U of U Research Article 'Subchronic Toxicity of Silica Nanoparticles as a Function of Size and Porosity' Featured as Cover Story in July Issue of Journal of Controlled Release
Jul 25, 2019 9:30 AM
University of Utah researchers Raziye Mohammadpour, Mostafa Yazdimamaghani, Darwin L. Cheney, Jolanta Jedrzkiewicz, and Hamidreza Ghandehari were honored to have their article entitled 'Subchronic Toxicity of Silica Nanoparticles as a Function of Size and Porosity' featured as the cover story in the July issue of the Journal of Controlled Release (Volume 304). Despite the promise of inorganic nanomaterials for use in delivery, diagnosis, and therapy there is a gap in understanding the potential long-term toxicity of these particles. This study explored the acute and subchronic toxicity of silica nanoparticles as a function of size and porosity in male and female mice. Results demonstrate that acute studies, while useful, do not provide a detailed projection of potential long term effects and that the sex of the species can play a role in the biological fate of inorganic nanoparticles.