RESEARCH INTERESTS
Dr. Joseph Rower is a Research Assistant Professor in the Department of Pharmacology and Toxicology. Dr. Rower completed his graduate work at the University of Colorado, Anschutz Medical Campus where his research focused on the unique pharmacology of nucleoside reverse transcriptase inhibitors used to treat and prevent HIV infection.
Dr. Rower’s current research focuses on improving the clinical care of children. Specifically, his research focuses on validating bioanalytical methods for determining drug concentrations from small blood volumes. This research has the potential to revolutionize pediatric clinical pharmacology studies, especially in neonates and other populations where blood volume is limited. These advances will enable future studies which can better define the impact of age on the pharmacokinetic-pharmacodynamic relationships. Dr. Rower is especially interested in defining these relationships for drugs used to treat infectious diseases and in transplantation.
Joseph Rower's LAB
The focus of the Rower lab is to understand and implement personalized medicine dosing strategies, particularly in pediatric populations. We utilize a combination of bioanalysis and pharmacometrics to identify patient-specific factors that alter the pharmacokinetics of a drug of interest. Current projects of interest in the lab include personalized dose predictions for pediatric heart transplant recipients receiving tacrolimus-based immunosuppression and the use of (val)ganciclovir to treat congenital cytomegalovirus. Through our integration into the Center for Human Toxicology, the Rower lab is also interested in defining cannabis pharmacokinetics, and investigating the effects of cannabis use in adolescence.
RELATED LINKS
Education History
| Undergraduate |
California Lutheran University |
BS Chemistry, Mathematics |
|---|---|---|
| Doctoral Training |
University of Colorado Anschutz Medical Campus |
PhD Pharmaceutical Sciences |
|
University of Colorado Anschutz Medical Campus |
Postdoctoral Fellow, Systems Biology | |
| Postdoctoral Fellowship |
University of Colorado Anschutz |
Postdoctoral Fellow, Antiviral Pharmacology |
|
University of Utah |
Postdoctoral Fellow, Pediatric Clinical Pharmacology |
Selected Publications
Journal Article
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The Cytochrome P450 2C8*3 Variant (rs11572080) Is Associated with Improved Asthma Symptom Control in Children and Altered Lipid Mediator Production and Inflammatory Response in Human Bronchial Epithelial Cells. Almestica-Roberts M, Nguyen ND, Sun L, Serna SN, Rapp E, Burrell-Gerbers KL, Memon TA, Stone BL, Nkoy FL, Lamb JG, Deering-Rice CE, Rower JE, Reilly CA. Drug Metab Dispos. 2024 Jul 16;52(8):836-846. doi: 10.1124/dmd.124.001684. PMID: 38772712
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A ropivacaine-eluting poly(lactide-co-caprolactone) wound dressing provided enhanced analgesia in partial-thickness porcine injuries. Niederauer S, Beeman M, Cleveland A, Wojtalewicz S, Erickson S, Reilly CA, Rower JE, Garrett C, Floyd C, Shea J, Agarwal J, Lade C, Davis B. Plast Reconstr Surg. 2024 Apr 23. doi: 10.1097/PRS.0000000000011485. Online ahead of print. PMID: 38652817
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Evaluation and comparison of pharmacokinetic profiles and safety of two extended-release buprenorphine formulations in common marmosets (Callithrix jacchus). Fabian NJ, Mannion AJ, Jamiel M, Anderson DJ, Rower JE, Reilly CA, Menegas W, Muthupalani S, Ta C, Fox JG, Kramer R, Haupt JL. Sci Rep. 2023 Jul 22;13(1):11864. doi: 10.1038/s41598-023-38973-2.
PMID: 37481609 Free PMC article.