Antibiotics discovery from marine shipworm symbionts
Shipworms are wood-eating marine bivalves that host symbiotic bacteria in their gill tissues. These microbes provide the animal enzymes to help digest the lignocellulose from their woody diet and are also prolific producers of complex secondary metabolites. These molecules may play a role in protecting their host from infection by pathogens or in protecting their shared food resources from pathogens. My research focuses on isolating and characterizing these molecules as antibiotics that could be used for human health. Recent advances include the discovery of the turnercyclamycins, a new family of cyclic lipodepsipeptides with in vivo efficacy against Acinetobacter baumannii.
- Miller, B.W., Schmidt, E.W, Concepcion, G.P., Haygood, M.G. Halogenated metal-binding compounds from shipworm symbionts. Journal of Natural Products. 2022
- Miller, B.W., Lim, A.L., Lin, Z., Bailey, J., Aoyagi, K.L., Fisher, M.A., Barrows, L.R., Manoil, C., Haygood, M.G., Schmidt, E.W. Shipworm symbiosis ecology-guided discovery of an antibiotic the kills colistin-resistant Acinetobacter. Cell Chemical Biology. 2021
- Lacerna, N. M., Ramones, C.M.V., Robes, J.M.D., Picart, M.R.D., Tun, J.O., Miller, B.W., Haygood, M.G., Schmidt, E.W., Salvador-Reyes, L.A., Concepcion, G.P. Inhibition of biofilm formation by modified oxylipins from the shipworm symbiont Teredinibacter turnerae. Marine Drugs. 2020
- Miller, B.W.*, Torres, J.P.*, Tun, J.O.*, Flores, M.S., Forteza, I., Rosenberg, G., Haygood, M.G., Schmidt, E.W., Concepcion, G.P. Synergistic anti-methicillin-resistant Staphylococcus aureus (MRSA) activity and absolute stereochemistry of 7,8-dideoxygriseorhodin C. J. Antibiotics. 2020, 73(5), 290-298 *Indicates co-first authors
- Boudraeu, P.D.*, Miller, B.W.*, McCall, L, Almaliti, J., Reher, R., Hirata, K., Le, T., Siqueira-Neto, J., Hook, V., Gerwick, W.H. Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Porteases Human Cathepsin L and Trypanosoma cruzi Cruzain. Journal of Medicinal Chemistry. 2019
- Lacerna II, N., Miller, B.W., Lim, A. L., Tun, J.O., Robes, J.M.D., Cleofas, M.J.B., Lin, Z., Salvador-Reyes, L., Haygood, M.G., Schmidt, E.W., Concepcion, G.P. Mindapyrroles A-C, Pyoluteorin Analogs from A Shipworm-Associated Bacterium. Journal of Natural Products. 2019, 82 (4), 1024-1028
- Almaliti, J., Miller, B. W., Pietraszkiewicz, H., Glukhov, E., Naman, C. B., Kline, T., Hanson, J., Li, X., Zhou, S., Valeriote, F. A., et al. Exploration of the Carmaphycins as Payloads in Antibody Drug Conjugate Anticancer Agents. European Journal of Medicinal Chemistry 2019, 161, 416–432.
- Naman, C.B., Rattan, R., Nikoulina, S.E., Lee, J., Miller, B.W., Moss, N.A., Armstrong, L., Boudreau, P.D., Debonsi, H.M., Valeriote, F.A., et al. Integrating Molecular Networking and Biological Assays to Target the Isolation of a Cytotoxic Cyclic Octapeptide, Samoamide A, from an American Samoan Marine Cyanobacterium. J. Nat. Prod. 2017, 80 (3), 625–633.
- Miller, B., Friedman, A.J., Choi, H., Hogan, J., McCammon, J.A., Hook, V., Gerwick, W.H. The Marine Cyanobacterial Metabolite Gallinamide A Is a Potent and Selective Inhibitor of Human Cathepsin L. J. Nat. Prod. 2014, 77 (1), 92–99.