Donald K. Blumenthal

blumenthal-4-small.png

Title:

Office: 102A Skaggs Hall
Email: Don.Blumenthal@pharm.utah.edu
Phone: (801) 585-3094
Fax: (801) 585-5111

Education:

  • B.A., 1975, University of California, San Diego
  • Ph.D., 1980, University of California, San Diego, Physiology and Pharmacology

Research Interests

Much of my laboratory's current basic research efforts are directed towards biophysical studies of protein kinases and other signal transduction molecules using fluorescence, circular dichroism (CD), small-angle x-ray (SAXS) and neutron scattering (SANS), and molecular dynamics (MD). We are using these methods to better understand the large-scale dynamic properties of these important drug targets and their role in normal cell function and disease.

We have also recently begun to study human acetylcholinesterase, the enzyme that hydrolyzes the neurotransmitter acetylcholine. This enzyme is the target of nerve gas agents and several drugs that have therapeutic application in treating glaucoma and Alzheimer's disease. We are interested in developing better antidotes to inhibitors of this enzyme by studying the conformational dynamics of the protein using techniques such as SAXS, MD simulations, and neutron and X-ray diffraction.

BlumenthalFigure.jpg

Figure: SAXS/SANS-based Models of PKA RIIbeta Holoenzyme (Blumenthal et al., J Biol Chem 2014)


List of Selected Publications PubMed 


Web Publications:

  • "Goodman & Gilman Online (GGOL)" L.L. Brunton, D.K. Blumenthal, N. Murri, R. Hilal-Dandan, B.C. Knollmann (eds.) On-line version of the 12th edition of Goodman & Gilman's The Pharmacological Basis of Therapeutics ( www.accessmedicine.com, www.accesspharmacy.com, and others)


Book Chapters:

  • Goodman & Gilman's The Pharmacological Basis of Therapeutics Blumenthal DK. 13th ed. Brunton LL, R. Hilal-Dandan, and Knollmann BC, editors. United States: McGraw-Hill Medical; 2017. Chapter 3, Pharmacodynamics: Molecular Mechanisms of Drug Action (in press)
  • Goodman & Gilman's The Pharmacological Basis of Therapeutics Gurgel, H. and Blumenthal DK. 13th ed. Brunton LL, R. Hilal-Dandan, and Knollmann BC, editors. United States: McGraw-Hill Medical; 2017. Chapter 33, Drug Therapy for Dyslipidemias (in press)
  • Goodman & Gilman's The Pharmacological Basis of Therapeutics Blumenthal DK, Garrison JC. 12th ed. Brunton LL, Chabner BA, Knollmann BC, editors. United States: McGraw-Hill Medical; 2011. Chapter 3, Pharmacodynamics: Molecular Mechanisms of Drug Action; p.41-72.

Books Edited:

  • Workbook and Casebook for Goodman & Gilman's The Pharmacological Basis of Therapeutics (Editors: D.A. Rollins, D.K. Blumenthal; 2016)
  • Goodman & Gilman's Manual of Pharmacology & Therapeutics (Editors: L.L. Brunton, K.L. Parker, D.K. Blumenthal, I.L.O. Buxton; 2008)

Upcoming Events

View Calendar

Graduate Students

IT Services

CPCSS - COMPUTER SUPPORT REQUEST

COMPUTER SUPPORT REQUEST