News & Events
Nguyen TK, Arungundram S, Tran VM, Raman K, Al-Mafraji K, Venot A, Boons GJ, Kuberan B. "A synthetic heparan sulfate oligosaccharide library reveals the novel enzymatic action of D-glucosaminyl 3-O-sulfotransferase-3a"http://pubs.rsc.org/en/
Mol. Biosyst. 8, 609-614 (2012).
Baron R, Vellore NA. "LSD1/CoREST reversible opening/closing dynamics: Discovery of a nanoscale clamp for chromatin and protein binding." http://pubs.acs.org/doi/abs/
10.1021/bi300068r Biochemistry, 51, 3151-3153 (2012).
Debnath A, Parsonage D, Andrade R, He C, Cobo E, Hirata K, Chen S, Garcia-Rivera G, Orozco E, Martinez M, Gunatilleke S, Barrios AM, Arkin M, Poole L, McKerrow J, Reed S. "A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target." http://www.nature.com/nm/
Nature Med. 18, 956-960 (2012).
Robertson CR, Pruess TH, Grussendorf E, White HS, Bulaj G. "Generating Orally Active Galanin Analogues with Analgesic Activities" http://onlinelibrary.wiley.com
ChemMedChem, 7, 903-9 (2012).
Henriksen NM, Davis DR, and Cheatham TE III. "Molecular dynamics re-refinement of two different small RNA loop structures using the original NMR data suggest a common structure." http://www.springerlink.com/
content/t2102l77705t1735/ J. Biomol. NMR (2012) [Online First].
Lu Z, Ding Y, Li X-C, Djigbenou DR, Grimberg BT, Ferreira D, Ireland CM, and Van Wagoner RM. "3-Bromohomofascaplysin A, a fascaplysin analogue from a Fijian Didemnum sp. ascidian."http://www.science
pii/S0968089611003993 Bioorg Med Chem 19, 6604.6607 (2011).
Donia MS, Fricke WF, Partensky F, Cox J, Elshahawi SI, White JR, Phillippy AM, Schatz MC, Piel J, Haygood MG, Ravel J, and Schmidt EW. "Complex microbiome underlying secondary and primary metabolism in the tunicate-Prochloron symbiosis."http://www.pnas.
org/content/108/51/E1423.long Proc. Natl. Acad. Sci. 108, E1423-E1432 (2011).
Department of Medicinal Chemistry
Our mission is to create new knowledge for the discovery and development of new pharmaceutical drugs. Our faculty are nationally and internationally recognized for their innovative scientific contributions in basic and applied research.
Current faculty research areas include:
- Discovery and validation for new anti-cancer drugs targeted at lipid signaling
- Computational modeling and simulation of biomolecular structure, dynamics and interactions
- Synthesis of novel anticancer and anti-HIV drugs
- Chemical biology of cell surface-bound carbohydrates such as heparan, chondroitin, dermatan and keratan sulfates.
- Discovery of marine natural products with anti-cancer activity
- Synthesis and testing of novel anti-infective and anti-parasitic drugs
- Application of mass spectrometry and NMR to the elucidation of protein, nucleic acid, and small molecule structures
- Elucidating bacterial and fungal biosynthetic pathways to harness their medical potential
- Synthesis and evaluation of novel biopolymers for site-targeted drug delivery
- Fabrication of biocompatible materials for tissue engineering and wound repair