Al-Hilal Lab Published in Advanced Science
Congratulations to the authors from the Taslim Al-Hilal Lab (Byoungmo Kim, Zulfikar Azam, Riajul Wahab, Farzana Alam, and all co-authors/collaborators) on their recent publication in Advanced Science "Selective Targeting of Tip Endothelial Cells as a Therapeutic Strategy for Tumor Angiogenesis.”
This study addresses a longstanding challenge in cancer research: the selective targeting of tip endothelial cells (TipECs) in solid tumors. The team identified Doppel as a specific marker of TipECs and developed a novel, antibody-based, druggable strategy to target it. Using first-in-class anti-Doppel monoclonal antibodies, the researchers selectively depleted VEGFR2⁺ TipECs without affecting StalkECs. This precise targeting significantly reduced tumor vascularization and growth. These findings position Doppel as a promising therapeutic target and open new avenues for precision anti-angiogenic cancer therapy.
Thank you to the NIH and Department of Defense for supporting this work.
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