ADD Program

The project uses animal seizure models and neuroscience techniques to help develop new antiepileptic agents. Some 800-1000 novel compounds per year are evaluated against conventional drugs for anticonvulsant efficacy and potency, neurotoxicity, effect on liver function, and mechanism of action. Promising compounds, which exhibit a high level and/or unusual spectrum of anticonvulsant activity with superior therapeutic potential, are selected for detailed toxicology studies and subsequent clinical trials in epileptic patients. The project has been continually funded since 1975 and every new anticonvulsant introduced to clinical use in the USA during the past 40 years has been evaluated in this research program.

The program is an integral part of the Department of Pharmacology and Toxicology and, as such, provides a site for research training of undergraduate students, departmental graduate students and postdoctoral fellows. Faculty aligned with the program also provide instruction to professional students in the College of Pharmacy and the School of Medicine.

ADD's College of Pharmacy’s Program Awarded $19.5M Contract Renewal To Identify Compounds for Treating Therapy-Resistant Epilepsy

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Latest News

Education, Clinical
Nov 08, 2017

Risk for Carbon Monoxide Poisoning Increases in Winter

Each year, carbon monoxide (CO) poisoning is responsible for more than 50,000 emergency department visits, causing more than 400 deaths according to the Centers for Disease Control and Prevention. Americans aged 65 and older are among the highest fatalities.... Read More

Two Studies Support Intensive Blood Pressure Control for Long-term Health, Quality of Life
Research
Aug 23, 2017

Two Studies Support Intensive Blood Pressure Control for Long-term Health, Quality of Life

Internal Medicine, , blood pressure, hypertension, geriatrics

Two studies provide additional support for lowering systolic blood pressure to an intensive goal of 120 mmHg – far below the standard guidelines of 140 mmHg – to reduce the risk of heart disease in high-risk patients with hypertension. The new research shows that intensive blood pressure control is well-tolerated by patients and is cost-effective in terms of health-related quality of life and financial costs to the healthcare system.... Read More

Population Health Sciences

Message from the Director

Karen Wilcox, Ph.D.

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