Drs. Nitish Khurana, Venkata Yellepeddi, Hamid Ghandehari, and Kevin M. Watt receive Journal of ExtraCorporeal Technology Technique Article Award
Congratulations to Drs. Nitish Khurana (Molecular Pharmaceutics and Pediatrics), Venkata Yellepeddi (Pediatrics), Hamid Ghandehari (Molecular Pharmaceutics), and Kevin M. Watt (Pediatrics)! Their manuscript “Direct and Continuous Dosing of Propofol can Saturate Ex vivo ECMO Circuit to Improve Propofol Recovery” in the Journal of ExtraCorporeal Technology was selected for the JECT Technique Article Award.
Extracorporeal membrane oxygenation (ECMO) is a cardiopulmonary bypass device that provides life-saving complete respiratory and cardiac support in patients with cardiorespiratory failure. The majority of drugs prescribed to patients on ECMO lack a dosing strategy optimized for ECMO patients. Several studies demonstrated that dosing is different in this population because the ECMO circuit components can adsorb drugs and affect drug exposure substantially. Saturation of ECMO circuit components by drug disposition has been posited but has not been proven. In this study, it is demonstrated that following a continuous infusion of propofol, its adsorption is saturable when administered through the circuit. The saturation of the circuit can occur due to the hydrophobic interactions between the hydrophobic drug propofol and the hydrophobic material of the ECMO circuit components. This is the first study to definitively show that adsorption by the ECMO circuit is saturable after an infusion dose is administered.
The JECT Technique Article Award is presented annually to the American Society of Extracorporeal Technology member who has published an exceptional technique article in the Journal of ExtraCorporeal Technology. The JECT Awards will be presented at the AmSECT 62nd International Conference held from March 20-24, 2024 in New Orleans, LA.
