Hamid Ghandehari

Hamid Ghandehari

Title: USTAR Professor

Contact Information:

Sorenson Molecular Biotechnology Building
36 S. Wasatch
Salt Lake City, UT 84112
PHONE: 801-587-1566
FAX: 801-585-0575

Email address: hamid.ghandehari@pharm.utah.edu

Go to the Lab Website

Education and Training:

  • Ph.D., Pharmaceutics and Pharmaceutical Chemistry,
    University of Utah
    Salt Lake City, UT
  • Bachelor of Pharmacy,
    University of Utah
    Salt Lake City, UT

Research Interests:

The main focus of research in the Ghandehari laboratory is the development of novel methods for controlled delivery of bioactive agents. Four areas are being explored:

  • Genetically engineered polymers for gene delivery
  • Water-soluble polymers for targeted delivery
  • Poly (amidoamine) dendrimers for oral delivery
  • Inorganic nanoconstructs for controlled chemical delivery

Selected Publications:

  • G. Thiagarajan, A. Ray, A. Malugin, H. Ghandehari. "PAMAM-Camptothecin Conjugate Inhibits Proliferation and Induces Nuclear Fragmentation in Colorectal Carcinoma Cells", Pharm REs. 2010 (in press).
  • J.A. Gustafson, H. Ghandehari. "Silk-elastinlike protein polymers for matrix-mediated cancer gene therapy", Adv Drug Deliv Rev. 2010 (in press).
  • D.S. Goldberg, H. Ghandehari, P.W. Swaan. "Cellular Entry of G3.5 Poly (amino amine) Dendrimers by Clathrin- and Dynamin-Dependent Endocytosis Promotes Tight Junctional Opening in Intestinal Epithelia", Pharm Res. 2010 (in press).
  • D.B. Pike, H. Ghandehari. "HPMA copolymer-cyclic RGD conjugates for tumor targeting", Adv Drug Deliv Rev. 2010 Feb 17;62(2): 167-83.
  • Arnida, A. Malugin, H. Ghandehari. "Cellular uptake and toxicity of gold nanoparticles in prostate cancer cells: a comparative study of rods and spheres", J appl Toxicol. 2010 (3): 212-7.
  • K. Kitchens, and H. Ghandehari, "PAMAM Dendrimers as Nanoscale Oral Drug Delivery Systems", in Nanotechnology in Drug Delivery, M.M. deVilliers, P. Aramwit, and G.S. Kwon (Eds), Springer Science, New York, NY, pp. 423-459 (2009)
  • R. Dandu, A. V. Cresce, R. Briber, P. Dowell, J. Cappello, H. Ghandehari, "Silk-elastinlike Protein Polymer Hydrogels: Influence of Monomer Sequence on Physicochemical Properties", Polymer, 50: 366-374 (2009)
  • D. Hwang, V. Moolchandani, R. Dandu, M. Haider, J. Cappello, and H. Ghandehari, "Influence of Polymer Structure and Biodegradation on DNA Release from Silk-Elastinlike Protein Polymer Hydrogels", International Journal of Pharmaceutics, 368: 215-219 (2009)
  • D.M. Sweet, R.B. Kolhatkar, P. Swaan, and H. Ghandehari, "Transepithelial Transport of PEGylated Anionic Poly (amido amine) Dendrimers: Implications for Oral Drug Delivery", J Controlled Release, 138: 78-85 (2009)
  • B. Zarabi, M.P. Borgman, J. Zhuo, R. Gullapalli, and H. Ghandehari, "Noninvasive Monitoring of HPMA Copolymer-RGDfK Conjugates by Magnetic Resonance Imaging", Pharmaceutical Research, 26: 1121-1129 (2009)
  • M.P. Borgman, A. Ray, R.B. Kolhatkar, E.A. Sausville, A.M. Burger, and H. Ghandehari, "Targetable HPMA Copolymer-Aminohexylgeldanamycin Conjugates for Prostate Cancer Therapy", Pharmaceutical Research, 26: 1407-1418 (2009)
  • A. Hatefi and H. Ghandehari, "Recombinant Polymers: Promise for Gene Therapy", Controlled Release Society Newsletter, 26(2): 16-18(2009)
  • K. Greish, K. Araki, D. Li, B.W. O'Malley Jr., R. Dandu, J. Frandsen, J. Cappello, and H. Ghandehari, "Silk-Elastinlike Protein Polymer Hydrogels for Localized Adenoviral Gene Therapy of Head and Neck Tumors", Biomacromolecules, 10: 2183-2188 (2009)
  • W. Hwang, B-H. Kim, R. Dandu, J. Cappello, H. Ghandehari, and J. Seog, "Surface Induced Nanofiber Growth by Self-Assembly of a Silk-Elastinlike Protein Polymer", Langmuir, 25: 12682-12686 (2009)
  • J. Gustafson, K. Greish, J. Frandsen, J. Cappello, and H. Ghandehari, "Silk-Elastinlike Recombinant Polymers for Gene Therapy of Head and neck Cancer: From Molecular Definition to Controlled Gene Expression", J. Controlled Release,  doi:10.1016/j.jconrel.2009.05.022 [Epub ahead of print]
