David Moody

 

David Moody

Title:

Research Professor

Email:

David.Moody@utah.edu

Education: 

  • B.A., 1972, University of Kansas, Chemistry
  • Ph.D., 1977, University of Kansas, Experimental Pathology
  • Postdoctoral Fellow, 1977-1980, University of Californai San Francisco


Research Interests

Our laboratory has used the power of mass spectrometry (MS) coupled to liquid or gas chromatography to measure amounts of drugs, drug metabolites and other xenobiotics in biological samples. We often use this technology to provide analytical services to other investigators, either commercially or collaboratively. When funding for research is obtained, we have used MS techniques to study in vitro drug metabolism. This includes use of animal models, human liver microsomes, cDNA-expressed drug metabolizing enzymes and human clinical studies. We have examined the role of cytochrome P450s (CYP) 2D1 in rat metabolism of amphetamine, the involvement of different in CYPs in the metabolism of l-acetylmethadol (LAAM) and methadone, and the involvement of both CYPs and glucuronosyltransferases (UGT) in the metabolism of buprenorphine. Currently we are studying in vitro inhibition of the metabolism of oxycodone, methadone and buprenorphine.


Selected Publications

  • Christodoulides, N., De La Garza, R. 2nd, Simmons, G.W., McRae, M.P., Wong, J., Newton T.F., Smith, R., Mahoney, III J.J., Hohenstein, J., Gomez, S., Floriano, P.N., Talavera, H., Sloan, D.J., Moody, D.E., Andrenyak, D.M., Kosten, T.R., Haque, A., and McDevitt, J.T.. Application of programmable bio-nano-chip system for the quantitative detection of drugs of abuse in oral fluids.  Drug Alcohol Depend. 153: 306-313, 2015.  PMID: 26048639, PMCID: PMC4509839, DOI: 10.1016/j.drugalcdep.2015.04.026
  • Ng, C.M., Dombrowsky, E., Lin, H.P., Erlich, M.E., Moody, D.E., Barrett, J.S. and Kraft, W.K.  Population pharmacokinetic model of sublingual buprenorphine in neonatal abstinence syndrome.  Pharmacotherapy 35: 670-680, 2015.  PMID: 26172282, PMCID: PMC5119858, DOI: 10.1002/phar.1610
  • Grasing, K., Mathur, D., DeSouza, C., Newton, T.F., Moody, D.E., and Sturgill, M.  Cocaine cardiovascular effects and pharmacokinetics after treatment with the acetylcholinesterase inhibitor donezil.  Am. J. Addict. 25: 392-399, 2016.  PMID: 27392137, PMCID: PMC4967259, DOI: 10.1111/ajad.12402
  • DeYoung, D.Z.  Heinzerling, K.G., Swanson, A.N., Tsuang, J., Burst, B.A., Yi, Y, Wu, Y.N., Moody, D.E., Andrenyak, D.M., and Shoptaw, S.J.  Safety of intravenous methamphetamine administration during ibudilast treatment.  J. Clin. Psychopharmacol.  36: 347-354, 2016.  PMID: 27269956, PMCID: PMC4927401, DOI:10.1097/JCP.0000000000000511
  • Andrenyak, D.M., Moody, D.E., Slawson, M.H., and Haney, M.  Determination of ∆-9-tetrahydrocannabinol (THC), 11-hydroxy-THC, 11-nor-9-carboxy-THC and cannabiol in huan plasma using gas chromatography-tandem mass spectrometry.  J. Anal. Toxicol. 41: 277-288, 2017.  PMID: 28069869 PMCID: PMC5412026, DOI: 10.1093/jat/bkw136
  • Moody, D.E.  The inhibition of first-pass metabolism of ethanol by H2-receptor antagonists: a tabulated review.  Expert Opin. Drug Saf. 17: 917-934, 2018.  PMID: 30117350, DOI: 10.1080/14740338.2018.1512969
  • Briones, M., Shoptaw, S., Cook, R., Worley, M, Swanson, A.N., Moody, D.E., Fang, W.B., Tsuang, J., Furst, B., Heinzerling, K.  Varenicline treatment for methamphetamine dependence: A randomized double-blind phase II clinical trial.  Drug Alcohol Depend. 189: 30-36, 2018.  PMID: 29860057, PMCID: PMC6391991, DOI:10.1016/j.drugalcdep.2018.04.023
  • Moore, J.N., Gastonguay, M.R., Adeniyi-Jones, S.C., Moody, D.E., Fang, W.B., Ehrlich, M.E., and Kraft, W.K.  The pharmacokinetics and pharmacodynamics of buprenorphine in neonatal abstinence syndrome.  Clin. Pharmacpol. Ther. 103: 1029-1037, 2018.  PMID: 29516490, PMCID: PMC5992055, DOI: 10.1002/cpt.1064
  • Moody, D.E., Fu, Y., and Fang, W.B.  Inhibition of in vitro metabolism of opioids by skeletal muscle relaxants.  Basic Clin. Pharmacol. Toxicol. 123: 327-334, 2018.  PMID: 29504673, DOI: 10.1111/bcpt.12999
  • Liu, T., Lewis, T.R., Moore, J.N., Kraft, W.K., Gauba, E.B., Sartori, D., Moody, D.E., Gobburu, J.V.S., and Ivaturi, V.  Could postnatal age-related uridine diphosphate glucuronic acid be a rate-limiting factor in metabolism of morphine during the first week of life?  CPT Pharmacometrics Syst. Pharmacol. 8: 469-477, 2019.  PMID: 31044547

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