Dissertation Project: A pharmacokinetic and efficacy study of a relevant combination therapy in a mouse model of Dravet SyndromeDissertation Project: A pharmacokinetic and efficacy study of a relevant combination therapy in a mouse model of Dravet Syndrome.
Dravet Syndrome (DS) is a rare but catastrophic infantile-onset genetic epilepsy characterized by febrile and spontaneous seizures with significant comorbidities. The use of monotherapies do fail to provide adequate seizure control in patients; thus, combination therapies have become important. However, there is a limited understanding of drug-drug interactions of antiseizure polytherapy, impeding therapy decision-making. This study utilizes a DS mouse model and a standard-of-care therapeutic approach as a proof-of-principle study to provide an essential drug discovery platform to inform future preclinical studies for new investigational compounds.
Undergraduate School: University of Ghana (MPhil; BSc Biochemistry)
Faculty Mentor: Karen Wilcox, PhD