  • Arnida, A. Malugin, and H. Ghandehari, "Cellular Uptake and Toxicity of Gold Nanoparticles in Prostate Cancer Cells: A Comparative Study of Rods and Spheres", Journal of Applied Toxicology, DOI: 10.1002/jat.1486 [Epub ahead of print]
  • M.P. Borgman, O. Aras, S. Geyser-Stoops, E.A. Sausville, and H. Ghandehari, "Biodistribution of HPMA Copolymer-Aminohexylgeldanamycin-RGDfK Conjugates for Prostate Cancer Drug Delivery", Molecular Pharmaceutics, DOI: 10.1021/mp900134c [Epub ahead of print]
  • R. Dandu, J. Cappello, and H. Ghandehari, "Characterization of Structurally Related Adenovirus-Laden Silk-Elastinlike Hydrogels", Journal of Bioactive and Compatible Polymers, 23: 5-19 (2008)
  • K. Kitchens, R. B. Kolhatkar, P. W. Swaan, and H. Ghandehari, "Endocytosis Inhibitors Prevent Poly (Amidoamine) Dendrimer Internalization and Permeability across Caco-2 Cells", Molecular Pharmaceutics, 5: 364-369 (2008)
  • H. Ghandehari, "Recombinant Biomaterials for Pharmaceutical and Biomedical Applications", Pharmaceutical Research, 25: 672-673 (2008)
  • R.B. Kolhatkar, P. Swaan, and H. Ghandehari, "Potential Oral delivery of 7-Ethyl-10-Hydroxy-Camptothecin (SN-38) using Poly(amidoamine) Dendrimers", Pharmaceutical Research, 25: 1723-1729 (2008)
  • R. Kolhatkar, D. Sweet, and H. Ghandehari, "Functionalized Dendrimers as Nanoscale Drug Carriers", In: Multifuctional Pharmaceutical Nanocarriers, V. Torchilin (ed), Springer, pp. 201-232 (2008)
  • B. Zarabi, A. Nan, J. Zhuo, R. Gullapalli, H. Ghandehari, "HPMA Copolymer-Doxorubicin-Gadolinium Conjugates: Synthesis, Characterization, and in vitro Evaluation", Macromolecular Bioscience, 8: 741-748 (2008)
  • A. Nan, X. Bai, S. J. Son, S. B. Lee*, H. Ghandehari*, "Cellular Uptake and Cytotoxicity of Silica Nanotubes", Nano Letters, 8: 2150-2154 (2008)
  • M. P. Borgman, T. Coleman, R. B. Kolhatkar, S. Geyser-Stoops, B. R. Line, H. Ghandehari, "Tumor-Targeted HPMA Copolymer-(RGDfK)-(CHX-A"-DTPA) Conjugates Show Increased Kidney Accumulation", Journal of Controlled Release, 132: 193-199 (2008)
  • H. Ghandehari, "Materials for Advanced Drug Delivery in the 21st Century: a Focus area for Advanced Drug Delivery Reviews", Advanced Drug Delivery Reviews, 60: 956 (2008)
  • A.V. Cresce, R. Dandu, A. Burger, J. Cappello, H. Ghandehari, "Characterization and Real-Time Imaging of Gene Expression of Adenovirus Embedded Silk-Elastinlike Protein Polymer Hydrogels", Molecular Pharmaceutics, 5: 891-897 (2008)
  •  A. Mitra, A. Nan, B. R. Line, H. Ghandehari, "Polymeric Conjugates for Angiogenesis Targeted Tumor Imaging and Therapy", In Nanotechnology for Cancer Therapeutics, Amiji (Ed), CRC Press, Boca Raton, Florida, pp 159-184 (2007)
  •  A. Hatefi, and H. Ghandehari, "Adenoviral Gene Delivery to Solid Tumors by Recombinant Silk-Elastinlike Polymers", Pharmaceutical Research, 4: 773-779 (2007)
  • M. Haider, J. Cappello, H. Ghandehari* and K.W. Leong*, "In Vitro Chondrogenesis of Mesenchymal Stem Cells in Recombinant Silk-Elastinlike Hydrogels", Pharmaceutical Research, 25: 692-299 (2007)
  • R. Dandu, and H. Ghandehari, "Delivery of Bioactive Agents from Recombinant Polymers", Progress in Polymer Science, 32: 1008-1030 (2007)
  • K. Kitchens, A. Foraker, R. Kolhatkar, P. Swaan and H. Ghandehari, "Endocytosis and Interaction of Poly (Amidoamine) Dendrimers with Caco-2 Cells", Pharmaceutical Research, 24: 2138-2145 (2007)
  • R. Kolhatkar, K. Kitchens, P. Swaan and H. Ghandehari, "Surface Acetylation of Poly(Amidoamine) (PAMAM) Dendrimers Decreases Cytotoxicity while Maintaining Membrane Permeability", Bioconjugate Chemistry, 18: 2054-2060 (2007)
  • S. S. Chandran, A. Nan, D. M. Rosen, H. Ghandehari, S. R. Denmeade, A Prostate-Specific Antigen (PSA)-Activated HPMA Copolymer Prodrug as Dual-Targeted Therapy For Prostate Cancer, Molecular Cancer Therapeutics, 6: 2928-2937 (2007)

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