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Bailey Miller

Bailey Miller

Assistant Research Professor of Medicinal Chemistry




  • B.S. 2009, Biopsychology, University of California Santa Barbara

  • Ph.D. 2016, Marine Chemical Biology, University of California San Diego

Research Interests

COP Schmidt Lab Bailey Miller

Antibiotics discovery from marine shipworm symbionts

Shipworms are wood-eating marine bivalves that host symbiotic bacteria in their gill tissues. These microbes provide the animal enzymes to help digest the lignocellulose from their woody diet and are also prolific producers of complex secondary metabolites. These molecules may play a role in protecting their host from infection by pathogens or in protecting their shared food resources from pathogens. My research focuses on isolating and characterizing these molecules as antibiotics that could be used for human health. Recent advances include the discovery of the turnercyclamycins, a new family of cyclic lipodepsipeptides with in vivo efficacy against Acinetobacter baumannii




  1. Miller, B.W., Schmidt, E.W, Concepcion, G.P., Haygood, M.G. Halogenated metal-binding compounds from shipworm symbionts. Journal of Natural Products2022  
  2. Miller, B.W., Lim, A.L., Lin, Z., Bailey, J., Aoyagi, K.L., Fisher, M.A., Barrows, L.R., Manoil, C., Haygood, M.G., Schmidt, E.W. Shipworm symbiosis ecology-guided discovery of an antibiotic the kills colistin-resistant AcinetobacterCell Chemical Biology2021  
  3. Lacerna, N. M., Ramones, C.M.V., Robes, J.M.D., Picart, M.R.D., Tun, J.O., Miller, B.W., Haygood, M.G., Schmidt, E.W., Salvador-Reyes, L.A., Concepcion, G.P. Inhibition of biofilm formation by modified oxylipins from the shipworm symbiont Teredinibacter turneraeMarine Drugs2020  
  4. Miller, B.W.*, Torres, J.P.*, Tun, J.O.*, Flores, M.S., Forteza, I., Rosenberg, G., Haygood, M.G., Schmidt, E.W., Concepcion, G.P. Synergistic anti-methicillin-resistant Staphylococcus aureus (MRSA) activity and absolute stereochemistry of 7,8-dideoxygriseorhodin C. J. Antibiotics. 2020, 73(5), 290-298 *Indicates co-first authors  
  5. Boudraeu, P.D.*, Miller, B.W.*, McCall, L, Almaliti, J., Reher, R., Hirata, K., Le, T., Siqueira-Neto, J., Hook, V., Gerwick, W.H. Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Porteases Human Cathepsin L and Trypanosoma cruzi Cruzain. Journal of Medicinal Chemistry2019  
  6. Lacerna II, N., Miller, B.W., Lim, A. L., Tun, J.O., Robes, J.M.D., Cleofas, M.J.B., Lin, Z., Salvador-Reyes, L., Haygood, M.G., Schmidt, E.W., Concepcion, G.P. Mindapyrroles A-C, Pyoluteorin Analogs from A Shipworm-Associated Bacterium. Journal of Natural Products2019, 82 (4), 1024-1028
  7. Almaliti, J., Miller, B. W., Pietraszkiewicz, H., Glukhov, E., Naman, C. B., Kline, T., Hanson, J., Li, X., Zhou, S., Valeriote, F. A., et al. Exploration of the Carmaphycins as Payloads in Antibody Drug Conjugate Anticancer Agents. European Journal of Medicinal Chemistry 2019, 161, 416–432.  
  8. Naman, C.B., Rattan, R., Nikoulina, S.E., Lee, J., Miller, B.W., Moss, N.A., Armstrong, L., Boudreau, P.D., Debonsi, H.M., Valeriote, F.A., et al. Integrating Molecular Networking and Biological Assays to Target the Isolation of a Cytotoxic Cyclic Octapeptide, Samoamide A, from an American Samoan Marine Cyanobacterium. J. Nat. Prod. 2017, 80 (3), 625–633.  
  9. Miller, B., Friedman, A.J., Choi, H., Hogan, J., McCammon, J.A., Hook, V., Gerwick, W.H. The Marine Cyanobacterial Metabolite Gallinamide A Is a Potent and Selective Inhibitor of Human Cathepsin L. J. Nat. Prod. 2014, 77 (1), 92–99.