Shuanghu Liu

Shuanghu Liu, PhD

Academic Office Information

shuanghu.liu@hsc.utah.edu

801-585-3409

Research Interests

  • Anti-SARS-Cov2(Covid-19) virus research
  • Screening of anticancer compounds

RESEARCH INTERESTS

My research interests focus on drug screening. Two ongoing projects are as follows:

1. Anti-SARS-Cov2(Covid-19) virus research. We found some compounds that can inhibit the replication of Sars-Cov2 virus. One of them targets on the Sars-Cov2 virus translation process. Its specific mechanism is being studied using the Sars-Cov2 replicon and the Sars-Cov2-5UTR-NSP1-Rluc translation system.

2. Screening of anticancer compounds. We identified two small molecule compounds that can inhibit the growth of cancer cells. One is a c-MYC inhibitor, and another is a Hedgehog pathway inhibitor. The detailed mechanisms of anticancer action are being studied.

Education History

Doctoral Training Hunan Medical University (Current name: Xiangya School of Medicine, Central South University)
 PhD
Graduate Training Hunan Medical University (Current name: Xiangya School of Medicine, Central South University)
 MS
Zhongshan Medical University (Current name: Zhongshan School of Medicine, Sun Yat-sen University)
 MD

Selected Publications

Journal Article

  1. Liu S, Zhang Z, Hu G. Expression of E1, E2/N1 and NS5 genes of hepatitis C virus in E.coli and preliminary use of the expressed proteins. Chinese Journal of Infectious Diseases (Zhonghua Chuan Ran Bing Za Zhi). 1998; (16):5-8.

  2. Liu S, Tan D, Li C. Specific cellular and humoral immune responses in BALB/C mice induced by DNA immunization of HBV HBsAg gene. Zhongnan Daxue Xuebao (Yixue Ban) /Hunan Medical University Bulletin. 1999; 24(4):313-315.

  3. Tan D, Liu S, Li C. Specific cellular and humoral immune responses in BALB/C mice induced by DNA immunization of HCV Core gene. Ji chu yi xue yu lin chuang. 2000; 10(1):78-79.

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