RESEARCH INTERESTS
We are developing chemical tools to investigate phosphorylation-mediated cellular signaling with the ultimate goals of elucidating the roles of protein phosphatase in health and disease and developing novel phosphatase-targeted therapeutics. For more information, please visit the Barrios Lab.
OPPORTUNITIES
If you are interested in joining the Barrios lab, please contact Dr. Barrios by email. Potential postdoctoral researchers should have a strong background in synthetic chemistry, chemical biology or enzymology. Potential Ph.D. students are encouraged to apply though the Biological Chemistry Graduate Program. Undergraduates interested in gaining research experience are welcome.
RELATED LINKS
Education History
| Undergraduate |
University of Utah |
BS, Chemistry |
|---|---|---|
| Doctoral Training |
Massachusetts Institute of Technology |
PhD Mentor: Stephen J Lippard |
|
Department of Pharmaceutical Chemistry, University of California |
NIH Postdoctoral Fellow Mentor: Charles S Craik |
Selected Publications
Journal Article
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The mechanism of covalent inhibition of LAR phosphatase by illudalic acid. Hansen DT, Rueb NJ, Levinzon ND, Cheatham TE 3rd, Gaston R Jr, Tanvir Ahmed K, Osburn-Staker S, Cox JE, Dudley GB, Barrios AM. Bioorg Med Chem Lett. 2024 May 15;104:129740.
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Derivatives of the Fungal Natural Product Illudalic Acid Inhibit the Activity of Protein Histidine Phosphatase PHPT1. Wang H, Gaston R Jr, Ahmed KT, Dudley GB, Barrios AM. ChemMedChem. 2023 Aug 1;18(15):e202300187.
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Inhibitor Screen Identifies Covalent Inhibitors of the Protein Histidine Phosphatase PHPT1. McCullough BS, Wang H, Barrios AM. ACS Med Chem Lett. 2022 Jul 5;13(7):1198-1201.