Dr. Amy Barrios Medicinal Chemistry Department

Amy Barrios

Academic Information

Departments Professor - Biochemistry , School of Medicine , Professor - Medicinal Chemistry , College of Pharmacy

Academic Office Information

Amy.Barrios@utah.edu

801-581-3198

Lab

Research Interests

  • Research in the Barrios lab lies at the interface between chemistry and biology with an emphasis on developing chemical tools for understanding protein phosphorylation mediated cellular signaling
  • The tools developed in our lab provide the foundation for elucidating roles of protein phosphatases in health and disease

RESEARCH INTERESTS

We are developing chemical tools to investigate phosphorylation-mediated cellular signaling with the ultimate goals of elucidating the roles of protein phosphatase in health and disease and developing novel phosphatase-targeted therapeutics. For more information, please visit the Barrios Lab.

OPPORTUNITIES

If you are interested in joining the Barrios lab, please contact Dr. Barrios by email. Potential postdoctoral researchers should have a strong background in synthetic chemistry, chemical biology or enzymology. Potential Ph.D. students are encouraged to apply though the Biological Chemistry Graduate Program. Undergraduates interested in gaining research experience are welcome.

RELATED LINKS

FAR Page

Research Lab

Biological Chemistry Graduate Program

Education History

Undergraduate University of Utah
 BS, Chemistry
Doctoral Training Massachusetts Institute of Technology
 PhD Mentor: Stephen J Lippard
Fellowship Department of Pharmaceutical Chemistry, University of California
 NIH Postdoctoral Fellow Mentor: Charles S Craik

Selected Publications

Journal Article

  1. The mechanism of covalent inhibition of LAR phosphatase by illudalic acid. Hansen DT, Rueb NJ, Levinzon ND, Cheatham TE 3rd, Gaston R Jr, Tanvir Ahmed K, Osburn-Staker S, Cox JE, Dudley GB, Barrios AM. Bioorg Med Chem Lett. 2024 May 15;104:129740.

  2. Derivatives of the Fungal Natural Product Illudalic Acid Inhibit the Activity of Protein Histidine Phosphatase PHPT1. Wang H, Gaston R Jr, Ahmed KT, Dudley GB, Barrios AM. ChemMedChem. 2023 Aug 1;18(15):e202300187.

  3. Inhibitor Screen Identifies Covalent Inhibitors of the Protein Histidine Phosphatase PHPT1. McCullough BS, Wang H, Barrios AM. ACS Med Chem Lett. 2022 Jul 5;13(7):1198-1201.

    More Selected Publications