Karen Wilcox

 

Karen Wilcox

Title:

Professor and Chair


Email:

kwilcox@deans.pharm.utah.edu



Education:

 

B.A. 1981, Allegheny College

Ph.D. 1993, University of Pennsylvania




 

Research Interests

 

The Wilcox laboratory is interested in understanding basic mechanisms underlying epileptogenesis, seizure generation, and therapy-resistance to anticonvulsant drugs. To achieve these goals, we use electrophysiological, calcium imaging, pharmacological, behavioral, genetic, immunoblot, and immunohistochemical techniques in a variety of in vitro preparations and animal models of epilepsy. Our working hypothesis is that insight into disease-induced changes in neuronal and glial function will provide new avenues for therapeutic interventions in patients at risk for developing epilepsy or those patients who are refractory to current treatment options. To that end, I am also a Co-Investigator in the Anticonvulsant Drug Development (ADD) Program (Principal Investigator, H. Steve White, Ph.D) and direct studies determining the neuroprotection potential of proprietary investigational compounds through a contract with NINDS at the National Institutes of Health. Finally I am actively seeking rotation students as well as dissertation student.

Wilcox laboratory




 

Selected Publications

 

Could Astrocytes Be Used to Beat Epilepsy? Experiments in dnSNARE Mice Drum Up New Hope.
Gibbons MB, Wilcox KS.
Epilepsy Curr. 2014 Sep;14(5):277-8. doi: 10.5698/1535-7597-14.5.277. No abstract available.
PMID:  25346638  [PubMed]
Related citations

Imaging activity in neurons and glia with a Polr2a-based and cre-dependent GCaMP5G-IRES-tdTomato reporter mouse.
Gee JM, Smith NA, Fernandez FR, Economo MN, Brunert D, Rothermel M, Morris SC, Talbot A, Palumbos S, Ichida JM, Shepherd JD, West PJ, Wachowiak M, Capecchi MR, Wilcox KS, White JA, Tvrdik P.
Neuron. 2014 Sep 3;83(5):1058-72. doi: 10.1016/j.neuron.2014.07.024. Epub 2014 Aug 21.
PMID:  25155958  [PubMed - indexed for MEDLINE]
Related citations

The challenge and promise of anti-epileptic therapy development in animal models.
Simonato M, Brooks-Kayal AR, Engel J Jr, Galanopoulou AS, Jensen FE, Moshé SL, O'Brien TJ, Pitkanen A, Wilcox KS, French JA.
Lancet Neurol. 2014 Sep;13(9):949-60. doi: 10.1016/S1474-4422(14)70076-6. Epub 2014 Aug 10. Review.
PMID:  25127174  [PubMed - indexed for MEDLINE]
Related citations

Does brain inflammation mediate pathological outcomes in epilepsy?
Wilcox KS, Vezzani A.
Adv Exp Med Biol. 2014;813:169-83. doi: 10.1007/978-94-017-8914-1_14. Review.
PMID:  25012376  [PubMed - indexed for MEDLINE]
Related citations

Antiseizure drugs differentially modulate θ-burst induced long-term potentiation in C57BL/6 mice.
West PJ, Saunders GW, Remigio GJ, Wilcox KS, White HS.
Epilepsia. 2014 Feb;55(2):214-23. doi: 10.1111/epi.12524. Epub 2014 Jan 21.
PMID:  24447124  [PubMed - indexed for MEDLINE]
Related citations

Impaired cognitive ability and anxiety-like behavior following acute seizures in the Theiler's virus model of temporal lobe epilepsy.
Umpierre AD, Remigio GJ, Dahle EJ, Bradford K, Alex AB, Smith MD, West PJ, White HS, Wilcox KS.
Neurobiol Dis. 2014 Apr;64:98-106. doi: 10.1016/j.nbd.2013.12.015. Epub 2014 Jan 9.
PMID:  24412221  [PubMed - indexed for MEDLINE]
Related citations

Vargas, J.R., Takahashi, D.K., Thomson, K.E., and Wilcox, K.S (In press) The expression of kainate receptor subunits in hippocampal astrocytes following experimentally induced status epilepticus. J Neuropathol Exp Neurol

Wilcox, K.S., Dixon-Salazar, T., Ben-Menachem, E., Porter, R.J., Dichter, M.A.,White, H.S., Noebels, J.L., Privitera, M., and Rogawski, M.A. (2013) Development of New Anti-Seizure Treatments. Epilepsia, 54(Suppl. 4):24–34.

Srivastava, A.K., Alex, A.B., Wilcox, K.S., and White H.S. (In press) Rapid loss of efficacy to the antiseizure drugs lamotrigine and carbamazepine: A novel experimental model of pharmacoresistant epilepsy. Epilepsia

Gibbons, M.B., Smeal, R.M., Takahashi, D.K., Vargas, J.R., and Wilcox, K.S. (2013) Contributions of Astrocytes to Epileptogenesis Following Status Epilepticus: Opportunities for Preventive Therapy? Neurochem International.

Smeal, R.M., Economo, M.N., Lillis, K.P., Wilcox, K.S., White, J.A. (2012) Targeted path scanning: an emerging method for recording fast changing network dynamics across large distances. J Bioeng & Biom Sci. S5:002. doi:10.4172/2155-9538.S5-002

Smeal, R. M., Stewart, K. A., Iacob, E., Fujinami, R. S., White, H. S., Wilcox, K. S. (2012) The activity within the CA3 excitatory network during Theiler's virus encephalitis is distinct from that observed during chronic epilepsy. J Neurovir, 18(1): 30-44. PMID: 22328242

Stewart, K.A., Wilcox, K.S., Fujinami, R.S., White, H.S. (2010) Development of postinfection epilepsy after Theiler's virus infection of C57BL/6 mice. J Neuropathol Exp Neurol. 69(12):1210-9. PMID: 21107134.

