Education History
Postdoctoral Training |
Oregon State University |
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Graduate Training |
Rhodes University Chemistry |
PhD |
Undergraduate |
Rhodes University Chemistry and Marine Biology |
BS Hons |
Selected Publications
Journal Article
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Avalon, N.E.,* Reis, M.A.,* Thornburg, C.C.,* Williamson, R.T., Petras, D, Aron, A.T…McPhail, K.L., Gerwick, W.H. et al. Leptochelins A-C, Cytotoxic Metallophores Produced by Geographically Dispersed Leptothoe Strains of Marine Cyanobacteria. J. Am. Chem. Soc. 2024, 146, 27: 18626–18638.
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Neuhaus, G.F., Aron, A.T., Isemonger, E.W., Petras, D., Waterworth, S.C., Madonsela, L.S., Gentry, E.C., Siwe Noundou, X., Kalinski, J-C.J., Polyzois, A., Habiyaremye, J.C., Redick, M.A., Kwan, J.C., Dorrington, R.A., Dorrestein, P.C., McPhail, K.L. Environmental metabolomics characterization of modern stromatolites and annotation of ibhayipeptolides. PLoS ONE 2024, 19(5): e0303273. https://doi.org/10.1371/journal.pone.0303273.
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Mattos, D.R., das Neves, W., Kitamura, T., Pradhan, R., Wan, X., da Hora, C.C., Tranter, D., Kazemi, S., Yu, X., Tripathy, N., Paavilainen, V.O., McPhail, K.L., Oishi, S., Badr, C.E., Ishmael, J.E. Diastereomers of Coibamide A show altered Sec61 Client Selectivity and Ligand-Dependent Activity against Patient-derived Glioma Stem-Like Cells. ACS. Pharmacol. Translation. Sci. 2024, 7(6): 1823–1838.
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Vargas-Gastélum, L., Romer, A.S., Alexander, N.R., Ghotbi, M., Dallas, J.W., Alexander, N.R., Moe, K.C., McPhail, K.L., Neuhaus, G.F., Shadmani, L., Spatafora, J.W., Stajich, J.E., Tabima, J.F., Walker, D.M. Herptile gut microbiomes: a natural system to study multi-kingdom interactions between filamentous fungi and bacteria. mSphere, 2024. 9:e00475-23. Doi: 10.1128/msphere.00475-23.
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Redick, M.A., Cummings, M.E., Neuhaus, G.F., Ardor Belluci, L.M., Thurber, A.R., McPhail, K.L. Integration of Untargeted Metabolomics and Microbial Community Analyses to Characterize Distinct Deep-Sea Methane Seeps. Frontiers in Marine Science, 2023, 10: 1197338. Doi: 10.3389/fmars.2023.1197338.
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Suzuki, R., Mattos, D.R., Kitamura, T., Tsujioka, R., Kobayashi, K., Inuki, S., Ohno, H., Ishmael, J.E., McPhail, K.L., Oishi, S. Design of Synthetic Surrogates for the Macrolactone Linker Motif in Coibamide A. ACS Med. Chem. Lett. 2023, 14:1344–1350.
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Tehan, R.M., Dooley, C.B., Barge, E.G., McPhail, K.L., Spatafora, J.W. New species and new combinations in the genus Paraisaria (Hypocreales, Ophiocordycipitaceae) from the U.S.A., supported by polyphasic analysis. Mycokeys 2023, 100: 69-94.
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Tehan, R.M.; Blount, R.R.; Goold, R.L.; Mattos, D.R.; Spatafora, N.R.; Tabima, J.F.; Gazis, R.; Wang, C.; Ishmael, J.E.; Spatafora, J.W.; McPhail, K.L. Tolypocladamide H and the Proposed Tolypocladamide NRPS in Tolypocladium Species. Journal of Natural Products. 2022, 85: 1363-1373.
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Kitamura, T.; Suzuki, R.; Inuki, S.; Ohno, H.; McPhail, K.L.; Oishi, S. Design of coibamide A mimetics with improved cellular bioactivity. ACS Med. Chem. Lett. 2022, 13: 105-110.
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Kazemi, S.; Kawaguchi, S.; Badr, C.E.; Mattos, D.R.; Ruiz-Saenz, A.; Serrill, J.D.; Moasser, M.M.; Dolan, B.P.; Paavilainen, V.O.; Oishi, S.; McPhail, K.L.; Ishmael, Jane E. Targeting of HER/ErbB family proteins using broad spectrum Sec61 inhibitors coibamide A and apratoxin A. Biochemical Pharmacology 2021, 183, 114317.
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Tranter, D., Paatero, A.O., Kawaguchi, S., Kazemi, S., Serrill, J.D.; Kellosalo, J., Vogel, W.K., Richter, U., Mattos, D.R., Wan, X., Thornburg, C.C.; Oishi, S., McPhail, K.L.; Ishmael, J.E., Paavilainen, V.O. Coibamide A targets Sec61 to prevent biogenesis of secretory and membrane proteins. ACS Chemical Biology, 2020, 15, 8, 2125–2136.
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Aron A.T.,* Gentry E.C.,* McPhail, K.L*…Dorrestein, P.D. et al. Reproducible molecular networking of untargeted mass spectrometry data using GNPS. Nat Protoc. 2020, 15(6):1954-1991. PubMed ID: 32405051.