RESEARCH INTERESTS
Research in our laboratory is directed toward optimizing the activity and selectivity of a lead therapeutic with activity against diverse viruses.
Targeting the translation of viral mRNAs that are obligated to use human cellular processes can provide therapeutics against coronavirus variants and future pandemic viruses. We are elucidating the activity of a class of antivirals having a novel mechanism of action with the expectation this research could provide new therapies.
Reduction of COVID-19 viral infection in Vero cells by compounds DD011-E2, and DD011-E1. The lead compounds are an enantiomeric pair where the E1 isomer is almost inactive against SARS-CoV-2, the EC50 for E2 = 140 nM . Similar differential activity is seen against other coronaviruses (hCoV-OC43), as well as phylogenetically distant viruses such as HCV and Zika. A common pattern of activity supports a conserved, host-targeted mechanism of antiviral activity.
RELATED LINKS
Education History
| Undergraduate |
University of Puget Sound |
BS |
|---|---|---|
| Doctoral Training |
University of Utah |
PhD |
Selected Publications
Journal Article
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Galindo-Murillo, R., Davis, D.R., Cheatham, T.E. (2016) Probing the influence of hypermodified residues within the tRNALys,3 anticodon stem loop interacting with the A-loop primer sequence from HIV-1. Biochem. Biophys. Acta. 1860, 607-617.
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Henriksen, N.M., Hayatshahi, H.S., Davis, D.R., Cheatham, T.E. (2014) Structural and energetic analysis of 2-aminobenzimidazole inhibitors in complex with the hepatitis C virus IRES RNA using molecular dynamics simulations. J. Chem. Inf. Model. 54, 1758-1772.
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Henriksen, N.M., Davis, D.R., and Cheatham, T.E (2012) Molecular dynamics re-refinement of two different small RNA loop structures using the original NMR data suggest a common structure. J. Biomol. NMR, 53, 321-339.