Takahashi, D.K., Vargas, J.R., Wilcox, K.S. (2010) Increased coupling and altered glutamate transport currents in astrocytes following kainic-acid-induced status epilepticus. Neurobiol of Dis. 40(3):573-85. PMID: 20691786.

Alex, A.B., Saunders, G.W., Dalpe-Charron, A., Reilly, C.A. and Wilcox, K.S. (2011) Conantokin G protects neurons from excitotoxicity through actions at multiple types of NMDA receptors. Neurotoxicol 32(4):392-9 PMID: 21396956.

Smeal, R. M., Stewart, K. A., Iacob, E., Fujinami, R. S., White, H. S., Wilcox, K. S. (2012) The activity within the CA3 excitatory network during Theiler's virus encephalitis is distinct from that observed during chronic epilepsy. J Neurovir, 18(1): 30-44. PMID: 22328242.

Smeal, R.M., Economo, M.N., Lillis, K.P., Wilcox, K.S., White, J.A. (2012) Targeted path scanning: an emerging method for recording fast changing network dynamics across large distances. J Bioeng & Biom Sci., S5.

Stewart, K.A., Wilcox, K.S., Fujinami, R.S., and White, H.S. (In press) Theiler’s virus infection chronically alters seizure susceptibility. Epilepsia

Otto, J.F, Singh, N.A., Leppert, M.F., Dahle, E.J., Pappas, C., Pruess, T., Wilcox, K.S., and White, H.S. (2009) Electroconvulsive Seizure Thresholds and Kindling Acquisition Rates Are Altered in Mouse Models of Human KCNQ2 and KCNQ3 Mutations for Benign Familial Neonatal Convulsions. Epilepsia 50(7): 1752-1759.

Smeal, R. M., Keefe, K.A., and Wilcox, K.S. (2008) Differences in excitatory transmission between thalamic and cortical afferents to single spiny efferent neurons of dorsal striatum. Eur. J. Neurosci. 28(10):2041-52.

Singh, N. A., Otto, J.F, Dahle, E.J., Pappas, C., Leslie, J.D., Vilaythong, A., Noebels, J.L., White, H.S., Wilcox, K. S. , and Leppert, M. F. (2008) Neuronal Plasticity Without Synaptic Reorganization in Kcnq2 and Kcnq3 Mouse Models of Benign Familial Neonatal Convulsions. J Physiol 586(14):3405-23.

White, H.S., Smith, M.D., and Wilcox, K.S. (2007) Mechanisms of action of antiepileptic drugs. Int Rev Neurobiol. 81:85-110.

White, H.S., Smith, M.D., and Wilcox, K.S Mechanisms of action of antiepileptic drugs. Int Rev Neurobiol. 2007;81:85-110. West, P.J., Dalpe-Charron, A., and Wilcox, K.S. (2007) Differential Contribution of Kainate Receptors to Excitatory Postsynaptic Currents in Superficial Layer Neurons of the Rat Medial Entorhinal Cortex. Neuroscience 146(3):1000-12.

West, P.J., Dalpe-Charron, A., and Wilcox, K.S. (2007) Differential Contribution of Kainate Receptors to Excitatory Postsynaptic Currents in Superficial Layer Neurons of the Rat Medial Entorhinal Cortex. Neuroscience 146(3):1000-12.

Smith, M.D., Adams, A.C., Saunders, G.W., White, H.S., and Wilcox, K.S. (2007) Phenytoin- and Carbamazepine-Resistant Spontaneous Bursting in Rat Entorhinal Cortex Is Blocked by Retigabine In Vitro. Epilepsy Res 74 (2-3):97-106.

Smith, M.D., Wilcox, K.S., and White, H.S.(2007) Discovery of Antiepileptic Drugs. Neurotherapeutics. 4(1):12-7.

Smeal, R. M., Gaspar, R., Keefe, K.A., and Wilcox, K.S (2007) A rat brain slice preparation for characterizing both thalamostriatal and corticostriatal afferents. J Neurosci Methods. 159(2):224-35.

Simeone, T.A., Otto, J.F., Wilcox, K.S., and White, H.S. (2006) Felbamate is a subunit selective modulator of recombinant gamma-aminobutyric acid type A receptors expressed in Xenopus oocytes. Eur J Pharmacol 552:31-35.

Alex A.B., Baucum A.J., and Wilcox, K.S. (2006) Effect of Conantokin G on NMDA receptor-mediated spontaneous EPSCs in cultured cortical neurons. J Neurophysiol 96:1084-1092.

Simeone, T.A., Wilcox, K.S., and White, H.S. (2006) Subunit selectivity of topiramate modulation of heteromeric GABAA receptors. Neuropharmacology 50(7):845-57.

Otto, J.F., Yang, Y., Frankel, W.N., White, H.S. and Wilcox, K.S. (2006) A Spontaneous Mutation Involving Kcnq2 (Kv7.2) Reduces M Current Density and Spike Frequency Adaptation in Mouse CA1 Neurons. J. Neurosci. 26(7): 2053-9.

 

 

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