.Sc. (Hons.) (Human Biology), All India Institute of Medical Sciences, India, 2001                                                                       

Research Interest:

My research focuses on understanding the neural correlates of reward and aversion and how they play a role in modulating appetitive and consummatory behavior for natural rewards and drugs of abuse. To this end, I am employing electrophysiological and behavioral techniques in rats to determine the brain mechanisms mediating appetitive behavior driving intake of highly palatable high fat/sugar food, as well as ethanol. Specifically, I am interested in determining the role of opioid signaling in the nucleus accumbens (NAcc), an important node in the reward pathway, in normal feeding and binge eating behavior. Another area of focus is the brain circuitry regulating ethanol intake, with a goal of determining the role of the lateral habenula (LHb), a crucial area in which aversive stimuli are encoded, in regulating voluntary ethanol consumption during early and late stage of alcohol abuse.

Selected Publications

Tandon S, Keefe KA, Taha, SA. Mu Opioid Receptor signaling in Nucleus Accumbens Shell Increase Responsiveness of Satiety-Modulated Lateral Hypothalamus Neurons. European Journal of Neuroscience, 2017 Apr 10. DOI: 10.1111/ejn.13579.

Tandon S, Keefe KA, Taha, SA. Excitation of Lateral Habenula Neurons as a Neural Mechanism Underlying Ethanol-Induced Conditioned Taste Aversion Journal of Physiology, 2016 Sep 28. DOI: 10.1113/JP272994.

Haack AK, Sheth C, Schwager AL, Sinclair MS, Tandon S, Taha SA. Lesions of the Lateral Habenula Increase Voluntary Ethanol Consumption and Operant Self-Administration, Block Yohimbine-Induced Reinstatement of Ethanol Seeking, and Attenuate Ethanol-Induced Conditioned Taste Aversion  PloS One,  2014 April 9 (4).

Tandon S, Kambi N, Mohammed H, Jain N. Complete Reorganization of the Motor Cortex of Adult Rats Following Long-Term Spinal Cord Injuries. European Journal of Neuroscience 2013 Jul; 38(2):2271-9.

Tandon S, Simon SA and Nicolelis MAL. Appetitive Changes During Salt Deprivation Are Paralleled by Widespread Neuronal Adaptations in Nucleus Accumbens, Lateral Hypothalamus and Central Amygdala. Journal of Neurophysiology, 2012 108 (4), 1089-1105.

Kambi N, Tandon S, Hisham M, Lazar L & Jain N.   Reorganization of the Primary Motor Cortex of Adult Macaque Monkeys Following Sensory Loss Due to Partial Spinal Cord Injuries. Journal of Neuroscience, 2011 Mar 9; 31(10):3696-707.

Tandon S,   Kambi   N,    lazar    L,    Hisham    M    &    Jain    N.  Plasticity    in Somatosensory Areas S2/PV Following Injuries to the Dorsal Columns of the Spinal Cord in Monkeys. Journal of Neuroscience, 2009 Sep 23; 29(38):12009-19.

Tandon S, Kambi N, Jain N.  Overlapping Representations of the Neck and Whiskers in the Rat Motor Cortex Revealed by Mapping at Different Anesthetic Depths. European Journal of Neuroscience, 2008 Vol. 27, 228–237.

 

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