ADD Program

The project uses animal seizure models and neuroscience techniques to help develop new antiepileptic agents. Some 800-1000 novel compounds per year are evaluated against conventional drugs for anticonvulsant efficacy and potency, neurotoxicity, effect on liver function, and mechanism of action. Promising compounds, which exhibit a high level and/or unusual spectrum of anticonvulsant activity with superior therapeutic potential, are selected for detailed toxicology studies and subsequent clinical trials in epileptic patients. The project has been continually funded since 1975 and every new anticonvulsant introduced to clinical use in the USA during the past 40 years has been evaluated in this research program.

The program is an integral part of the Department of Pharmacology and Toxicology and, as such, provides a site for research training of undergraduate students, departmental graduate students and postdoctoral fellows. Faculty aligned with the program also provide instruction to professional students in the College of Pharmacy and the School of Medicine.

ADD's College of Pharmacy’s Program Awarded $19.5M Contract Renewal To Identify Compounds for Treating Therapy-Resistant Epilepsy

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Latest News

Research, Education
Dec 13, 2016

Voices in Precision Medicine: Speaking on the Law, Ethics, and Science

Huntsman Cancer Institute, Select..., , precision medicine, cancer, ethics

Precision medicine promises health care tailored to every individual, a mission that opens exciting possibilities and poses unique challenges. How do we control cost, equalize access to care, and speed the journey to success? On Dec 1 and 2, 2016, scientists, doctors, lawyers, and ethicists from across the country met to discuss these topics, and more.... Read More

Human Genetics
Jul 11, 2016

New L. S. Skaggs Patient Wellness Center Opens July 11; Takes Interprofessional Approach to Serving Patients With Chronic Disease and Disability

The new L. S. Skaggs Patient Wellness Center, located in the Ray and Tye Noorda Oral Health Sciences Building, will open to the public on July 11. Funded by the Skaggs Foundation for Research and the JAX Foundation, the 4,000-square-foot center will house a large gym, the Jack Lunt Learning Annex, and three private consultation rooms. The new center will take an innovative, interprofessional approach to improving the health of patients with chronic disease or disability.... Read More

Nov 12, 2015

ER visits, hospitalizations decline in elderly patients evaluated by DNA testing and predictive medication analytics system

precision medicine, pharmacogenetics, pharmacy

YouScript predictive medication analytics, a clinical decision support tool used by doctors to guide genetic testing and improve drug treatments, has been shown to cut ER visits by almost three-quarters and reduce hospitalizations by more than one-third in elderly patients taking multiple medications. Researchers from the University of Utah compared those who received YouScript-guided genetic testing and analysis in a prospective group to those who did not in a matched retrospective cohort. YouScript was shown to reduce ER visits by 71 percent and hospitalizations by 39 percent in the tested population compared to the statistically matched group.... Read More

How Low to Go for Blood Pressure? Lower Target Could Affect Millions of Americans
Nov 09, 2015

How Low to Go for Blood Pressure? Lower Target Could Affect Millions of Americans

heart, high blood pressure

A new study finds that at least 16.8 million Americans could potentially benefit from lowering their systolic blood pressure (SBP) to 120 mmHg, much lower than current guidelines of 140 or 150 mmHg. The collaborative investigation between the University of Utah, University of Alabama at Birmingham, and Columbia University, will be published Nov. 9 online in the Journal of the American College of Cardiology (JACC).... Read More

Population Health Sciences
Apr 06, 2015

Severe Malaria Marked by Unique Biochemical Changes: Finding Could Lead to Better Treatments

Previous studies by an international team of malaria researchers had shown that this condition is also marked by lower production of nitric oxide in the cells lining these micro-vessels. Reversing this deficiency could help prevent malaria-infected red cells from sticking to blood vessel walls and avoid this dire condition. A follow-up study by these researchers in Tanzania, Indonesia, Australia and the U.S. has shown one reason for poor nitric oxide production. A critical co-factor for an enzyme that produces nitric oxide must be “charged” with potential energy. ... Read More

Message from the Director

Karen Wilcox, Ph.D.

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